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IID00108
 UniprotQ9Y253
ProteinDNA polymerase eta
GenePOLH
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
713
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-432 Monomer :
 Evidence X-RAY 3mr2 A Reference
       Region 3mr2 A 1-154 order
       Region 3mr2 A 155-157 disorder
       Region 3mr2 A 158-410 order
       Region 3mr2 A 411-412 disorder
       Region 3mr2 A 413-432 order
 Evidence X-RAY 3mr3 A Reference
       Region 3mr3 A 1-132 order
       Region 3mr3 A 133-134 disorder
       Region 3mr3 A 135-153 order
       Region 3mr3 A 154-158 disorder
       Region 3mr3 A 159-432 order
 Evidence X-RAY 3mr5 A Reference
       Region 3mr5 A 1-155 order
       Region 3mr5 A 156-158 disorder
       Region 3mr5 A 159-432 order
 Evidence X-RAY 3mr6 A Reference
       Region 3mr6 A 1-154 order
       Region 3mr6 A 155-160 disorder
       Region 3mr6 A 161-410 order
       Region 3mr6 A 411-412 disorder
       Region 3mr6 A 413-432 order
 Evidence X-RAY 3si8 A Reference
       Region 3si8 A 1-153 order
       Region 3si8 A 154-160 disorder
       Region 3si8 A 161-407 order
       Region 3si8 A 408-410 disorder
       Region 3si8 A 411-430 order
       Region 3si8 A 431-432 disorder
 Evidence X-RAY 3tq1 A Reference
       Region 3tq1 A 1-153 order
       Region 3tq1 A 154-159 disorder
       Region 3tq1 A 160-409 order
       Region 3tq1 A 410-412 disorder
       Region 3tq1 A 413-432 order
 Evidence X-RAY 4dl2 A Reference
       Region 4dl2 A 1-1 disorder
       Region 4dl2 A 2-154 order
       Region 4dl2 A 155-157 disorder
       Region 4dl2 A 158-432 order
 Evidence X-RAY 4dl3 A Reference
       Region 4dl3 A 1-154 order
       Region 4dl3 A 155-159 disorder
       Region 4dl3 A 160-432 order
 Evidence X-RAY 4dl4 A Reference
       Region 4dl4 A 1-154 order
       Region 4dl4 A 155-157 disorder
       Region 4dl4 A 158-432 order
 Evidence X-RAY 4dl5 A Reference
       Region 4dl5 A 1-1 disorder
       Region 4dl5 A 2-153 order
       Region 4dl5 A 154-157 disorder
       Region 4dl5 A 158-409 order
       Region 4dl5 A 410-412 disorder
       Region 4dl5 A 413-432 order
 Evidence X-RAY 4dl6 A Reference
       Region 4dl6 A 1-2 disorder
       Region 4dl6 A 3-154 order
       Region 4dl6 A 155-157 disorder
       Region 4dl6 A 158-409 order
       Region 4dl6 A 410-412 disorder
       Region 4dl6 A 413-432 order
 Evidence X-RAY 4dl7 A Reference
       Region 4dl7 A 1-153 order
       Region 4dl7 A 154-159 disorder
       Region 4dl7 A 160-409 order
       Region 4dl7 A 410-412 disorder
       Region 4dl7 A 413-432 order
 Evidence X-RAY 4ecq A Reference
       Region 4ecq A 1-154 order
       Region 4ecq A 155-159 disorder
       Region 4ecq A 160-432 order
 Evidence X-RAY 4ecr A Reference
       Region 4ecr A 1-154 order
       Region 4ecr A 155-159 disorder
       Region 4ecr A 160-432 order
 Evidence X-RAY 4ecs A Reference
       Region 4ecs A 1-154 order
       Region 4ecs A 155-159 disorder
       Region 4ecs A 160-432 order
 Evidence X-RAY 4ect A Reference
       Region 4ect A 1-154 order
       Region 4ect A 155-159 disorder
       Region 4ect A 160-432 order
 Evidence X-RAY 4ecu A Reference
