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IID00109
 UniprotQ9Y618
ProteinNuclear receptor corepressor 2
GeneNCOR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2525
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 167-207 Hetero dimer : IID00320Complex
 Evidence NMR 2l5g B Reference
       Region 2l5g B 167-207 order
       Region 2l5g B 207-207 high_rmsd
Seq 389-480 Hetero dimer : IID00428Complex
 Evidence X-RAY 4a69 C Reference
       Region 4a69 C 389-407 disorder
       Region 4a69 C 408-476 order
       Region 4a69 C 477-480 disorder
 Evidence X-RAY 4a69 D Reference
       Region 4a69 D 389-407 disorder
       Region 4a69 D 408-475 order
       Region 4a69 D 476-480 disorder
Seq 412-480 Monomer :
 Evidence NMR 1xc5 A Reference
       Region 1xc5 A 412-412 disorder
       Region 1xc5 A 413-480 order
       Region 1xc5 A 413-417 high_rmsd
       Region 1xc5 A 480-480 high_rmsd
Seq 615-685 Monomer :
 Evidence NMR 2ltp A Reference
       Region 2ltp A 615-685 order
       Region 2ltp A 659-660 high_rmsd
       Region 2ltp A 683-685 high_rmsd
Seq 1109-1121 Hetero dimer : IID00381Complex
 Evidence NMR 2odd B Reference
       Region 2odd B 1109-1121 order
Seq 1422-1438 Hetero tetramer : IID00372Complex
 Evidence X-RAY 1r2b D Reference
       Region 1r2b D 1422-1438 order
 Evidence X-RAY 1r2b C Reference
       Region 1r2b C 1422-1438 order
Seq 2346-2361 Hetero octamer : IID00031Complex
 Evidence X-RAY 3r29 D Reference
       Region 3r29 D 2346-2348 disorder
       Region 3r29 D 2349-2359 order
       Region 3r29 D 2360-2361 disorder
 Evidence X-RAY 3r29 C Reference
       Region 3r29 C 2346-2361 order
Seq 2346-2361 Hetero hexamer : IID00031Complex
 Evidence X-RAY 3r2a F Reference
       Region 3r2a F 2346-2354 order
       Region 3r2a F 2355-2361 disorder
 Evidence X-RAY 3r2a E Reference
       Region 3r2a E 2346-2346 disorder
       Region 3r2a E 2347-2353 order
       Region 3r2a E 2354-2361 disorder
Seq 2346-2362 Hetero dimer : P06401
 Evidence X-RAY 4oar B Reference
       Region 4oar B 2346-2348 disorder
       Region 4oar B 2349-2359 order
       Region 4oar B 2360-2362 disorder
Seq 2346-2367 Hetero dimer : G1RH57
 Evidence X-RAY 5x8x B Reference
       Region 5x8x B 2346-2346 disorder
       Region 5x8x B 2347-2359 order
       Region 5x8x B 2360-2367 disorder
 Evidence X-RAY 5x8x D Reference
       Region 5x8x D 2346-2360 order
       Region 5x8x D 2361-2367 disorder
 Evidence X-RAY 5x8x F Reference
       Region 5x8x F 2346-2359 order
       Region 5x8x F 2360-2367 disorder
 Evidence X-RAY 5x8x H Reference
       Region 5x8x H 2346-2360 order
       Region 5x8x H 2361-2367 disorder
Seq 2346-2367 Hetero dimer : IID00305Complex
 Evidence X-RAY 5x8q B Reference
       Region 5x8q B 2346-2360 order
       Region 5x8q B 2361-2367 disorder
 Evidence X-RAY 5x8q D Reference
       Region 5x8q D 2346-2346 disorder
       Region 5x8q D 2347-2360 order
       Region 5x8q D 2361-2367 disorder
 Evidence X-RAY 5x8q F Reference
       Region 5x8q F 2346-2346 disorder
       Region 5x8q F 2347-2360 order
       Region 5x8q F 2361-2367 disorder
 Evidence X-RAY 5x8q H Reference
       Region 5x8q H 2346-2360 order
       Region 5x8q H 2361-2367 disorder
Seq 2346-2367 Hetero nonamer : IID00057Complex
 Evidence X-RAY 2gpv I Reference
       Region 2gpv I 2346-2348 disorder
       Region 2gpv I 2349-2360 order
       Region 2gpv I 2361-2367 disorder
 Evidence X-RAY 2gpv H Reference
       Region 2gpv H 2346-2348 disorder
       Region 2gpv H 2349-2360 order
       Region 2gpv H 2361-2367 disorder
 Evidence X-RAY 2gpv G Reference
       Region 2gpv G 2346-2348 disorder
       Region 2gpv G 2349-2360 order
       Region 2gpv G 2361-2367 disorder
Seq 2347-2365 Hetero dimer : IID00382Complex
 Evidence X-RAY 1kkq E Reference
       Region 1kkq E 2347-2365 order
 Evidence X-RAY 1kkq F Reference
       Region 1kkq F 2347-2365 order
 Evidence X-RAY 1kkq G Reference
       Region 1kkq G 2347-2365 order
 Evidence X-RAY 1kkq H Reference
       Region 1kkq H 2347-2365 order
