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IID00139
 UniprotP09234
ProteinU1 small nuclear ribonucleoprotein C
GeneSNRPC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
159
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-61 Hetero 36mer : IID00138Complex,IID00158Complex,IID00161Complex
 Evidence X-RAY 4pjo L Reference
       Region 4pjo L 1-1 disorder
       Region 4pjo L 2-54 order
       Region 4pjo L 55-61 disorder
 Evidence X-RAY 4pjo M Reference
       Region 4pjo M 1-1 disorder
       Region 4pjo M 2-54 order
       Region 4pjo M 55-61 disorder
 Evidence X-RAY 4pjo m Reference
       Region 4pjo m 2-51 order
       Region 4pjo m 52-61 disorder
Seq 1-61 Monomer :
 Evidence NMR 2vrd A Reference
       Region 2vrd A 1-61 order
       Region 2vrd A 1-1 high_rmsd
       Region 2vrd A 58-61 high_rmsd
Seq 1-77 Hetero nonamer : IID00138Complex,IID00158Complex,IID00161Complex
 Evidence X-RAY 3cw1 0 Reference
       Region 3cw1 0 1-3 disorder
       Region 3cw1 0 4-57 order
       Region 3cw1 0 58-77 disorder
Seq 1-77 Hetero nonamer : IID00158Complex,IID00161Complex
 Evidence X-RAY 3cw1 l Reference
       Region 3cw1 l 4-61 order
       Region 3cw1 l 62-77 disorder
 Evidence X-RAY 3cw1 9 Reference
       Region 3cw1 9 1-3 disorder
       Region 3cw1 9 4-61 order
       Region 3cw1 9 62-77 disorder
 Evidence X-RAY 3cw1 L Reference
       Region 3cw1 L 4-60 order
       Region 3cw1 L 61-77 disorder
Seqphosphorylation
    17-17 Phosphoserine
    8-8 Phosphotyrosine
Seqacetylation
    52-52 N6-acetyllysine
 
Prediction
NeProc
Disorder 55-159
Order 1-54
ProS 64-68,154-159
AlphaFold
Disorder 1-1,60-80,84-138,140-159
Order 2-59,81-83,139-139
Pfam Hmmer
PF06220 1-38 2.4e-26
SEG 63-152
Function
Function in SwissProt
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.