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IID00128
 UniprotQ8WTS6
ProteinHistone-lysine N-methyltransferase SETD7
GeneSETD7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
366
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-366 Monomer :
 Evidence X-RAY 3vv0 A Reference
       Region 3vv0 A 111-115 disorder
       Region 3vv0 A 116-337 order
       Region 3vv0 A 338-349 disorder
       Region 3vv0 A 350-362 order
       Region 3vv0 A 363-366 disorder
 Evidence X-RAY 3vuz A Reference
       Region 3vuz A 111-115 disorder
       Region 3vuz A 116-339 order
       Region 3vuz A 340-347 disorder
       Region 3vuz A 348-362 order
       Region 3vuz A 363-366 disorder
 Evidence X-RAY 1n6c A Reference
       Region 1n6c A 70-78 disorder
       Region 1n6c A 79-337 order
       Region 1n6c A 338-339 disorder
       Region 1n6c A 340-363 order
       Region 1n6c A 364-366 disorder
 Evidence X-RAY 1n6a A Reference
       Region 1n6a A 108-115 disorder
       Region 1n6a A 116-337 order
       Region 1n6a A 338-349 disorder
       Region 1n6a A 350-361 order
       Region 1n6a A 362-366 disorder
 Evidence X-RAY 1muf A Reference
       Region 1muf A 81-337 order
 Evidence X-RAY 1mt6 A Reference
       Region 1mt6 A 58-337 order
 Evidence X-RAY 1h3i B Reference
       Region 1h3i B 52-344 order
 Evidence X-RAY 1h3i A Reference
       Region 1h3i A 52-344 order
 Evidence X-RAY 4e47 D Reference
       Region 4e47 D 109-115 disorder
       Region 4e47 D 116-341 order
       Region 4e47 D 342-345 disorder
       Region 4e47 D 346-366 order
 Evidence X-RAY 4e47 C Reference
       Region 4e47 C 109-116 disorder
       Region 4e47 C 117-340 order
       Region 4e47 C 341-348 disorder
       Region 4e47 C 349-366 order
 Evidence X-RAY 4e47 B Reference
       Region 4e47 B 109-115 disorder
       Region 4e47 B 116-338 order
       Region 4e47 B 339-347 disorder
       Region 4e47 B 348-366 order
 Evidence X-RAY 4e47 A Reference
       Region 4e47 A 109-115 disorder
       Region 4e47 A 116-338 order
       Region 4e47 A 339-345 disorder
       Region 4e47 A 346-366 order
 Evidence X-RAY 5ayf A Reference
       Region 5ayf A 111-115 disorder
       Region 5ayf A 116-366 order
Seq 108-366 Hetero dimer : IID00062Complex
 Evidence X-RAY 1o9s B Reference
       Region 1o9s B 108-116 disorder
       Region 1o9s B 117-366 order
 Evidence X-RAY 1o9s A Reference
       Region 1o9s A 108-116 disorder
       Region 1o9s A 117-366 order
Seq 108-366 Hetero dimer : IID00015Complex
 Evidence X-RAY 1xqh E Reference
       Region 1xqh E 108-116 disorder
       Region 1xqh E 117-366 order
 Evidence X-RAY 1xqh A Reference
       Region 1xqh A 108-116 disorder
       Region 1xqh A 117-366 order
Seq 109-366 Homo dimer :
 Evidence X-RAY 4jlg B Reference
       Region 4jlg B 109-117 disorder
       Region 4jlg B 118-363 order
       Region 4jlg B 364-366 disorder
 Evidence X-RAY 4jlg A Reference
       Region 4jlg A 109-116 disorder
       Region 4jlg A 117-363 order
       Region 4jlg A 364-366 disorder
Seq 109-366 Homo tetramer :
 Evidence X-RAY 4jds D Reference
       Region 4jds D 109-115 disorder
       Region 4jds D 116-259 order
       Region 4jds D 260-260 disorder
       Region 4jds D 261-338 order
       Region 4jds D 339-347 disorder
       Region 4jds D 348-366 order
 Evidence X-RAY 4jds C Reference
       Region 4jds C 109-116 disorder
       Region 4jds C 117-338 order
       Region 4jds C 339-347 disorder
       Region 4jds C 348-366 order
 Evidence X-RAY 4jds B Reference
       Region 4jds B 109-116 disorder
       Region 4jds B 117-338 order
       Region 4jds B 339-347 disorder
       Region 4jds B 348-366 order
 Evidence X-RAY 4jds A Reference
       Region 4jds A 109-115 disorder
       Region 4jds A 116-338 order
       Region 4jds A 339-347 disorder
       Region 4jds A 348-366 order
Seq 110-366 Hetero dimer : IID00465Complex
 Evidence X-RAY 3m5a A Reference
       Region 3m5a A 110-114 disorder
       Region 3m5a A 115-341 order
       Region 3m5a A 342-345 disorder
       Region 3m5a A 346-364 order
       Region 3m5a A 365-366 disorder
