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IID00163
 UniprotQ00987
ProteinE3 ubiquitin-protein ligase Mdm2
GeneMDM2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
491
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-125 Monomer :
 Evidence NMR 1z1m A Reference
       Region 1z1m A 1-118 order
       Region 1z1m A 1-22 high_rmsd
       Region 1z1m A 107-118 high_rmsd
 Evidence X-RAY 5ln2 A Reference
       Region 5ln2 A 17-111 order
 Evidence X-RAY 5laz A Reference
       Region 5laz A 18-111 order
 Evidence X-RAY 5law A Reference
       Region 5law A 18-111 order
 Evidence X-RAY 4zyi A Reference
       Region 4zyi A 17-19 disorder
       Region 4zyi A 20-42 order
       Region 4zyi A 43-43 disorder
       Region 4zyi A 44-110 order
       Region 4zyi A 111-111 disorder
 Evidence X-RAY 4zyf A Reference
       Region 4zyf A 17-17 disorder
       Region 4zyf A 18-110 order
       Region 4zyf A 111-111 disorder
 Evidence X-RAY 4zyc C Reference
       Region 4zyc C 17-25 disorder
       Region 4zyc C 26-110 order
       Region 4zyc C 111-111 disorder
 Evidence X-RAY 4zyc B Reference
       Region 4zyc B 17-25 disorder
       Region 4zyc B 26-111 order
 Evidence X-RAY 4zyc A Reference
       Region 4zyc A 17-24 disorder
       Region 4zyc A 25-108 order
       Region 4zyc A 109-111 disorder
 Evidence X-RAY 4zgk B Reference
       Region 4zgk B 18-114 order
 Evidence X-RAY 4zgk A Reference
       Region 4zgk A 18-110 order
       Region 4zgk A 111-114 disorder
 Evidence X-RAY 4zfi D Reference
       Region 4zfi D 18-18 disorder
       Region 4zfi D 19-111 order
       Region 4zfi D 112-113 disorder
 Evidence X-RAY 4zfi C Reference
       Region 4zfi C 18-110 order
       Region 4zfi C 111-113 disorder
 Evidence X-RAY 4zfi B Reference
       Region 4zfi B 18-113 order
 Evidence X-RAY 4zfi A Reference
       Region 4zfi A 18-112 order
       Region 4zfi A 113-113 disorder
 Evidence X-RAY 5z02 A Reference
       Region 5z02 A 24-111 order
       Region 5z02 A 112-112 disorder
 Evidence X-RAY 5xxk B Reference
       Region 5xxk B 6-17 disorder
       Region 5xxk B 18-111 order
       Region 5xxk B 112-125 disorder
 Evidence X-RAY 5xxk A Reference
       Region 5xxk A 6-17 disorder
       Region 5xxk A 18-112 order
       Region 5xxk A 113-125 disorder
 Evidence X-RAY 4wt2 A Reference
       Region 4wt2 A 6-110 order
 Evidence X-RAY 3w69 B Reference
       Region 3w69 B 25-109 order
 Evidence X-RAY 3w69 A Reference
       Region 3w69 A 25-109 order
 Evidence X-RAY 3vzv B Reference
       Region 3vzv B 25-109 order
 Evidence X-RAY 3vzv A Reference
       Region 3vzv A 25-109 order
 Evidence X-RAY 4ue1 B Reference
       Region 4ue1 B 17-111 order
       Region 4ue1 B 112-125 disorder
 Evidence X-RAY 4ue1 A Reference
       Region 4ue1 A 17-111 order
       Region 4ue1 A 112-125 disorder
 Evidence X-RAY 4ue1 D Reference
       Region 4ue1 D 17-112 order
       Region 4ue1 D 113-125 disorder
 Evidence X-RAY 4ue1 C Reference
       Region 4ue1 C 17-112 order
       Region 4ue1 C 113-125 disorder
 Evidence X-RAY 3tu1 A Reference
