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IID00143
 UniprotP14678
ProteinSmall nuclear ribonucleoprotein-associated proteins B and B'
GeneSNRPB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
240
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-91 Hetero dimer : IID00161Complex
 Evidence X-RAY 1d3b L Reference
       Region 1d3b L 1-1 disorder
       Region 1d3b L 2-91 order
 Evidence X-RAY 1d3b J Reference
       Region 1d3b J 1-1 disorder
       Region 1d3b J 2-87 order
       Region 1d3b J 88-91 disorder
 Evidence X-RAY 1d3b H Reference
       Region 1d3b H 1-2 disorder
       Region 1d3b H 3-88 order
       Region 1d3b H 89-91 disorder
 Evidence X-RAY 1d3b F Reference
       Region 1d3b F 1-4 disorder
       Region 1d3b F 5-87 order
       Region 1d3b F 88-91 disorder
 Evidence X-RAY 1d3b D Reference
       Region 1d3b D 1-1 disorder
       Region 1d3b D 2-87 order
       Region 1d3b D 88-91 disorder
 Evidence X-RAY 1d3b B Reference
       Region 1d3b B 1-6 disorder
       Region 1d3b B 7-87 order
       Region 1d3b B 88-91 disorder
Seq 1-95 Hetero 36mer : IID00138Complex,IID00157Complex,IID00158Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 4pjo B Reference
       Region 4pjo B 1-5 disorder
       Region 4pjo B 6-88 order
       Region 4pjo B 89-95 disorder
 Evidence X-RAY 4pjo P Reference
       Region 4pjo P 1-5 disorder
       Region 4pjo P 6-88 order
       Region 4pjo P 89-95 disorder
 Evidence X-RAY 4pjo b Reference
       Region 4pjo b 1-5 disorder
       Region 4pjo b 6-53 order
       Region 4pjo b 54-59 disorder
       Region 4pjo b 60-89 order
       Region 4pjo b 90-95 disorder
 Evidence X-RAY 4pjo p Reference
       Region 4pjo p 1-5 disorder
       Region 4pjo p 6-91 order
       Region 4pjo p 92-95 disorder
Seq 1-174 Hetero nonamer : IID00138Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 3cw1 J Reference
       Region 3cw1 J 1-6 disorder
       Region 3cw1 J 7-47 order
       Region 3cw1 J 48-64 disorder
       Region 3cw1 J 65-86 order
       Region 3cw1 J 87-174 disorder
 Evidence X-RAY 3cw1 H Reference
       Region 3cw1 H 1-6 disorder
       Region 3cw1 H 7-47 order
       Region 3cw1 H 48-64 disorder
       Region 3cw1 H 65-87 order
       Region 3cw1 H 88-174 disorder
 Evidence X-RAY 3cw1 A Reference
       Region 3cw1 A 1-6 disorder
       Region 3cw1 A 7-47 order
       Region 3cw1 A 48-64 disorder
       Region 3cw1 A 65-87 order
       Region 3cw1 A 88-174 disorder
Seq 1-174 Hetero nonamer : IID00138Complex,IID00159Complex,IID00161Complex
 Evidence X-RAY 3cw1 I Reference
       Region 3cw1 I 1-7 disorder
       Region 3cw1 I 8-47 order
       Region 3cw1 I 48-64 disorder
       Region 3cw1 I 65-87 order
       Region 3cw1 I 88-174 disorder
Seq 1-229 Hetero nonamer : IID00159Complex,IID00161Complex
 Evidence X-RAY 3pgw Q Reference
       Region 3pgw Q 1-4 disorder
       Region 3pgw Q 5-53 order
       Region 3pgw Q 54-63 disorder
       Region 3pgw Q 64-90 order
       Region 3pgw Q 91-229 disorder
 Evidence X-RAY 3pgw B Reference
       Region 3pgw B 1-5 disorder
       Region 3pgw B 6-86 order
       Region 3pgw B 87-229 disorder
 
Prediction
NeProc
Disorder 1-8,54-240
Order 9-53
ProS 61-86,104-115,126-137
AlphaFold
Disorder 1-5,90-135,137-138,145-190,192-200,202-229,231-236
Order 6-89,136-136,139-144,191-191,201-201,230-230,237-240
Pfam Hmmer
PF01423 7-82 4.1e-21
SEG 98-117 ,151-164 ,169-240
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319).