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IID00147
 UniprotP26368
ProteinSplicing factor U2AF 65 kDa subunit
GeneU2AF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
475
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 85-112 Hetero dimer : IID00205Complex
 Evidence X-RAY 1jmt B Reference
       Region 1jmt B 85-89 disorder
       Region 1jmt B 90-112 order
Seq 141-342 Monomer :
 Evidence NMR 2yh0 A Reference
       Region 2yh0 A 148-342 order
       Region 2yh0 A 231-256 high_rmsd
       Region 2yh0 A 338-342 high_rmsd
 Evidence NMR 2yh1 A Reference
       Region 2yh1 A 148-342 order
       Region 2yh1 A 233-256 high_rmsd
       Region 2yh1 A 339-342 high_rmsd
 Evidence X-RAY 5ev4 A Reference
       Region 5ev4 A 141-143 disorder
       Region 5ev4 A 144-340 order
       Region 5ev4 A 341-341 disorder
 Evidence X-RAY 5ev3 A Reference
       Region 5ev3 A 141-144 disorder
       Region 5ev3 A 145-340 order
       Region 5ev3 A 341-341 disorder
 Evidence X-RAY 5ev2 A Reference
       Region 5ev2 A 141-142 disorder
       Region 5ev2 A 143-340 order
       Region 5ev2 A 341-341 disorder
 Evidence X-RAY 5ev1 A Reference
       Region 5ev1 A 141-142 disorder
       Region 5ev1 A 143-340 order
       Region 5ev1 A 341-341 disorder
Seq 148-237 Monomer :
 Evidence NMR 1u2f A Reference
       Region 1u2f A 148-237 order
 Evidence X-RAY 2hzc A Reference
       Region 2hzc A 148-229 order
Seq 148-237,258-336 Homo dimer :
 Evidence X-RAY 3vam B Reference
       Region 3vam B 148-237 order
       Region 3vam B 258-336 order
 Evidence X-RAY 3vam A Reference
       Region 3vam A 148-237 order
       Region 3vam A 258-336 order
 Evidence X-RAY 3vak B Reference
       Region 3vak B 148-237 order
       Region 3vak B 258-336 order
 Evidence X-RAY 3vak A Reference
       Region 3vak A 148-237 order
       Region 3vak A 258-336 order
 Evidence X-RAY 3vaj B Reference
       Region 3vaj B 148-237 order
       Region 3vaj B 258-336 order
 Evidence X-RAY 3vaj A Reference
       Region 3vaj A 148-237 order
       Region 3vaj A 258-336 order
 Evidence X-RAY 3vai B Reference
       Region 3vai B 148-237 order
       Region 3vai B 258-336 order
 Evidence X-RAY 3vai A Reference
       Region 3vai A 148-237 order
       Region 3vai A 258-336 order
 Evidence X-RAY 3vah B Reference
       Region 3vah B 148-237 order
       Region 3vah B 258-336 order
 Evidence X-RAY 3vah A Reference
       Region 3vah A 148-237 order
       Region 3vah A 258-336 order
 Evidence X-RAY 3vag B Reference
       Region 3vag B 148-237 order
       Region 3vag B 258-336 order
 Evidence X-RAY 3vag A Reference
       Region 3vag A 148-237 order
       Region 3vag A 258-336 order
 Evidence X-RAY 3vaf B Reference
       Region 3vaf B 148-237 order
       Region 3vaf B 258-336 order
 Evidence X-RAY 3vaf A Reference
       Region 3vaf A 148-237 order
       Region 3vaf A 258-336 order
 Evidence X-RAY 4tu9 B Reference
       Region 4tu9 B 148-237 order
       Region 4tu9 B 258-336 order
 Evidence X-RAY 4tu9 A Reference
       Region 4tu9 A 148-237 order
       Region 4tu9 A 258-336 order
 Evidence X-RAY 4tu8 B Reference
       Region 4tu8 B 148-237 order
       Region 4tu8 B 258-336 order
 Evidence X-RAY 4tu8 A Reference
       Region 4tu8 A 148-237 order
       Region 4tu8 A 258-336 order
 Evidence X-RAY 4tu7 B Reference
       Region 4tu7 B 148-237 order
       Region 4tu7 B 258-336 order
 Evidence X-RAY 4tu7 A Reference
       Region 4tu7 A 148-237 order
       Region 4tu7 A 258-336 order
 Evidence X-RAY 2g4b A Reference
       Region 2g4b A 148-237 order
       Region 2g4b A 258-336 order
Seq 148-237,258-336 Homo tetramer :
 Evidence X-RAY 3val I Reference
       Region 3val I 148-237 order
       Region 3val I 258-336 order
 Evidence X-RAY 3val D Reference
       Region 3val D 148-237 order
       Region 3val D 258-336 order
 Evidence X-RAY 3val B Reference
       Region 3val B 148-237 order
       Region 3val B 258-336 order
 Evidence X-RAY 3val A Reference
       Region 3val A 148-237 order
       Region 3val A 258-336 order
Seq 258-342 Monomer :
 Evidence NMR 2u2f A Reference
       Region 2u2f A 258-342 order
Seq 372-475 Hetero dimer : IID00247Complex
 Evidence NMR 1opi A Reference
       Region 1opi A 372-475 order
       Region 1opi A 475-475 high_rmsd
 Evidence NMR 1o0p A Reference
       Region 1o0p A 372-475 order
Seq 372-475 Hetero dimer : IID00247Complex
 Evidence NMR 2m0g B Reference
       Region 2m0g B 372-475 order
 Evidence X-RAY 4fxw C Reference
       Region 4fxw C 375-420 order
       Region 4fxw C 421-421 disorder
       Region 4fxw C 422-475 order
 Evidence X-RAY 4fxw A Reference
       Region 4fxw A 375-475 order
Seqphosphorylation
    2-2 Phosphoserine
    79-79 Phosphoserine
    294-294 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    70-70 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-3,32-144,238-244,346-371
Order 4-31,145-237,245-340,372-475
ProS 1-3,32-36,42-48,72-76,89-102
AlphaFold
Disorder 1-4,17-98,101-101,114-128,130-144,337-372,475-475
Order 5-16,99-100,102-113,129-129,145-336,373-474
Pfam Hmmer
PF08648 1-154 0.00085
PF00076 151-226 4.8e-08
PF00076 261-332 1.4e-22
SEG 23-62 ,242-257 ,384-405
Function
Function in SwissProt
Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).