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IID00152
 UniprotP52272
ProteinHeterogeneous nuclear ribonucleoprotein M
GeneHNRNPM
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
730
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 41-70 Hetero dimer : IID00094Complex
 Evidence X-RAY 2ot8 C Reference
       Region 2ot8 C 41-50 disorder
       Region 2ot8 C 51-53 order
       Region 2ot8 C 54-54 disorder
       Region 2ot8 C 55-68 order
       Region 2ot8 C 69-70 disorder
Seq 41-70 Hetero dimer : IID00094Complex
 Evidence X-RAY 2ot8 D Reference
       Region 2ot8 D 41-49 disorder
       Region 2ot8 D 50-69 order
       Region 2ot8 D 70-70 disorder
Seq 196-296 Monomer :
 Evidence NMR 2do0 A Reference
       Region 2do0 A 196-296 order
       Region 2do0 A 196-202 high_rmsd
       Region 2do0 A 282-296 high_rmsd
Seq 652-730 Monomer :
 Evidence NMR 2dh9 A Reference
       Region 2dh9 A 655-730 order
       Region 2dh9 A 730-730 high_rmsd
 Evidence NMR 2dgv A Reference
       Region 2dgv A 652-730 order
SeqProS possible 50-69 Nuclear Localization Signal (NLS) Hetero dimer : IID00094Complex
       Region 2ot8 D 50-69 order
SeqProS possible 50-69 Nuclear Localization Signal (NLS) Hetero dimer : IID00094Complex
       Region 2ot8 C 51-53 order
       Region 2ot8 C 55-68 order
Seqphosphorylation
    29-29 Phosphoserine
    86-86 Phosphoserine
    204-204 Phosphoserine
    365-365 Phosphoserine
    377-377 Phosphoserine
    397-397 Phosphoserine
    432-432 Phosphoserine
    452-452 Phosphoserine
    468-468 Phosphoserine
    481-481 Phosphoserine
    528-528 Phosphoserine
    575-575 Phosphoserine
    588-588 Phosphoserine
    618-618 Phosphoserine
    633-633 Phosphoserine
    637-637 Phosphoserine
    665-665 Phosphothreonine
    701-701 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    134-134 N6-acetyllysine; alternate
    277-277 N6-acetyllysine; alternate
    672-672 N6-acetyllysine
    698-698 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-68,151-201,290-650
Order 69-150,202-289,651-730
ProS 151-158,166-192,290-318,325-337,361-373,390-396,443-447,461-464,478-484,492-495,501-506,530-534,540-552,597-632
AlphaFold
Disorder 1-70,108-108,148-191,198-200,280-652,728-730
Order 71-107,109-147,192-197,201-279,653-727
Pfam Hmmer
PF00076 73-144 1.2e-18
PF00076 206-276 8.2e-17
PF00076 655-724 3.8e-24
SEG 2-13 ,163-194 ,297-314 ,346-361 ,390-396 ,592-603 ,607-617 ,630-643
Function
Function in SwissProt
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.