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IID00138
 UniprotP08621
ProteinU1 small nuclear ribonucleoprotein 70 kDa
GeneSNRNP70
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-216 Hetero nonamer : IID00143Complex,IID00161Complex
 Evidence X-RAY 3cw1 8 Reference
       Region 3cw1 8 1-8 disorder
       Region 3cw1 8 9-23 order
       Region 3cw1 8 24-62 disorder
       Region 3cw1 8 63-89 order
       Region 3cw1 8 90-102 disorder
       Region 3cw1 8 103-180 order
       Region 3cw1 8 181-216 disorder
 Evidence X-RAY 3cw1 6 Reference
       Region 3cw1 6 1-8 disorder
       Region 3cw1 6 9-23 order
       Region 3cw1 6 24-62 disorder
       Region 3cw1 6 63-89 order
       Region 3cw1 6 90-102 disorder
       Region 3cw1 6 103-180 order
       Region 3cw1 6 181-216 disorder
 Evidence X-RAY 3cw1 K Reference
       Region 3cw1 K 1-8 disorder
       Region 3cw1 K 9-23 order
       Region 3cw1 K 24-62 disorder
       Region 3cw1 K 63-89 order
       Region 3cw1 K 90-102 disorder
       Region 3cw1 K 103-180 order
       Region 3cw1 K 181-216 disorder
Seq 1-216 Hetero nonamer : IID00139Complex,IID00143Complex,IID00161Complex
 Evidence X-RAY 3cw1 7 Reference
       Region 3cw1 7 1-8 disorder
       Region 3cw1 7 9-23 order
       Region 3cw1 7 24-62 disorder
       Region 3cw1 7 63-89 order
       Region 3cw1 7 90-102 disorder
       Region 3cw1 7 103-180 order
       Region 3cw1 7 181-216 disorder
Seq 1-437 Hetero nonamer : IID00157Complex,IID00159Complex,IID00160Complex
 Evidence X-RAY 3pgw L Reference
       Region 3pgw L 1-33 disorder
       Region 3pgw L 34-181 order
       Region 3pgw L 182-437 disorder
 Evidence X-RAY 3pgw S Reference
       Region 3pgw S 1-33 disorder
       Region 3pgw S 34-183 order
       Region 3pgw S 184-437 disorder
Seq 2-60 Hetero 36mer : IID00139Complex,IID00143Complex,IID00156Complex,IID00157Complex,IID00158Complex,IID00159Complex,IID00160Complex,IID00161Complex
 Evidence X-RAY 4pjo K Reference
       Region 4pjo K 2-59 order
       Region 4pjo K 60-60 disorder
 Evidence X-RAY 4pjo N Reference
       Region 4pjo N 2-5 disorder
       Region 4pjo N 6-58 order
       Region 4pjo N 59-60 disorder
 Evidence X-RAY 4pjo k Reference
       Region 4pjo k 2-2 disorder
       Region 4pjo k 3-59 order
 Evidence X-RAY 4pjo n Reference
       Region 4pjo n 2-59 order
       Region 4pjo n 60-60 disorder
Seq 60-215 Monomer : Q06AA4
 Evidence X-RAY 4pkd B Reference
       Region 4pkd B 60-60 disorder
       Region 4pkd B 61-202 order
       Region 4pkd B 203-215 disorder
Seq 131-151 Monomer :
 Evidence NMR 2l5j A Reference
       Region 2l5j A 131-151 order
 Evidence NMR 2l5i A Reference
       Region 2l5i A 131-151 order
Seqphosphorylation
    226-226 Phosphoserine
    126-126 Phosphotyrosine
    268-268 Phosphoserine
    320-320 Phosphoserine
    410-410 Phosphoserine
Seqacetylation
    2-2 N-acetylthreonine
    118-118 N6-acetyllysine
 
Prediction
NeProc
Disorder 65-73,190-281,310-437
Order 1-64,74-189,282-309
ProS 65-73,190-223,230-235,272-281,335-341,395-433
AlphaFold
Disorder 1-1,203-294,296-296,307-359,381-437
Order 2-202,295-295,297-306,360-380
Pfam Hmmer
PF00076 105-176 1.8e-23
SEG 4-15 ,59-83 ,186-203 ,231-308 ,317-407
Function
Function in SwissProt
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
Isoform 3
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Isoform 4
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.