IID00144
Uniprot P14859
Protein POU domain, class 2, transcription factor 1
Gene POU2F1
Organism Homo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
743
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 278-439 Hetero dimer : IID00175 Complex
Region 1cqt B 278-283 disorder
Region 1cqt B 284-317 order
Region 1cqt B 318-318 disorder
Region 1cqt B 319-354 order
Region 1cqt B 355-379 disorder
Region 1cqt B 380-403 order
Region 1cqt B 404-404 disorder
Region 1cqt B 405-439 order
Region 1cqt A 278-280 disorder
Region 1cqt A 281-354 order
Region 1cqt A 355-379 disorder
Region 1cqt A 380-439 order
Seq 280-438 Hetero dimer : IID50261 Complex
Region 1gt0 C 280-281 disorder
Region 1gt0 C 282-356 order
Region 1gt0 C 357-374 disorder
Region 1gt0 C 375-436 order
Region 1gt0 C 437-438 disorder
Region 1hf0 B 280-284 disorder
Region 1hf0 B 285-354 order
Region 1hf0 B 355-379 disorder
Region 1hf0 B 380-437 order
Region 1hf0 B 438-438 disorder
Region 1hf0 A 280-284 disorder
Region 1hf0 A 285-354 order
Region 1hf0 A 355-379 disorder
Region 1hf0 A 380-437 order
Region 1hf0 A 438-438 disorder
Region 1e3o C 280-354 order
Region 1e3o C 355-381 disorder
Region 1e3o C 382-438 order
Region 1oct C 284-354 order
Region 1oct C 355-379 disorder
Region 1oct C 380-439 order
Seq 280-442 Hetero dimer : IID00626 Complex
Region 1o4x A 280-354 order
Region 1o4x A 355-384 disorder
Region 1o4x A 385-438 order
Region 1o4x A 439-442 disorder
Region 1pou A 284-354 order
Region 1pog A 378-437 order
Region 1pog A 378-381 high_rmsd
Region 1pog A 435-437 high_rmsd
Prediction
Disorder 1-297,355-380,437-743
ProS 17-50,246-250,287-297,355-358,375-380,636-661,673-683,722-726
Disorder 1-120,126-126,128-282,358-381,439-743
Order 121-125,127-127,283-357,382-438
SEG 81-99
,117-159
,176-191
,210-231
,248-263
,277-289
,350-371
,439-449
,458-486
,505-560
,566-602
,687-708
,727-742
Function
Function in SwissProt
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Biological Process
See also
Diagram with PDB data
SOX2/POU2F1/DNA TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2
TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1
REGULATORY ELEMENT
Sox2/POU2F1/DNA Crystal structure of a POU/HMG/DNA ternary complex
POU2AF1/POU2F1/DNA CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT