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IID00159
 UniprotP62314
ProteinSmall nuclear ribonucleoprotein Sm D1
GeneSNRPD1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
119
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-119 Hetero hexamer : A1ZAW5,IID00160Complex
 Evidence X-RAY 4f7u C Reference
       Region 4f7u C 1-1 disorder
       Region 4f7u C 2-82 order
       Region 4f7u C 83-119 disorder
 Evidence X-RAY 4f7u A Reference
       Region 4f7u A 1-82 order
       Region 4f7u A 83-119 disorder
Seq 1-119 Hetero nonamer : IID00143Complex,IID00160Complex
 Evidence X-RAY 3cw1 N Reference
       Region 3cw1 N 1-1 disorder
       Region 3cw1 N 2-77 order
       Region 3cw1 N 78-119 disorder
Seq 1-119 Hetero nonamer : IID00138Complex,IID00143Complex,IID00160Complex
 Evidence X-RAY 3pgw U Reference
       Region 3pgw U 1-85 order
       Region 3pgw U 86-119 disorder
 Evidence X-RAY 3pgw X Reference
       Region 3pgw X 1-85 order
       Region 3pgw X 86-119 disorder
Seq 1-119 Hetero dimer : IID00160Complex
 Evidence X-RAY 1b34 A Reference
       Region 1b34 A 1-1 disorder
       Region 1b34 A 2-81 order
       Region 1b34 A 82-119 disorder
Seq 1-119 Hetero nonamer : IID00143Complex,IID00160Complex
 Evidence X-RAY 3cw1 O Reference
       Region 3cw1 O 1-1 disorder
       Region 3cw1 O 2-78 order
       Region 3cw1 O 79-119 disorder
 Evidence X-RAY 3cw1 M Reference
       Region 3cw1 M 1-1 disorder
       Region 3cw1 M 2-78 order
       Region 3cw1 M 79-119 disorder
 Evidence X-RAY 3cw1 B Reference
       Region 3cw1 B 1-1 disorder
       Region 3cw1 B 2-78 order
       Region 3cw1 B 79-119 disorder
Seq 2-85 Hetero 36mer : IID00138Complex,IID00143Complex,IID00160Complex
 Evidence X-RAY 4pjo C Reference
       Region 4pjo C 2-82 order
       Region 4pjo C 83-85 disorder
 Evidence X-RAY 4pjo Q Reference
       Region 4pjo Q 2-82 order
       Region 4pjo Q 83-85 disorder
 Evidence X-RAY 4pjo c Reference
       Region 4pjo c 2-83 order
       Region 4pjo c 84-85 disorder
 
Prediction
NeProc
Disorder 1-2,84-119
Order 3-83
ProS 1-2,99-106
AlphaFold
Disorder 88-119
Order 1-87
Pfam Hmmer
PF01423 5-70 2.1e-20
SEG 97-119
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable).