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IID00161
 UniprotP62318
ProteinSmall nuclear ribonucleoprotein Sm D3
GeneSNRPD3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
126
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-75 Hetero dimer : IID00143Complex
 Evidence X-RAY 1d3b K Reference
       Region 1d3b K 1-4 disorder
       Region 1d3b K 5-75 order
 Evidence X-RAY 1d3b I Reference
       Region 1d3b I 1-2 disorder
       Region 1d3b I 3-75 order
 Evidence X-RAY 1d3b G Reference
       Region 1d3b G 1-2 disorder
       Region 1d3b G 3-75 order
 Evidence X-RAY 1d3b E Reference
       Region 1d3b E 1-1 disorder
       Region 1d3b E 2-75 order
 Evidence X-RAY 1d3b C Reference
       Region 1d3b C 1-4 disorder
       Region 1d3b C 5-75 order
 Evidence X-RAY 1d3b A Reference
       Region 1d3b A 1-3 disorder
       Region 1d3b A 4-75 order
Seq 1-126 Hetero nonamer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 3cw1 T Reference
       Region 3cw1 T 1-5 disorder
       Region 3cw1 T 6-81 order
       Region 3cw1 T 82-126 disorder
Seq 1-126 Hetero nonamer : IID00143Complex,IID00158Complex
 Evidence X-RAY 3pgw W Reference
       Region 3pgw W 1-2 disorder
       Region 3pgw W 3-94 order
       Region 3pgw W 95-126 disorder
 Evidence X-RAY 3pgw Z Reference
       Region 3pgw Z 1-4 disorder
       Region 3pgw Z 5-84 order
       Region 3pgw Z 85-126 disorder
Seq 1-126 Hetero 36mer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 4pjo A Reference
       Region 4pjo A 1-84 order
       Region 4pjo A 85-126 disorder
 Evidence X-RAY 4pjo O Reference
       Region 4pjo O 1-1 disorder
       Region 4pjo O 2-83 order
       Region 4pjo O 84-126 disorder
 Evidence X-RAY 4pjo a Reference
       Region 4pjo a 1-1 disorder
       Region 4pjo a 2-84 order
       Region 4pjo a 85-126 disorder
 Evidence X-RAY 4pjo o Reference
       Region 4pjo o 1-2 disorder
       Region 4pjo o 3-83 order
       Region 4pjo o 84-126 disorder
Seq 1-126 Hetero nonamer : IID00138Complex,IID00139Complex,IID00143Complex,IID00158Complex
 Evidence X-RAY 3cw1 U Reference
       Region 3cw1 U 1-5 disorder
       Region 3cw1 U 6-81 order
       Region 3cw1 U 82-126 disorder
 Evidence X-RAY 3cw1 S Reference
       Region 3cw1 S 1-5 disorder
       Region 3cw1 S 6-81 order
       Region 3cw1 S 82-126 disorder
 Evidence X-RAY 3cw1 D Reference
       Region 3cw1 D 1-5 disorder
       Region 3cw1 D 6-81 order
       Region 3cw1 D 82-126 disorder
Seq 54-63 Hetero trimer : P18465
 Evidence X-RAY 3vri C Reference
       Region 3vri C 54-63 order
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 86-126
Order 1-85
ProS 100-122
AlphaFold
Disorder 1-1,85-100,109-126
Order 2-84,101-108
Pfam Hmmer
PF01423 8-73 3.4e-17
SEG 110-119
Function
Function in SwissProt
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).