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IID00160
 UniprotP62316
ProteinSmall nuclear ribonucleoprotein Sm D2
GeneSNRPD2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
118
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-118 Hetero hexamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 4f7u D Reference
       Region 4f7u D 1-15 disorder
       Region 4f7u D 16-76 order
       Region 4f7u D 77-89 disorder
       Region 4f7u D 90-113 order
       Region 4f7u D 114-118 disorder
 Evidence X-RAY 4f7u B Reference
       Region 4f7u B 1-21 disorder
       Region 4f7u B 22-76 order
       Region 4f7u B 77-89 disorder
       Region 4f7u B 90-114 order
       Region 4f7u B 115-118 disorder
Seq 1-118 Hetero nonamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 3cw1 Q Reference
       Region 3cw1 Q 1-10 disorder
       Region 3cw1 Q 11-76 order
       Region 3cw1 Q 77-91 disorder
       Region 3cw1 Q 92-114 order
       Region 3cw1 Q 115-118 disorder
Seq 1-118 Hetero nonamer : IID00138Complex,IID00157Complex,IID00159Complex
 Evidence X-RAY 3pgw V Reference
       Region 3pgw V 1-1 disorder
       Region 3pgw V 2-76 order
       Region 3pgw V 77-89 disorder
       Region 3pgw V 90-117 order
       Region 3pgw V 118-118 disorder
 Evidence X-RAY 3pgw Y Reference
       Region 3pgw Y 1-1 disorder
       Region 3pgw Y 2-112 order
       Region 3pgw Y 113-118 disorder
Seq 1-118 Hetero 36mer : IID00138Complex,IID00157Complex,IID00159Complex
 Evidence X-RAY 4pjo D Reference
       Region 4pjo D 1-9 disorder
       Region 4pjo D 10-77 order
       Region 4pjo D 78-86 disorder
       Region 4pjo D 87-116 order
       Region 4pjo D 117-118 disorder
 Evidence X-RAY 4pjo R Reference
       Region 4pjo R 1-9 disorder
       Region 4pjo R 10-77 order
       Region 4pjo R 78-88 disorder
       Region 4pjo R 89-116 order
       Region 4pjo R 117-118 disorder
 Evidence X-RAY 4pjo d Reference
       Region 4pjo d 1-12 disorder
       Region 4pjo d 13-77 order
       Region 4pjo d 78-87 disorder
       Region 4pjo d 88-114 order
       Region 4pjo d 115-118 disorder
 Evidence X-RAY 4pjo r Reference
       Region 4pjo r 78-87 disorder
       Region 4pjo r 88-114 order
       Region 4pjo r 115-118 disorder
Seq 1-118 Hetero dimer : IID00159Complex
 Evidence X-RAY 1b34 B Reference
       Region 1b34 B 1-25 disorder
       Region 1b34 B 26-73 order
       Region 1b34 B 74-92 disorder
       Region 1b34 B 93-118 order
Seq 1-118 Hetero nonamer : IID00157Complex,IID00159Complex
 Evidence X-RAY 3cw1 R Reference
       Region 3cw1 R 1-10 disorder
       Region 3cw1 R 11-73 order
       Region 3cw1 R 74-91 disorder
       Region 3cw1 R 92-113 order
       Region 3cw1 R 114-118 disorder
 Evidence X-RAY 3cw1 P Reference
       Region 3cw1 P 1-10 disorder
       Region 3cw1 P 11-75 order
       Region 3cw1 P 76-91 disorder
       Region 3cw1 P 92-112 order
       Region 3cw1 P 113-118 disorder
 Evidence X-RAY 3cw1 C Reference
       Region 3cw1 C 1-10 disorder
       Region 3cw1 C 11-75 order
       Region 3cw1 C 76-91 disorder
       Region 3cw1 C 92-114 order
       Region 3cw1 C 115-118 disorder
Seqphosphorylation
    12-12 Phosphothreonine
    9-9 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-25,114-118
Order 26-113
ProS 1-25,114-118
AlphaFold
Disorder 1-1,114-118
Order 2-113
Pfam Hmmer
PF01423 30-111 2e-16
SEG 77-90
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077).