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IID00155
 UniprotP54274
ProteinTelomeric repeat-binding factor 1
GeneTERF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
439
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-55 Hetero tetramer : IID50231Complex
 Evidence X-RAY 5hkp D Reference
       Region 5hkp D 1-10 disorder
       Region 5hkp D 11-21 order
       Region 5hkp D 22-55 disorder
 Evidence X-RAY 5hkp C Reference
       Region 5hkp C 1-10 disorder
       Region 5hkp C 11-22 order
       Region 5hkp C 23-55 disorder
Seq 58-268 Hetero tetramer : IID00180Complex
 Evidence X-RAY 3bqo A Reference
       Region 3bqo A 58-61 disorder
       Region 3bqo A 62-201 order
       Region 3bqo A 202-206 disorder
       Region 3bqo A 207-268 order
Seq 58-268 Hetero dimer : IID00630Complex
 Evidence X-RAY 3l82 A Reference
       Region 3l82 A 58-63 disorder
       Region 3l82 A 64-266 order
       Region 3l82 A 267-268 disorder
Seq 62-265 Homo dimer :
 Evidence X-RAY 1h6o A Reference
       Region 1h6o A 62-138 order
       Region 1h6o A 139-140 disorder
       Region 1h6o A 141-204 order
       Region 1h6o A 205-211 disorder
       Region 1h6o A 212-265 order
Seq 62-266 Hetero tetramer : Q8NA31
 Evidence X-RAY 5xup B Reference
       Region 5xup B 65-201 order
       Region 5xup B 202-206 disorder
       Region 5xup B 207-265 order
       Region 5xup B 266-266 disorder
 Evidence X-RAY 5xup A Reference
       Region 5xup A 65-266 order
 Evidence X-RAY 5wir B Reference
       Region 5wir B 62-265 order
 Evidence X-RAY 5wir A Reference
       Region 5wir A 62-265 order
Seq 371-439 Monomer :
 Evidence NMR 1iv6 A Reference
       Region 1iv6 A 371-377 disorder
       Region 1iv6 A 378-434 order
       Region 1iv6 A 378-378 high_rmsd
       Region 1iv6 A 434-434 high_rmsd
       Region 1iv6 A 435-439 disorder
 Evidence NMR 1ity A Reference
       Region 1ity A 371-372 disorder
       Region 1ity A 371-382 disorder
       Region 1ity A 373-439 order
       Region 1ity A 373-381 high_rmsd
       Region 1ity A 383-439 order
       Region 1ity A 434-439 high_rmsd
 Evidence NMR 1ba5 A Reference
       Region 1ba5 A 378-430 order
       Region 1ba5 A 378-382 disorder
       Region 1ba5 A 378-381 high_rmsd
       Region 1ba5 A 383-430 order
       Region 1ba5 A 430-430 high_rmsd
Seq 379-431 Homo dimer :
 Evidence X-RAY 1w0t B Reference
       Region 1w0t B 379-430 order
       Region 1w0t B 431-431 disorder
 Evidence X-RAY 1w0t A Reference
       Region 1w0t A 379-430 order
       Region 1w0t A 431-431 disorder
SeqProS predicted 11-21 The unbound state of this region is predicted to be disordered by DICHOT, Foldindex and MobiDB. Hetero tetramer : IID50231Complex
       Region 5hkp C 11-22 order
       Region 5hkp D 11-21 order
SeqProS verified 139-140 Hetero tetramer : IID00180Complex
       Region 3bqo A 62-201 order
       Region 1h6o A 139-140 disorder
SeqProS verified 139-140 Hetero tetramer : Q8NA31
       Region 5wir A 62-265 order
       Region 5wir B 62-265 order
       Region 5xup A 65-266 order
       Region 5xup B 65-201 order
       Region 1h6o A 139-140 disorder
SeqProS verified 378-382 This region binds upon DNA. :
       Region 1iv6 A 378-434 order
       Region 1ity A 371-382 disorder
Seqphosphorylation
    11-11 Phosphoserine
    219-219 Phosphoserine; by ATM
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-67,258-378,436-439
Order 68-257,379-435
ProS 13-20,34-49,287-313,318-378
AlphaFold
Disorder 1-61,163-165,204-207,275-380,432-439
Order 62-162,166-203,208-274,381-431
Pfam Hmmer
PF08558 72-257 5.9e-134
PF00249 380-428 1.9e-09
SEG 36-76
Function
Function in SwissProt
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.