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IID00117
 UniprotQ9Y5B0
ProteinRNA polymerase II subunit A C-terminal domain phosphatase
GeneCTDP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
961
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 582-600 Hetero dimer : IID00369Complex
 Evidence NMR 2k7l B Reference
       Region 2k7l B 582-600 order
       Region 2k7l B 582-582 high_rmsd
Seqdisorder 879-961
 Evidence NMR Reference
       Region 879-961 disorder
Seq 879-961 Hetero dimer : IID00369Complex
 Evidence X-RAY 1j2x B Reference
       Region 1j2x B 944-961 order
 Evidence NMR 1onv B Reference
       Region 1onv B 879-940 disorder
       Region 1onv B 941-961 order
       Region 1onv B 941-942 high_rmsd
SeqProS possible 582-600 LXXLL-like motif Hetero dimer : IID00369Complex
       Region 2k7l B 582-600 order
SeqProS verified 941-961 LXXLL-like motif Hetero dimer : IID00369Complex
       Region 1onv B 941-961 order
       Region 1j2x B 944-961 order
       Region 879-961 disorder
Seqphosphorylation
    395-395 Phosphoserine
    674-674 Phosphoserine
    740-740 Phosphoserine
    839-839 Phosphoserine
    872-872 Phosphoserine
    869-869 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    780-780 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-18,63-71,334-580,739-961
Order 19-62,72-333,581-738
ProS 63-71,346-349,357-363,392-409,435-469,476-487,557-562,571-580,739-762,769-784,808-818,844-867,890-895,914-920,946-961
AlphaFold
Disorder 1-18,56-78,134-145,201-206,334-583,731-771,776-781,784-850,866-943,945-945,960-961
Order 19-55,79-133,146-200,207-333,584-730,772-775,782-783,851-865,944-944,946-959
Pfam Hmmer
PF03031 174-350 2.5e-93
PF00533 629-715 0.00098
SEG 54-72 ,455-480 ,577-588 ,875-891 ,924-948
Function
Function in SwissProt
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.