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IID00141
 UniprotP14635
ProteinG2/mitotic-specific cyclin-B1
GeneCCNB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
433
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 165-433 Monomer :
 Evidence X-RAY 2b9r B Reference
       Region 2b9r B 165-170 disorder
       Region 2b9r B 171-425 order
       Region 2b9r B 426-433 disorder
 Evidence X-RAY 2b9r A Reference
       Region 2b9r A 165-170 disorder
       Region 2b9r A 171-424 order
       Region 2b9r A 425-433 disorder
Seq 165-433 Hetero hexamer : P06493,P33552
 Evidence X-RAY 5lqf E Reference
       Region 5lqf E 165-166 disorder
       Region 5lqf E 167-430 order
       Region 5lqf E 431-433 disorder
 Evidence X-RAY 5lqf B Reference
       Region 5lqf B 165-166 disorder
       Region 5lqf B 167-430 order
       Region 5lqf B 431-433 disorder
Seq 165-433 Hetero trimer : P06493
 Evidence X-RAY 4y72 B Reference
       Region 4y72 B 165-166 disorder
       Region 4y72 B 167-430 order
       Region 4y72 B 431-433 disorder
 Evidence X-RAY 4yc3 B Reference
       Region 4yc3 B 165-166 disorder
       Region 4yc3 B 167-431 order
       Region 4yc3 B 432-433 disorder
 Evidence X-RAY 5hq0 B Reference
       Region 5hq0 B 165-166 disorder
       Region 5hq0 B 167-430 order
       Region 5hq0 B 431-433 disorder
Seq 167-426 Hetero dimer : IID00034Complex
 Evidence X-RAY 2jgz B Reference
       Region 2jgz B 167-426 order
Seqphosphorylation
    126-126 Phosphoserine; by CDK1
    128-128 Phosphoserine
    133-133 Phosphoserine; by PLK1
    321-321 Phosphothreonine
    147-147 Phosphoserine
Seqacetylation
    73-73 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-149,430-433
Order 150-429
ProS 1-13,39-54,140-149,430-433
AlphaFold
Disorder 1-152,431-433
Order 153-430
Pfam Hmmer
PF00134 173-298 4.9e-67
PF02984 300-422 3.5e-51
SEG 86-119
Function
Function in SwissProt
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Biological Process
See also
Diagram with PDB data
UHRF1/USP7Crystal structure of USP7 in complex with UHRF1