       Region 4ecu A 1-154 order
       Region 4ecu A 155-159 disorder
       Region 4ecu A 160-432 order
 Evidence X-RAY 4ecv A Reference
       Region 4ecv A 1-154 order
       Region 4ecv A 155-159 disorder
       Region 4ecv A 160-432 order
 Evidence X-RAY 4ecw A Reference
       Region 4ecw A 1-154 order
       Region 4ecw A 155-157 disorder
       Region 4ecw A 158-432 order
 Evidence X-RAY 4ecx A Reference
       Region 4ecx A 1-154 order
       Region 4ecx A 155-159 disorder
       Region 4ecx A 160-432 order
 Evidence X-RAY 4ecy A Reference
       Region 4ecy A 1-154 order
       Region 4ecy A 155-159 disorder
       Region 4ecy A 160-432 order
 Evidence X-RAY 4ecz A Reference
       Region 4ecz A 1-154 order
       Region 4ecz A 155-159 disorder
       Region 4ecz A 160-432 order
 Evidence X-RAY 4ed0 A Reference
       Region 4ed0 A 1-154 order
       Region 4ed0 A 155-159 disorder
       Region 4ed0 A 160-432 order
 Evidence X-RAY 4ed1 A Reference
       Region 4ed1 A 1-154 order
       Region 4ed1 A 155-159 disorder
       Region 4ed1 A 160-432 order
 Evidence X-RAY 4ed2 A Reference
       Region 4ed2 A 1-154 order
       Region 4ed2 A 155-159 disorder
       Region 4ed2 A 160-432 order
 Evidence X-RAY 4ed3 A Reference
       Region 4ed3 A 1-154 order
       Region 4ed3 A 155-159 disorder
       Region 4ed3 A 160-432 order
 Evidence X-RAY 4ed6 A Reference
       Region 4ed6 A 1-154 order
       Region 4ed6 A 155-157 disorder
       Region 4ed6 A 158-432 order
 Evidence X-RAY 4ed7 A Reference
       Region 4ed7 A 1-154 order
       Region 4ed7 A 155-159 disorder
       Region 4ed7 A 160-432 order
 Evidence X-RAY 4ed8 A Reference
       Region 4ed8 A 1-154 order
       Region 4ed8 A 155-159 disorder
       Region 4ed8 A 160-432 order
 Evidence X-RAY 4eey A Reference
       Region 4eey A 1-1 disorder
       Region 4eey A 2-155 order
       Region 4eey A 156-157 disorder
       Region 4eey A 158-409 order
       Region 4eey A 410-412 disorder
       Region 4eey A 413-432 order
 Evidence X-RAY 4j9k A Reference
       Region 4j9k A 1-154 order
       Region 4j9k A 155-159 disorder
       Region 4j9k A 160-432 order
 Evidence X-RAY 4j9l A Reference
       Region 4j9l A 1-154 order
       Region 4j9l A 155-159 disorder
       Region 4j9l A 160-432 order
 Evidence X-RAY 4j9m A Reference
       Region 4j9m A 1-153 order
       Region 4j9m A 154-159 disorder
       Region 4j9m A 160-432 order
 Evidence X-RAY 4j9n A Reference
       Region 4j9n A 1-154 order
       Region 4j9n A 155-159 disorder
       Region 4j9n A 160-432 order
 Evidence X-RAY 4j9o A Reference
       Region 4j9o A 1-2 disorder
       Region 4j9o A 3-154 order
       Region 4j9o A 155-159 disorder
       Region 4j9o A 160-178 order
       Region 4j9o A 179-181 disorder
       Region 4j9o A 182-409 order
       Region 4j9o A 410-413 disorder
       Region 4j9o A 414-432 order
 Evidence X-RAY 4j9p A Reference
       Region 4j9p A 1-1 disorder
       Region 4j9p A 2-154 order
       Region 4j9p A 155-158 disorder
       Region 4j9p A 159-410 order
       Region 4j9p A 411-412 disorder
       Region 4j9p A 413-432 order
 Evidence X-RAY 4j9q A Reference
       Region 4j9q A 1-2 disorder
       Region 4j9q A 3-154 order
       Region 4j9q A 155-157 disorder
       Region 4j9q A 158-432 order
 Evidence X-RAY 4j9r A Reference
       Region 4j9r A 1-2 disorder
       Region 4j9r A 3-153 order
       Region 4j9r A 154-157 disorder
       Region 4j9r A 158-409 order
       Region 4j9r A 410-412 disorder
       Region 4j9r A 413-432 order
 Evidence X-RAY 4j9s A Reference
       Region 4j9s A 1-153 order
       Region 4j9s A 154-159 disorder
       Region 4j9s A 160-409 order
       Region 4j9s A 410-412 disorder
       Region 4j9s A 413-432 order
 Evidence X-RAY 4o3n A Reference
       Region 4o3n A 1-154 order
       Region 4o3n A 155-159 disorder
       Region 4o3n A 160-432 order
 Evidence X-RAY 4o3o A Reference
       Region 4o3o A 1-155 order
       Region 4o3o A 156-159 disorder
       Region 4o3o A 160-432 order
 Evidence X-RAY 4o3p A Reference
       Region 4o3p A 1-155 order
       Region 4o3p A 156-159 disorder
       Region 4o3p A 160-432 order
 Evidence X-RAY 4o3q A Reference
       Region 4o3q A 1-154 order
       Region 4o3q A 155-159 disorder
       Region 4o3q A 160-432 order
 Evidence X-RAY 4o3r A Reference
       Region 4o3r A 1-154 order
       Region 4o3r A 155-159 disorder
       Region 4o3r A 160-432 order
 Evidence X-RAY 4o3s A Reference
       Region 4o3s A 1-154 order
       Region 4o3s A 155-159 disorder
       Region 4o3s A 160-432 order
 Evidence X-RAY 4q8e A Reference
       Region 4q8e A 1-154 order
       Region 4q8e A 155-159 disorder
       Region 4q8e A 160-432 order
 Evidence X-RAY 4q8f A Reference
       Region 4q8f A 1-154 order
       Region 4q8f A 155-159 disorder
       Region 4q8f A 160-326 order
       Region 4q8f A 327-327 disorder
       Region 4q8f A 328-376 order
       Region 4q8f A 377-377 disorder
       Region 4q8f A 378-432 order
 Evidence X-RAY 4rnm A Reference
       Region 4rnm A 1-154 order
       Region 4rnm A 155-159 disorder
       Region 4rnm A 160-432 order
 Evidence X-RAY 4rnn A Reference
       Region 4rnn A 1-154 order
       Region 4rnn A 155-159 disorder
       Region 4rnn A 160-432 order
 Evidence X-RAY 4rno A Reference
       Region 4rno A 1-132 order
       Region 4rno A 133-133 disorder
       Region 4rno A 134-154 order
       Region 4rno A 155-159 disorder
       Region 4rno A 160-416 order
       Region 4rno A 417-417 disorder
       Region 4rno A 418-432 order
 Evidence X-RAY 4ru9 A Reference
       Region 4ru9 A 1-154 order
       Region 4ru9 A 155-159 disorder
       Region 4ru9 A 160-432 order
 Evidence X-RAY 4yp3 A Reference
       Region 4yp3 A 1-152 order
       Region 4yp3 A 153-159 disorder
       Region 4yp3 A 160-374 order
       Region 4yp3 A 375-378 disorder
       Region 4yp3 A 379-432 order
 Evidence X-RAY 4yqw A Reference
       Region 4yqw A 1-154 order
       Region 4yqw A 155-159 disorder
       Region 4yqw A 160-377 order
       Region 4yqw A 378-378 disorder
       Region 4yqw A 379-409 order
       Region 4yqw A 410-412 disorder
       Region 4yqw A 413-432 order
 Evidence X-RAY 4yr0 A Reference
       Region 4yr0 A 1-132 order
       Region 4yr0 A 133-133 disorder
       Region 4yr0 A 134-152 order
       Region 4yr0 A 153-160 disorder
       Region 4yr0 A 161-409 order
       Region 4yr0 A 410-413 disorder
       Region 4yr0 A 414-432 order
 Evidence X-RAY 4yr2 A Reference
       Region 4yr2 A 1-152 order
       Region 4yr2 A 153-159 disorder
       Region 4yr2 A 160-373 order
       Region 4yr2 A 374-377 disorder
       Region 4yr2 A 378-409 order
       Region 4yr2 A 410-412 disorder
       Region 4yr2 A 413-432 order
 Evidence X-RAY 4yr3 A Reference
       Region 4yr3 A 1-152 order
       Region 4yr3 A 153-159 disorder
       Region 4yr3 A 160-373 order
       Region 4yr3 A 374-377 disorder
       Region 4yr3 A 378-411 order
       Region 4yr3 A 412-412 disorder
       Region 4yr3 A 413-432 order
 Evidence X-RAY 5dg7 A Reference
       Region 5dg7 A 1-154 order
       Region 5dg7 A 155-159 disorder
       Region 5dg7 A 160-432 order
 Evidence X-RAY 5dg8 A Reference
       Region 5dg8 A 1-154 order
       Region 5dg8 A 155-159 disorder
       Region 5dg8 A 160-432 order
 Evidence X-RAY 5dg9 A Reference
       Region 5dg9 A 1-154 order
       Region 5dg9 A 155-159 disorder
       Region 5dg9 A 160-432 order
 Evidence X-RAY 5dga A Reference
       Region 5dga A 1-154 order
       Region 5dga A 155-159 disorder
       Region 5dga A 160-432 order
 Evidence X-RAY 5dgb A Reference
       Region 5dgb A 1-154 order
       Region 5dgb A 155-159 disorder
       Region 5dgb A 160-432 order
 Evidence X-RAY 5dlf A Reference
       Region 5dlf A 1-154 order
       Region 5dlf A 155-159 disorder
       Region 5dlf A 160-432 order
 Evidence X-RAY 5dlg A Reference
       Region 5dlg A 1-154 order
       Region 5dlg A 155-159 disorder
       Region 5dlg A 160-432 order
 Evidence X-RAY 5dqg A Reference
       Region 5dqg A 1-154 order
       Region 5dqg A 155-159 disorder
       Region 5dqg A 160-432 order
 Evidence X-RAY 5dqh A Reference
       Region 5dqh A 1-154 order
       Region 5dqh A 155-159 disorder
       Region 5dqh A 160-432 order
 Evidence X-RAY 5dqi A Reference
       Region 5dqi A 1-1 disorder
       Region 5dqi A 2-153 order
       Region 5dqi A 154-160 disorder
       Region 5dqi A 161-432 order
 Evidence X-RAY 5ewe A Reference
       Region 5ewe A 1-152 order
       Region 5ewe A 153-160 disorder
       Region 5ewe A 161-432 order
 Evidence X-RAY 5ewf A Reference
       Region 5ewf A 1-153 order
       Region 5ewf A 154-160 disorder
       Region 5ewf A 161-409 order
       Region 5ewf A 410-412 disorder
       Region 5ewf A 413-432 order
 Evidence X-RAY 5ewg A Reference
       Region 5ewg A 1-152 order
       Region 5ewg A 153-160 disorder
       Region 5ewg A 161-410 order
       Region 5ewg A 411-412 disorder
       Region 5ewg A 413-432 order
 Evidence X-RAY 5f9l A Reference
       Region 5f9l A 1-155 order
       Region 5f9l A 156-159 disorder
       Region 5f9l A 160-432 order
 Evidence X-RAY 5f9n A Reference
       Region 5f9n A 1-154 order
       Region 5f9n A 155-159 disorder
       Region 5f9n A 160-432 order
 Evidence X-RAY 5jum A Reference
       Region 5jum A 1-154 order
       Region 5jum A 155-159 disorder
       Region 5jum A 160-432 order
 Evidence X-RAY 5kfa A Reference
       Region 5kfa A 1-154 order
       Region 5kfa A 155-159 disorder
       Region 5kfa A 160-432 order
 Evidence X-RAY 5kfb A Reference
       Region 5kfb A 1-154 order
       Region 5kfb A 155-159 disorder
       Region 5kfb A 160-432 order
 Evidence X-RAY 5kfc A Reference
       Region 5kfc A 1-154 order
       Region 5kfc A 155-159 disorder
       Region 5kfc A 160-432 order
 Evidence X-RAY 5kfd A Reference
       Region 5kfd A 1-154 order
       Region 5kfd A 155-159 disorder
       Region 5kfd A 160-432 order
 Evidence X-RAY 5kfe A Reference
       Region 5kfe A 1-154 order
       Region 5kfe A 155-159 disorder
       Region 5kfe A 160-432 order
 Evidence X-RAY 5kff A Reference
       Region 5kff A 1-154 order
       Region 5kff A 155-159 disorder
       Region 5kff A 160-432 order
 Evidence X-RAY 5kfg A Reference
       Region 5kfg A 1-154 order
       Region 5kfg A 155-159 disorder
       Region 5kfg A 160-432 order
 Evidence X-RAY 5kfh A Reference
       Region 5kfh A 1-154 order
       Region 5kfh A 155-159 disorder
       Region 5kfh A 160-432 order
 Evidence X-RAY 5kfi A Reference
       Region 5kfi A 1-154 order
       Region 5kfi A 155-159 disorder
       Region 5kfi A 160-432 order
 Evidence X-RAY 5kfj A Reference
       Region 5kfj A 1-154 order
       Region 5kfj A 155-159 disorder
       Region 5kfj A 160-432 order
 Evidence X-RAY 5kfk A Reference
       Region 5kfk A 1-154 order
       Region 5kfk A 155-159 disorder
       Region 5kfk A 160-432 order
 Evidence X-RAY 5kfl A Reference
       Region 5kfl A 1-154 order
       Region 5kfl A 155-159 disorder
       Region 5kfl A 160-432 order
 Evidence X-RAY 5kfm A Reference
       Region 5kfm A 1-132 order
       Region 5kfm A 133-135 disorder
       Region 5kfm A 136-154 order
       Region 5kfm A 155-159 disorder
       Region 5kfm A 160-432 order
 Evidence X-RAY 5kfn A Reference
       Region 5kfn A 1-153 order
       Region 5kfn A 154-160 disorder
       Region 5kfn A 161-432 order
 Evidence X-RAY 5kfo A Reference
       Region 5kfo A 1-153 order
       Region 5kfo A 154-160 disorder
       Region 5kfo A 161-432 order
 Evidence X-RAY 5kfp A Reference
       Region 5kfp A 1-154 order
       Region 5kfp A 155-159 disorder
       Region 5kfp A 160-432 order
 Evidence X-RAY 5kfq A Reference
       Region 5kfq A 1-154 order
       Region 5kfq A 155-159 disorder
       Region 5kfq A 160-432 order
 Evidence X-RAY 5kfr A Reference
       Region 5kfr A 1-154 order
       Region 5kfr A 155-159 disorder
       Region 5kfr A 160-432 order
 Evidence X-RAY 5kfs A Reference
       Region 5kfs A 1-154 order
       Region 5kfs A 155-159 disorder
       Region 5kfs A 160-432 order
 Evidence X-RAY 5kft A Reference
       Region 5kft A 1-154 order
       Region 5kft A 155-159 disorder
       Region 5kft A 160-432 order
 Evidence X-RAY 5kfu A Reference
       Region 5kfu A 1-154 order
       Region 5kfu A 155-159 disorder
       Region 5kfu A 160-432 order
 Evidence X-RAY 5kfv A Reference
       Region 5kfv A 1-154 order
       Region 5kfv A 155-159 disorder
       Region 5kfv A 160-432 order
 Evidence X-RAY 5kfw A Reference
       Region 5kfw A 1-154 order
       Region 5kfw A 155-159 disorder
       Region 5kfw A 160-432 order
 Evidence X-RAY 5kfx A Reference
       Region 5kfx A 1-154 order
       Region 5kfx A 155-159 disorder
