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IID00140
 UniprotP11831
ProteinSerum response factor
GeneSRF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
508
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 132-223 Homo dimer :
 Evidence X-RAY 1srs B Reference
       Region 1srs B 132-139 disorder
       Region 1srs B 140-219 order
       Region 1srs B 220-223 disorder
 Evidence X-RAY 1srs A Reference
       Region 1srs A 132-139 disorder
       Region 1srs A 140-223 order
Seq 132-223 Hetero trimer : IID00148Complex
 Evidence X-RAY 1hbx E Reference
       Region 1hbx E 132-134 disorder
       Region 1hbx E 135-223 order
 Evidence X-RAY 1hbx D Reference
       Region 1hbx D 132-137 disorder
       Region 1hbx D 138-223 order
 Evidence X-RAY 1hbx B Reference
       Region 1hbx B 132-137 disorder
       Region 1hbx B 138-223 order
 Evidence X-RAY 1hbx A Reference
       Region 1hbx A 132-136 disorder
       Region 1hbx A 137-223 order
Seq 133-235 Hetero trimer : IID00148Complex
 Evidence X-RAY 1k6o C Reference
       Region 1k6o C 133-137 disorder
       Region 1k6o C 138-221 order
       Region 1k6o C 222-235 disorder
 Evidence X-RAY 1k6o B Reference
       Region 1k6o B 133-136 disorder
       Region 1k6o B 137-221 order
       Region 1k6o B 222-235 disorder
Seqphosphorylation
    77-77 Phosphoserine
    79-79 Phosphoserine
    83-83 Phosphoserine
    103-103 Phosphoserine
    85-85 Phosphoserine
    224-224 Phosphoserine
    253-253 Phosphoserine
    435-435 Phosphoserine; by dsDNA kinase
    446-446 Phosphoserine; by dsDNA kinase
 
Prediction
NeProc
Disorder 1-142,215-508
Order 143-214
ProS 21-29,65-69,87-98,215-223,231-252,259-268,490-502
AlphaFold
Disorder 1-134,227-508
Order 135-226
Pfam Hmmer
PF00319 149-199 2.7e-27
SEG 6-22 ,24-46 ,52-75 ,77-94 ,221-233 ,304-318 ,350-369 ,372-387
Function
Function in SwissProt
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.