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IID00148
 UniprotP28324
ProteinETS domain-containing protein Elk-4
GeneELK4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
431
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-93 Monomer :
 Evidence X-RAY 1bc8 C Reference
       Region 1bc8 C 1-93 order
 Evidence X-RAY 1bc7 C Reference
       Region 1bc7 C 1-93 order
Seq 1-93 Hetero trimer : IID00140Complex
 Evidence X-RAY 1k6o A Reference
       Region 1k6o A 1-2 disorder
       Region 1k6o A 3-91 order
       Region 1k6o A 92-93 disorder
Seq 2-156 Hetero trimer : IID00140Complex
 Evidence X-RAY 1hbx H Reference
       Region 1hbx H 2-2 disorder
       Region 1hbx H 3-93 order
       Region 1hbx H 94-136 disorder
       Region 1hbx H 137-154 order
       Region 1hbx H 155-156 disorder
 Evidence X-RAY 1hbx G Reference
       Region 1hbx G 2-93 order
       Region 1hbx G 94-136 disorder
       Region 1hbx G 137-156 order
SeqProS possible 137-156 This region is called b-box. B-box in a homolog, Elk1 (IID00146) is disordered in the free state. (PubMed=9171356) Hetero trimer : IID00140Complex
       Region 1hbx G 137-156 order
       Region 1hbx H 137-154 order
Seqphosphorylation
    180-180 Phosphoserine
 
Prediction
NeProc
Disorder 94-431
Order 1-93
ProS 94-94,96-103,138-144,373-382,398-431
AlphaFold
Disorder 1-2,96-135,157-431
Order 3-95,136-156
Pfam Hmmer
PF00178 4-87 2.7e-56
SEG 107-117 ,146-159 ,207-222 ,335-349
Function
Function in SwissProt
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.