       Region 5kfx A 160-432 order
 Evidence X-RAY 5kfy A Reference
       Region 5kfy A 1-154 order
       Region 5kfy A 155-159 disorder
       Region 5kfy A 160-432 order
 Evidence X-RAY 5kfz A Reference
       Region 5kfz A 1-154 order
       Region 5kfz A 155-159 disorder
       Region 5kfz A 160-432 order
 Evidence X-RAY 5kg0 A Reference
       Region 5kg0 A 1-154 order
       Region 5kg0 A 155-159 disorder
       Region 5kg0 A 160-432 order
 Evidence X-RAY 5kg1 A Reference
       Region 5kg1 A 1-154 order
       Region 5kg1 A 155-159 disorder
       Region 5kg1 A 160-432 order
 Evidence X-RAY 5kg2 A Reference
       Region 5kg2 A 1-154 order
       Region 5kg2 A 155-159 disorder
       Region 5kg2 A 160-432 order
 Evidence X-RAY 5kg3 A Reference
       Region 5kg3 A 1-154 order
       Region 5kg3 A 155-159 disorder
       Region 5kg3 A 160-432 order
 Evidence X-RAY 5kg4 A Reference
       Region 5kg4 A 1-154 order
       Region 5kg4 A 155-159 disorder
       Region 5kg4 A 160-432 order
 Evidence X-RAY 5kg5 A Reference
       Region 5kg5 A 1-154 order
       Region 5kg5 A 155-159 disorder
       Region 5kg5 A 160-432 order
 Evidence X-RAY 5kg6 A Reference
       Region 5kg6 A 1-154 order
       Region 5kg6 A 155-158 disorder
       Region 5kg6 A 159-432 order
 Evidence X-RAY 5kg7 A Reference
       Region 5kg7 A 1-154 order
       Region 5kg7 A 155-159 disorder
       Region 5kg7 A 160-432 order
 Evidence X-RAY 5l1i A Reference
       Region 5l1i A 1-154 order
       Region 5l1i A 155-159 disorder
       Region 5l1i A 160-432 order
 Evidence X-RAY 5l1j A Reference
       Region 5l1j A 1-154 order
       Region 5l1j A 155-159 disorder
       Region 5l1j A 160-432 order
 Evidence X-RAY 5l1k A Reference
       Region 5l1k A 1-154 order
       Region 5l1k A 155-159 disorder
       Region 5l1k A 160-432 order
 Evidence X-RAY 5l1l A Reference
       Region 5l1l A 1-154 order
       Region 5l1l A 155-159 disorder
       Region 5l1l A 160-432 order
 Evidence X-RAY 5l9x A Reference
       Region 5l9x A 1-154 order
       Region 5l9x A 155-159 disorder
       Region 5l9x A 160-432 order
Seq 524-539 Hetero dimer : IID00284Complex
 Evidence NMR 2lsk B Reference
       Region 2lsk B 524-539 order
       Region 2lsk B 524-527 high_rmsd
Seq 628-665 Monomer :
 Evidence NMR 2i5o A Reference
       Region 2i5o A 628-628 disorder
       Region 2i5o A 629-662 order
       Region 2i5o A 629-629 high_rmsd
       Region 2i5o A 662-662 high_rmsd
 Evidence X-RAY 3wup A Reference
       Region 3wup A 630-660 order
       Region 3wup A 661-665 disorder
SeqProS possible 524-539 This region is described to adopt alpha-helical conformation only upon binding the Rev1-CT domain (PubMed=22691049). Hetero dimer : IID00284Complex
       Region 2lsk B 524-539 order
 
Prediction
NeProc
Disorder 1-4,147-180,437-442,445-713
Order 5-146,181-432,443-444
ProS 147-177,437-442,479-486,503-507,518-558,565-588,596-599,607-615,628-663,701-713
AlphaFold
Disorder 155-160,434-444,446-479,483-483,491-630,665-713
Order 1-154,161-433,445-445,480-482,484-490,631-664
Pfam Hmmer
PF00817 12-431 1.7e-68
SEG 335-350 ,435-447 ,533-559 ,598-612
Function
Function in SwissProt
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).