Search Keyword:


Search option:


IID00154
 UniprotP54198
ProteinProtein HIRA
GeneHIRA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1017
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 425-472 Hetero dimer : IID00182Complex
 Evidence X-RAY 2i32 F Reference
       Region 2i32 F 425-448 disorder
       Region 2i32 F 449-464 order
       Region 2i32 F 465-472 disorder
 Evidence X-RAY 2i32 E Reference
       Region 2i32 E 425-445 disorder
       Region 2i32 E 446-466 order
       Region 2i32 E 467-472 disorder
SeqProS possible 446-466 This region contains the binding motif GRRRIxPLxI Hetero dimer : IID00182Complex
       Region 2i32 E 446-466 order
       Region 2i32 F 449-464 order
Seqphosphorylation
    675-675 Phosphoserine
    111-111 Phosphoserine
    549-549 Phosphoserine
    555-555 Phosphothreonine; by CDK2
    557-557 Phosphoserine
    576-576 Phosphothreonine
    584-584 Phosphoserine
    586-586 Phosphothreonine
    610-610 Phosphoserine
    611-611 Phosphoserine
    612-612 Phosphoserine
    614-614 Phosphoserine
    661-661 Phosphoserine
    687-687 Phosphoserine
 
Prediction
NeProc
Disorder 380-668,873-903
Order 1-102,115-286,293-379,669-872,904-1017
ProS 397-402,451-457,462-468,529-534,646-652,668-668,883-896
AlphaFold
Disorder 102-116,221-221,285-294,380-455,457-681,819-821,862-863,875-882,892-902,968-972,1016-1017
Order 1-101,117-220,222-284,295-379,456-456,682-818,822-861,864-874,883-891,903-967,973-1015
Pfam Hmmer
PF00400 60-98 1.7e-08
PF00400 121-159 5.2e-11
PF00400 164-202 2.5e-07
PF00400 258-313 3.9e-05
PF07569 763-962 1.8e-96
SEG 275-287 ,405-412 ,493-509 ,601-616 ,628-643 ,705-716 ,767-778 ,981-991
Function
Function in SwissProt
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.