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IID00112
 UniprotO95405
ProteinZinc finger FYVE domain-containing protein 9
GeneZFYVE9
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1425
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-22 Hetero trimer : Q9H3S7
 Evidence X-RAY 5mjy E Reference
       Region 5mjy E 1-1 disorder
       Region 5mjy E 2-21 order
       Region 5mjy E 22-22 disorder
 Evidence X-RAY 5mjy F Reference
       Region 5mjy F 1-1 disorder
       Region 5mjy F 2-21 order
       Region 5mjy F 22-22 disorder
Seqdisorder 765-853
 Evidence NMR Reference
       Region 765-853 disorder
Seq 771-811 Hetero dimer : IID00127Complex
 Evidence X-RAY 1dev D Reference
       Region 1dev D 771-809 order
       Region 1dev D 810-811 disorder
 Evidence X-RAY 1dev B Reference
       Region 1dev B 771-811 order
Seq 773-810 Hetero tetramer : IID00113Complex
 Evidence X-RAY 1mk2 B Reference
       Region 1mk2 B 773-810 order
Seq 895-1425 Monomer :
 Evidence X-RAY 4bkw A Reference
       Region 4bkw A 895-911 order
       Region 4bkw A 912-916 disorder
       Region 4bkw A 917-934 order
       Region 4bkw A 935-936 disorder
       Region 4bkw A 937-1209 order
       Region 4bkw A 1210-1216 disorder
       Region 4bkw A 1217-1250 order
       Region 4bkw A 1251-1261 disorder
       Region 4bkw A 1262-1298 order
       Region 4bkw A 1299-1300 disorder
       Region 4bkw A 1301-1318 order
       Region 4bkw A 1319-1332 disorder
       Region 4bkw A 1333-1401 order
       Region 4bkw A 1402-1411 disorder
       Region 4bkw A 1412-1424 order
       Region 4bkw A 1425-1425 disorder
SeqProS verified 771-811 Hetero dimer : IID00127Complex
       Region 1dev B 771-811 order
       Region 1dev D 771-809 order
       Region 765-853 disorder
SeqProS verified 771-811 Hetero tetramer : IID00113Complex
       Region 1mk2 B 773-810 order
       Region 765-853 disorder
Seqphosphorylation
    306-306 Phosphoserine
    668-668 Phosphoserine
 
Prediction
NeProc
Disorder 41-689,765-901
Order 1-40,690-764,902-1425
ProS 48-56,63-73,85-97,103-128,133-172,178-184,189-253,259-268,285-296,302-306,341-347,354-363,388-405,422-426,447-454,459-464,475-491,500-522,542-548,575-589,600-606,640-652,689-689,765-791,810-815,825-850,858-862,882-901
AlphaFold
Disorder 1-687,766-893,912-916,1257-1260,1274-1276,1298-1299,1318-1331,1405-1410,1425-1425
Order 688-765,894-911,917-1256,1261-1273,1277-1297,1300-1317,1332-1404,1411-1424
Pfam Hmmer
PF01363 694-759 1.3e-25
SEG 498-514 ,731-740 ,765-780
Function
Function in SwissProt
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Biological Process
Diagram with PDB data
ZFYVE9/SMAD2CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA
ZFYVE9/SMAD3SMAD3 SBD complex