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IID00157
 UniprotP62306
ProteinSmall nuclear ribonucleoprotein F
GeneSNRPF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
86
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-75 Hetero 36mer : IID00138Complex,IID00143Complex,IID00156Complex,IID00158Complex,IID00160Complex
 Evidence X-RAY 4pjo F Reference
       Region 4pjo F 1-2 disorder
       Region 4pjo F 3-75 order
 Evidence X-RAY 4pjo T Reference
       Region 4pjo T 1-1 disorder
       Region 4pjo T 2-75 order
 Evidence X-RAY 4pjo f Reference
       Region 4pjo f 1-1 disorder
       Region 4pjo f 2-75 order
Seq 1-86 Hetero nonamer : IID00156Complex,IID00160Complex
 Evidence X-RAY 3cw1 2 Reference
       Region 3cw1 2 1-5 disorder
       Region 3cw1 2 6-81 order
       Region 3cw1 2 82-86 disorder
 Evidence X-RAY 3cw1 Z Reference
       Region 3cw1 Z 1-5 disorder
       Region 3cw1 Z 6-75 order
       Region 3cw1 Z 76-86 disorder
 Evidence X-RAY 3cw1 F Reference
       Region 3cw1 F 1-5 disorder
       Region 3cw1 F 6-81 order
       Region 3cw1 F 82-86 disorder
Seq 1-86 Hetero nonamer : IID00156Complex,IID00160Complex
 Evidence X-RAY 3cw1 1 Reference
       Region 3cw1 1 1-6 disorder
       Region 3cw1 1 7-81 order
       Region 3cw1 1 82-86 disorder
Seq 1-86 Hetero hexamer : IID00156Complex,IID00160Complex
 Evidence X-RAY 4f7u I Reference
       Region 4f7u I 1-2 disorder
       Region 4f7u I 3-76 order
       Region 4f7u I 77-86 disorder
 Evidence X-RAY 4f7u F Reference
       Region 4f7u F 1-3 disorder
       Region 4f7u F 4-76 order
       Region 4f7u F 77-86 disorder
Seq 1-86 Hetero nonamer : IID00138Complex,IID00156Complex,IID00160Complex
 Evidence X-RAY 3pgw I Reference
       Region 3pgw I 1-1 disorder
       Region 3pgw I 2-75 order
       Region 3pgw I 76-86 disorder
 Evidence X-RAY 3pgw F Reference
       Region 3pgw F 1-1 disorder
       Region 3pgw F 2-86 order
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-3,77-86
Order 4-76
ProS 82-86
AlphaFold
Disorder 1-1,78-86
Order 2-77
Pfam Hmmer
PF01423 9-74 1.9e-25
SEG 76-86
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).