Seq 2518-2525 Hetero dimer : IID00578Complex
 Evidence NMR 2rt5 B Reference
       Region 2rt5 B 2518-2525 order
SeqProS possible 167-207 This region is described to be disordered in the free state (PubMed=21240272). Hetero dimer : IID00320Complex
       Region 2l5g B 167-207 order
SeqProS possible 1109-1121 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : IID00381Complex
       Region 2odd B 1109-1121 order
SeqProS possible 1422-1438 PubMed=14690607 tells "CD indicates that the unliganded SMRT fragment is unstructures.", but no reference is cited. Hetero tetramer : IID00372Complex
       Region 1r2b C 1422-1438 order
       Region 1r2b D 1422-1438 order
SeqProS possible 2346-2360 Hetero dimer : IID00305Complex
       Region 5x8q B 2346-2360 order
       Region 5x8q D 2347-2360 order
       Region 5x8q F 2347-2360 order
       Region 5x8q H 2346-2360 order
SeqProS possible 2346-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero nonamer : IID00057Complex
       Region 2gpv G 2349-2360 order
       Region 2gpv H 2349-2360 order
       Region 2gpv I 2349-2360 order
SeqProS possible 2346-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : P06401
       Region 4oar B 2349-2359 order
SeqProS possible 2346-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : IID00382Complex
       Region 1kkq E 2347-2365 order
       Region 1kkq F 2347-2365 order
       Region 1kkq G 2347-2365 order
       Region 1kkq H 2347-2365 order
SeqProS possible 2346-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero hexamer : IID00031Complex
       Region 3r2a E 2347-2353 order
       Region 3r2a F 2346-2354 order
SeqProS possible 2346-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero octamer : IID00031Complex
       Region 3r29 C 2346-2361 order
       Region 3r29 D 2349-2359 order
Seqphosphorylation
    54-54 Phosphoserine
    67-67 Phosphoserine
    149-149 Phosphoserine
    152-152 Phosphoserine
    156-156 Phosphothreonine
    215-215 Phosphoserine
    493-493 Phosphoserine
    553-553 Phosphothreonine
    554-554 Phosphoserine
    750-750 Phosphoserine
    753-753 Phosphoserine
    939-939 Phosphoserine
    946-946 Phosphothreonine
    956-956 Phosphoserine
    1173-1173 Phosphoserine
    1251-1251 Phosphoserine
    1323-1323 Phosphoserine
    1383-1383 Phosphothreonine
    1479-1479 Phosphoserine
    1539-1539 Phosphoserine
    1595-1595 Phosphoserine
    1619-1619 Phosphoserine
    1775-1775 Phosphoserine
    1778-1778 Phosphoserine
    1861-1861 Phosphoserine
    2005-2005 Phosphoserine
    2046-2046 Phosphoserine
    2054-2054 Phosphoserine
    2057-2057 Phosphoserine
    2058-2058 Phosphoserine
    2060-2060 Phosphoserine
    2062-2062 Phosphothreonine
    2077-2077 Phosphoserine
    2203-2203 Phosphoserine
    2223-2223 Phosphoserine
    2258-2258 Phosphoserine
    2413-2413 Phosphoserine
Seqacetylation
    878-878 N6-acetyllysine
    959-959 N6-acetyllysine
    1210-1210 N6-acetyllysine
    1240-1240 N6-acetyllysine
    1959-1959 N6-acetyllysine
    2026-2026 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-168,207-222,320-383,484-513,549-623,687-2514
Order 169-206,223-319,384-483,514-548,624-686
ProS 12-19,23-29,38-41,47-53,62-75,107-112,140-147,158-161,329-339,347-383,491-494,549-550,573-590,612-617,719-724,1029-1032,1058-1064,1151-1154,1238-1243,1277-1280,1310-1313,1541-1544,1609-1613,1683-1690,1756-1759,2079-2082,2140-2146,2217-2221,2444-2449,2458-2464,2493-2514
AlphaFold
Disorder 1-169,204-224,245-257,347-369,393-415,426-430,487-613,680-2130,2132-2134,2137-2137,2140-2343,2345-2514
Order 170-203,225-244,258-346,370-392,416-425,431-486,614-679,2131-2131,2135-2136,2138-2139,2344-2344
Pfam Hmmer
PF00249 429-474 3.6e-11
PF00249 612-657 2.5e-15
SEG 107-124 ,147-154 ,187-222 ,494-510 ,518-553 ,672-695 ,714-723 ,769-842 ,868-899 ,936-948 ,989-1002 ,1015-1030 ,1079-1089 ,1384-1389 ,1513-1526 ,1737-1754 ,1765-1782 ,1795-1811 ,1834-1846 ,1848-1862 ,1936-1950 ,2000-2019 ,2043-2060 ,2103-2117 ,2149-2164 ,2474-2494
Function
Function in SwissProt
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).