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IID00146
 UniprotP19419
ProteinETS domain-containing protein Elk-1
GeneELK1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
428
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-94 Homo dimer :
 Evidence X-RAY 1dux F Reference
       Region 1dux F 1-4 disorder
       Region 1dux F 5-90 order
       Region 1dux F 91-94 disorder
 Evidence X-RAY 1dux C Reference
       Region 1dux C 1-4 disorder
       Region 1dux C 5-90 order
       Region 1dux C 91-94 disorder
Seqdisorder 148-168
 Evidence CD Reference
       Region 148-168 disorder
Seq 378-385 Hetero tetramer : IID00643Complex
 Evidence X-RAY 5vvt D Reference
       Region 5vvt D 378-380 disorder
       Region 5vvt D 381-384 order
       Region 5vvt D 385-385 disorder
 Evidence X-RAY 5vvt B Reference
       Region 5vvt B 378-380 disorder
       Region 5vvt B 381-382 order
       Region 5vvt B 383-385 disorder
Seqphosphorylation
    422-422 Phosphoserine; by MAPK1
    417-417 Phosphothreonine; by MAPK1
    389-389 Phosphoserine; by MAPK1
    383-383 Phosphoserine; by MAPK1 and MAPK8
    368-368 Phosphothreonine; by MAPK1
    363-363 Phosphothreonine; by MAPK1
    353-353 Phosphothreonine; by MAPK1
    336-336 Phosphothreonine; by MAPK1
    324-324 Phosphoserine; by MAPK1
 
Prediction
NeProc
Disorder 98-428
Order 1-97
ProS 107-114,149-166,364-368,373-387,405-428
AlphaFold
Disorder 88-147,174-428
Order 1-87,148-173
Pfam Hmmer
PF00178 4-88 5e-62
SEG 167-217 ,244-259 ,319-334 ,350-375
Function
Function in SwissProt
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).