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IID00124
 UniprotQ13625
ProteinApoptosis-stimulating of p53 protein 2
GeneTP53BP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1128
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-83 Monomer :
 Evidence NMR 2uwq A Reference
       Region 2uwq A 1-83 order
       Region 2uwq A 1-1 high_rmsd
Seq 726-782 Hetero dimer : P55980
 Evidence X-RAY 4irv H Reference
       Region 4irv H 726-745 disorder
       Region 4irv H 746-765 order
       Region 4irv H 766-782 disorder
 Evidence X-RAY 4irv G Reference
       Region 4irv G 726-745 disorder
       Region 4irv G 746-765 order
       Region 4irv G 766-782 disorder
 Evidence X-RAY 4irv F Reference
       Region 4irv F 726-745 disorder
       Region 4irv F 746-765 order
       Region 4irv F 766-782 disorder
 Evidence X-RAY 4irv E Reference
       Region 4irv E 726-745 disorder
       Region 4irv E 746-765 order
       Region 4irv E 766-782 disorder
Seq 892-1126 Hetero dimer : IID00015Complex
 Evidence X-RAY 1ycs B Reference
       Region 1ycs B 892-925 disorder
       Region 1ycs B 926-1118 order
       Region 1ycs B 1119-1126 disorder
Seq 892-1128 Hetero dodecamer : O15350
 Evidence X-RAY 4a63 L Reference
       Region 4a63 L 892-924 disorder
       Region 4a63 L 925-1120 order
       Region 4a63 L 1121-1128 disorder
 Evidence X-RAY 4a63 J Reference
       Region 4a63 J 892-922 disorder
       Region 4a63 J 923-1122 order
       Region 4a63 J 1123-1128 disorder
 Evidence X-RAY 4a63 H Reference
       Region 4a63 H 892-922 disorder
       Region 4a63 H 923-1120 order
       Region 4a63 H 1121-1128 disorder
 Evidence X-RAY 4a63 F Reference
       Region 4a63 F 892-924 disorder
       Region 4a63 F 925-1121 order
       Region 4a63 F 1122-1128 disorder
 Evidence X-RAY 4a63 D Reference
       Region 4a63 D 892-924 disorder
       Region 4a63 D 925-1120 order
       Region 4a63 D 1121-1128 disorder
 Evidence X-RAY 4a63 B Reference
       Region 4a63 B 892-919 disorder
       Region 4a63 B 920-1121 order
       Region 4a63 B 1122-1128 disorder
Seqphosphorylation
    737-737 Phosphoserine
    714-714 Phosphoserine
    698-698 Phosphoserine
    576-576 Phosphoserine
    572-572 Phosphoserine
    569-569 Phosphoserine
    556-556 Phosphoserine
    480-480 Phosphoserine
 
Prediction
NeProc
Disorder 90-121,249-259,326-916,1123-1128
Order 1-89,122-248,260-325,917-1122
ProS 90-93,101-107,112-121,249-253,326-327,341-345,356-376,386-391,440-446,459-464,581-587,606-613,716-720,728-732,894-916,1123-1128
AlphaFold
Disorder 1-3,85-126,248-258,322-714,726-753,756-756,759-920,1091-1092,1124-1128
Order 4-84,127-247,259-321,715-725,754-755,757-758,921-1090,1093-1123
Pfam Hmmer
PF00023 958-990 1.4e-09
PF00023 991-1023 2.7e-09
PF00018 1060-1117 9.2e-14
SEG 138-147 ,154-177 ,490-507 ,769-786 ,840-856 ,864-884
Function
Function in SwissProt
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.