 Evidence X-RAY 3m59 A Reference
       Region 3m59 A 110-115 disorder
       Region 3m59 A 116-341 order
       Region 3m59 A 342-345 disorder
       Region 3m59 A 346-364 order
       Region 3m59 A 365-366 disorder
 Evidence X-RAY 3m58 A Reference
       Region 3m58 A 110-341 order
       Region 3m58 A 342-345 disorder
       Region 3m58 A 346-365 order
       Region 3m58 A 366-366 disorder
 Evidence X-RAY 3m57 A Reference
       Region 3m57 A 110-115 disorder
       Region 3m57 A 116-341 order
       Region 3m57 A 342-346 disorder
       Region 3m57 A 347-364 order
       Region 3m57 A 365-366 disorder
 Evidence X-RAY 3m56 A Reference
       Region 3m56 A 110-115 disorder
       Region 3m56 A 116-341 order
       Region 3m56 A 342-346 disorder
       Region 3m56 A 347-364 order
       Region 3m56 A 365-366 disorder
 Evidence X-RAY 3m55 A Reference
       Region 3m55 A 110-115 disorder
       Region 3m55 A 116-341 order
       Region 3m55 A 342-346 disorder
       Region 3m55 A 347-364 order
       Region 3m55 A 365-366 disorder
 Evidence X-RAY 3m54 A Reference
       Region 3m54 A 110-115 disorder
       Region 3m54 A 116-341 order
       Region 3m54 A 342-346 disorder
       Region 3m54 A 347-365 order
       Region 3m54 A 366-366 disorder
 Evidence X-RAY 3m53 A Reference
       Region 3m53 A 110-115 disorder
       Region 3m53 A 116-341 order
       Region 3m53 A 342-345 disorder
       Region 3m53 A 346-365 order
       Region 3m53 A 366-366 disorder
 Evidence X-RAY 4j8o A Reference
       Region 4j8o A 110-115 disorder
       Region 4j8o A 116-341 order
       Region 4j8o A 342-345 disorder
       Region 4j8o A 346-364 order
       Region 4j8o A 365-366 disorder
 Evidence X-RAY 4j83 A Reference
       Region 4j83 A 110-116 disorder
       Region 4j83 A 117-341 order
       Region 4j83 A 342-346 disorder
       Region 4j83 A 347-363 order
       Region 4j83 A 364-366 disorder
 Evidence X-RAY 4j7i A Reference
       Region 4j7i A 110-116 disorder
       Region 4j7i A 117-197 order
       Region 4j7i A 198-198 disorder
       Region 4j7i A 199-341 order
       Region 4j7i A 342-346 disorder
       Region 4j7i A 347-365 order
       Region 4j7i A 366-366 disorder
 Evidence X-RAY 4j7f A Reference
       Region 4j7f A 110-116 disorder
       Region 4j7f A 117-341 order
       Region 4j7f A 342-346 disorder
       Region 4j7f A 347-362 order
       Region 4j7f A 363-366 disorder
 Evidence X-RAY 2f69 A Reference
       Region 2f69 A 110-115 disorder
       Region 2f69 A 116-341 order
       Region 2f69 A 342-346 disorder
       Region 2f69 A 347-364 order
       Region 2f69 A 365-366 disorder
 Evidence X-RAY 5eg2 A Reference
       Region 5eg2 A 110-116 disorder
       Region 5eg2 A 117-341 order
       Region 5eg2 A 342-346 disorder
       Region 5eg2 A 347-364 order
       Region 5eg2 A 365-366 disorder
Seq 111-366 Hetero dimer : IID00013Complex
 Evidence X-RAY 3cbp A Reference
       Region 3cbp A 111-116 disorder
       Region 3cbp A 117-339 order
       Region 3cbp A 340-347 disorder
       Region 3cbp A 348-363 order
       Region 3cbp A 364-366 disorder
 Evidence X-RAY 3cbo A Reference
       Region 3cbo A 111-115 disorder
       Region 3cbo A 116-337 order
       Region 3cbo A 338-347 disorder
       Region 3cbo A 348-364 order
       Region 3cbo A 365-366 disorder
 Evidence X-RAY 3cbm A Reference
       Region 3cbm A 111-115 disorder
       Region 3cbm A 116-341 order
       Region 3cbm A 342-347 disorder
       Region 3cbm A 348-364 order
       Region 3cbm A 365-366 disorder
Seq 111-366 Hetero dimer :
 Evidence X-RAY 3os5 A Reference
       Region 3os5 A 111-115 disorder
       Region 3os5 A 116-364 order
       Region 3os5 A 365-366 disorder
 
Prediction
NeProc
Disorder 1-6,359-366
Order 7-358
ProS 359-363
AlphaFold
Disorder 1-9,345-346,366-366
Order 10-344,347-365
Pfam Hmmer
PF02493 36-58 0.00021
PF00856 212-343 2.4e-16
Function
Function in SwissProt
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Biological Process
See also
Diagram with PDB data
ESR1/SETD7SET7/9-ER-AdoHcy complex
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH