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IID00144
UniprotP14859
ProteinPOU domain, class 2, transcription factor 1
GenePOU2F1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
743
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-200
 Evidence NMR Reference
       Region 1-200 disorder
Seq 278-439 Hetero dimer : IID00175Complex
 Evidence X-RAY 1cqt B Reference
       Region 1cqt B 278-283 disorder
       Region 1cqt B 284-317 order
       Region 1cqt B 318-318 disorder
       Region 1cqt B 319-354 order
       Region 1cqt B 355-379 disorder
       Region 1cqt B 380-403 order
       Region 1cqt B 404-404 disorder
       Region 1cqt B 405-439 order
 Evidence X-RAY 1cqt A Reference
       Region 1cqt A 278-280 disorder
       Region 1cqt A 281-354 order
       Region 1cqt A 355-379 disorder
       Region 1cqt A 380-439 order
Seq 280-438 Hetero dimer : IID50261Complex
 Evidence X-RAY 1gt0 C Reference
       Region 1gt0 C 280-281 disorder
       Region 1gt0 C 282-356 order
       Region 1gt0 C 357-374 disorder
       Region 1gt0 C 375-436 order
       Region 1gt0 C 437-438 disorder
Seq 280-438 Homo dimer :
 Evidence X-RAY 1hf0 B Reference
       Region 1hf0 B 280-284 disorder
       Region 1hf0 B 285-354 order
       Region 1hf0 B 355-379 disorder
       Region 1hf0 B 380-437 order
       Region 1hf0 B 438-438 disorder
 Evidence X-RAY 1hf0 A Reference
       Region 1hf0 A 280-284 disorder
       Region 1hf0 A 285-354 order
       Region 1hf0 A 355-379 disorder
       Region 1hf0 A 380-437 order
       Region 1hf0 A 438-438 disorder
Seq 280-439 Monomer :
 Evidence X-RAY 1e3o C Reference
       Region 1e3o C 280-354 order
       Region 1e3o C 355-381 disorder
       Region 1e3o C 382-438 order
 Evidence X-RAY 1oct C Reference
       Region 1oct C 284-354 order
       Region 1oct C 355-379 disorder
       Region 1oct C 380-439 order
Seq 280-442 Hetero dimer : IID00626Complex
 Evidence NMR 1o4x A Reference
       Region 1o4x A 280-354 order
       Region 1o4x A 355-384 disorder
       Region 1o4x A 385-438 order
       Region 1o4x A 439-442 disorder
Seq 284-354 Monomer :
 Evidence NMR 1pou A Reference
       Region 1pou A 284-354 order
Seq 378-437 Monomer :
 Evidence NMR 1pog A Reference
       Region 1pog A 378-437 order
       Region 1pog A 378-381 high_rmsd
       Region 1pog A 435-437 high_rmsd
Seqphosphorylation
    276-276 Phosphothreonine
    270-270 Phosphothreonine
    385-385 Phosphoserine
    283-283 Phosphoserine
    448-448 Phosphoserine
 
Prediction
NeProc
Disorder 1-297,355-380,437-743
Order 298-354,381-436
ProS 17-50,246-250,287-297,355-358,375-380,636-661,673-683,722-726
AlphaFold
Disorder 1-120,126-126,128-282,358-381,439-743
Order 121-125,127-127,283-357,382-438
Pfam Hmmer
PF00157 280-354 3.7e-54
PF00046 380-436 5.3e-23
SEG 81-99 ,117-159 ,176-191 ,210-231 ,248-263 ,277-289 ,350-371 ,439-449 ,458-486 ,505-560 ,566-602 ,687-708 ,727-742
Function
Function in SwissProt
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Biological Process
See also
Diagram with PDB data
SOX2/POU2F1/DNATERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Sox2/POU2F1/DNACrystal structure of a POU/HMG/DNA ternary complex
POU2AF1/POU2F1/DNACRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT