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IID00156
 UniprotP62304
ProteinSmall nuclear ribonucleoprotein E
GeneSNRPE
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
92
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3cw1 Y Reference
       Region 3cw1 Y 1-17 disorder
       Region 3cw1 Y 18-92 order
 Evidence X-RAY 3cw1 W Reference
       Region 3cw1 W 1-17 disorder
       Region 3cw1 W 18-92 order
 Evidence X-RAY 3cw1 E Reference
       Region 3cw1 E 1-17 disorder
       Region 3cw1 E 18-92 order
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3cw1 X Reference
       Region 3cw1 X 1-17 disorder
       Region 3cw1 X 18-92 order
Seq 1-92 Hetero hexamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 4f7u H Reference
       Region 4f7u H 1-13 disorder
       Region 4f7u H 14-91 order
       Region 4f7u H 92-92 disorder
 Evidence X-RAY 4f7u E Reference
       Region 4f7u E 1-12 disorder
       Region 4f7u E 13-90 order
       Region 4f7u E 91-92 disorder
Seq 1-92 Hetero 36mer : IID00138Complex,IID00157Complex,IID00158Complex
 Evidence X-RAY 4pjo E Reference
       Region 4pjo E 1-13 disorder
       Region 4pjo E 14-90 order
       Region 4pjo E 91-92 disorder
 Evidence X-RAY 4pjo S Reference
       Region 4pjo S 1-13 disorder
       Region 4pjo S 14-90 order
       Region 4pjo S 91-92 disorder
Seq 1-92 Hetero nonamer : IID00157Complex,IID00158Complex
 Evidence X-RAY 3pgw H Reference
       Region 3pgw H 1-89 order
       Region 3pgw H 90-92 disorder
 Evidence X-RAY 3pgw E Reference
       Region 3pgw E 1-6 disorder
       Region 3pgw E 7-90 order
       Region 3pgw E 91-92 disorder
 
Prediction
NeProc
Disorder 1-12
Order 13-92
ProS 1-6
AlphaFold
Disorder 1-9,92-92
Order 10-91
Pfam Hmmer
PF01423 23-89 1.1e-20
SEG 5-16
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). May indirectly play a role in hair development (PubMed:23246290).