       Region 3tu1 A 18-110 order
       Region 3tu1 A 111-125 disorder
 Evidence X-RAY 5trf E Reference
       Region 5trf E 10-110 order
       Region 5trf E 111-118 disorder
 Evidence X-RAY 5trf D Reference
       Region 5trf D 10-68 order
       Region 5trf D 69-71 disorder
       Region 5trf D 72-110 order
       Region 5trf D 111-118 disorder
 Evidence X-RAY 5trf C Reference
       Region 5trf C 10-10 disorder
       Region 5trf C 11-110 order
       Region 5trf C 111-118 disorder
 Evidence X-RAY 5trf B Reference
       Region 5trf B 10-67 order
       Region 5trf B 68-70 disorder
       Region 5trf B 71-112 order
       Region 5trf B 113-118 disorder
 Evidence X-RAY 5trf A Reference
       Region 5trf A 10-67 order
       Region 5trf A 68-71 disorder
       Region 5trf A 72-111 order
       Region 5trf A 112-118 disorder
 Evidence X-RAY 3tpx E Reference
       Region 3tpx E 25-108 order
       Region 3tpx E 109-109 disorder
 Evidence X-RAY 3tpx C Reference
       Region 3tpx C 25-25 disorder
       Region 3tpx C 26-108 order
       Region 3tpx C 109-109 disorder
 Evidence X-RAY 3tpx A Reference
       Region 3tpx A 25-25 disorder
       Region 3tpx A 26-109 order
 Evidence X-RAY 3tj2 C Reference
       Region 3tj2 C 18-110 order
       Region 3tj2 C 111-111 disorder
 Evidence X-RAY 3tj2 A Reference
       Region 3tj2 A 18-20 disorder
       Region 3tj2 A 21-110 order
       Region 3tj2 A 111-111 disorder
 Evidence NMR 2ruh A Reference
       Region 2ruh A 6-102 order
       Region 2ruh A 6-23 high_rmsd
 Evidence X-RAY 4qoc K Reference
       Region 4qoc K 17-111 order
 Evidence X-RAY 4qoc I Reference
       Region 4qoc I 17-110 order
       Region 4qoc I 111-111 disorder
 Evidence X-RAY 4qoc G Reference
       Region 4qoc G 17-17 disorder
       Region 4qoc G 18-111 order
 Evidence X-RAY 4qoc E Reference
       Region 4qoc E 17-64 order
       Region 4qoc E 65-65 disorder
       Region 4qoc E 66-111 order
 Evidence X-RAY 4qoc C Reference
       Region 4qoc C 17-18 disorder
       Region 4qoc C 19-110 order
       Region 4qoc C 111-111 disorder
 Evidence X-RAY 4qoc A Reference
       Region 4qoc A 17-18 disorder
       Region 4qoc A 19-110 order
       Region 4qoc A 111-111 disorder
 Evidence X-RAY 4qo4 A Reference
       Region 4qo4 A 17-17 disorder
       Region 4qo4 A 18-68 order
       Region 4qo4 A 69-72 disorder
       Region 4qo4 A 73-110 order
       Region 4qo4 A 111-111 disorder
 Evidence X-RAY 4oq3 D Reference
       Region 4oq3 D 17-17 disorder
       Region 4oq3 D 18-107 order
       Region 4oq3 D 108-111 disorder
 Evidence X-RAY 4oq3 C Reference
       Region 4oq3 C 17-17 disorder
       Region 4oq3 C 18-110 order
       Region 4oq3 C 111-111 disorder
 Evidence X-RAY 4oq3 B Reference
       Region 4oq3 B 17-17 disorder
       Region 4oq3 B 18-108 order
       Region 4oq3 B 109-111 disorder
 Evidence X-RAY 4oq3 A Reference
       Region 4oq3 A 17-17 disorder
       Region 4oq3 A 18-110 order
       Region 4oq3 A 111-111 disorder
 Evidence X-RAY 4ogv C Reference
       Region 4ogv C 17-17 disorder
       Region 4ogv C 18-68 order
       Region 4ogv C 69-72 disorder
       Region 4ogv C 73-110 order
       Region 4ogv C 111-111 disorder
 Evidence X-RAY 4ogv B Reference
       Region 4ogv B 17-17 disorder
       Region 4ogv B 18-68 order
       Region 4ogv B 69-72 disorder
       Region 4ogv B 73-110 order
       Region 4ogv B 111-111 disorder
 Evidence X-RAY 4ogv A Reference
       Region 4ogv A 17-17 disorder
       Region 4ogv A 18-68 order
       Region 4ogv A 69-72 disorder
       Region 4ogv A 73-110 order
       Region 4ogv A 111-111 disorder
 Evidence X-RAY 4ogt A Reference
       Region 4ogt A 6-11 disorder
       Region 4ogt A 12-110 order
 Evidence X-RAY 4ogn A Reference
       Region 4ogn A 6-10 disorder
       Region 4ogn A 11-110 order
 Evidence X-RAY 4odf A Reference
       Region 4odf A 6-11 disorder
       Region 4odf A 12-110 order
 Evidence X-RAY 4ode A Reference
       Region 4ode A 6-110 order
 Evidence X-RAY 4occ E Reference
       Region 4occ E 17-17 disorder
       Region 4occ E 18-110 order
       Region 4occ E 111-111 disorder
 Evidence X-RAY 4occ C Reference
       Region 4occ C 17-18 disorder
       Region 4occ C 19-110 order
       Region 4occ C 111-111 disorder
 Evidence X-RAY 4occ A Reference
       Region 4occ A 17-17 disorder
       Region 4occ A 18-110 order
       Region 4occ A 111-111 disorder
 Evidence X-RAY 4oba C Reference
       Region 4oba C 17-18 disorder
       Region 4oba C 19-68 order
       Region 4oba C 69-72 disorder
       Region 4oba C 73-110 order
       Region 4oba C 111-111 disorder
 Evidence X-RAY 4oba B Reference
       Region 4oba B 17-18 disorder
       Region 4oba B 19-68 order
       Region 4oba B 69-72 disorder
       Region 4oba B 73-110 order
       Region 4oba B 111-111 disorder
 Evidence X-RAY 4oba A Reference
       Region 4oba A 17-18 disorder
       Region 4oba A 19-68 order
       Region 4oba A 69-72 disorder
       Region 4oba A 73-110 order
       Region 4oba A 111-111 disorder
 Evidence X-RAY 4oas E Reference
       Region 4oas E 17-17 disorder
       Region 4oas E 18-110 order
       Region 4oas E 111-111 disorder
 Evidence X-RAY 4oas C Reference
       Region 4oas C 17-18 disorder
       Region 4oas C 19-110 order
       Region 4oas C 111-111 disorder
 Evidence X-RAY 4oas A Reference
       Region 4oas A 17-17 disorder
       Region 4oas A 18-110 order
       Region 4oas A 111-111 disorder
 Evidence X-RAY 4mdq A Reference
       Region 4mdq A 25-110 order
 Evidence X-RAY 4mdn A Reference
       Region 4mdn A 18-110 order
 Evidence NMR 2lzg A Reference
       Region 2lzg A 1-125 order
       Region 2lzg A 1-7 high_rmsd
       Region 2lzg A 113-125 high_rmsd
 Evidence X-RAY 3lbl E Reference
       Region 3lbl E 18-18 disorder
       Region 3lbl E 19-41 order
       Region 3lbl E 42-44 disorder
       Region 3lbl E 45-67 order
       Region 3lbl E 68-71 disorder
       Region 3lbl E 72-110 order
       Region 3lbl E 111-111 disorder
 Evidence X-RAY 3lbl C Reference
       Region 3lbl C 18-18 disorder
       Region 3lbl C 19-69 order
       Region 3lbl C 70-70 disorder
       Region 3lbl C 71-110 order
       Region 3lbl C 111-111 disorder
 Evidence X-RAY 3lbl A Reference
       Region 3lbl A 18-110 order
       Region 3lbl A 111-111 disorder
 Evidence X-RAY 3lbk A Reference
       Region 3lbk A 18-25 disorder
       Region 3lbk A 26-110 order
       Region 3lbk A 111-111 disorder
 Evidence X-RAY 5lay F Reference
       Region 5lay F 17-22 disorder
       Region 5lay F 23-92 order
       Region 5lay F 93-94 disorder
       Region 5lay F 95-105 order
       Region 5lay F 106-111 disorder
 Evidence X-RAY 5lay E Reference
       Region 5lay E 17-17 disorder
       Region 5lay E 18-111 order
 Evidence X-RAY 5lay D Reference
       Region 5lay D 17-110 order
       Region 5lay D 111-111 disorder
 Evidence X-RAY 5lay C Reference
       Region 5lay C 17-17 disorder
       Region 5lay C 18-111 order
 Evidence X-RAY 5lay B Reference
       Region 5lay B 17-17 disorder
       Region 5lay B 18-111 order
 Evidence X-RAY 5lay A Reference
       Region 5lay A 17-111 order
 Evidence X-RAY 5lav A Reference
       Region 5lav A 19-111 order
 Evidence X-RAY 3jzk A Reference
       Region 3jzk A 17-17 disorder
       Region 3jzk A 18-110 order
       Region 3jzk A 111-111 disorder
 Evidence X-RAY 4jwr C Reference
       Region 4jwr C 17-18 disorder
       Region 4jwr C 19-68 order
       Region 4jwr C 69-72 disorder
       Region 4jwr C 73-110 order
       Region 4jwr C 111-111 disorder
 Evidence X-RAY 4jwr B Reference
       Region 4jwr B 17-18 disorder
       Region 4jwr B 19-68 order
       Region 4jwr B 69-72 disorder
       Region 4jwr B 73-110 order
       Region 4jwr B 111-111 disorder
 Evidence X-RAY 4jwr A Reference
       Region 4jwr A 17-18 disorder
       Region 4jwr A 19-68 order
       Region 4jwr A 69-72 disorder
       Region 4jwr A 73-110 order
       Region 4jwr A 111-111 disorder
 Evidence X-RAY 4jvr E Reference
       Region 4jvr E 18-18 disorder
       Region 4jvr E 19-42 order
       Region 4jvr E 43-43 disorder
       Region 4jvr E 44-68 order
       Region 4jvr E 69-71 disorder
       Region 4jvr E 72-110 order
       Region 4jvr E 111-111 disorder
 Evidence X-RAY 4jvr C Reference
       Region 4jvr C 18-68 order
       Region 4jvr C 69-72 disorder
       Region 4jvr C 73-110 order
       Region 4jvr C 111-111 disorder
 Evidence X-RAY 4jvr A Reference
       Region 4jvr A 18-68 order
       Region 4jvr A 69-72 disorder
       Region 4jvr A 73-110 order
       Region 4jvr A 111-111 disorder
 Evidence X-RAY 4jve A Reference
       Region 4jve A 18-85 order
       Region 4jve A 86-86 disorder
       Region 4jve A 87-110 order
       Region 4jve A 111-111 disorder
 Evidence X-RAY 4jv9 A Reference
       Region 4jv9 A 18-25 disorder
       Region 4jv9 A 26-110 order
       Region 4jv9 A 111-111 disorder
 Evidence X-RAY 4jv7 A Reference
       Region 4jv7 A 18-25 disorder
       Region 4jv7 A 26-110 order
       Region 4jv7 A 111-111 disorder
 Evidence X-RAY 3iwy C Reference
       Region 3iwy C 25-25 disorder
       Region 3iwy C 26-108 order
       Region 3iwy C 109-109 disorder
 Evidence X-RAY 3iwy A Reference
       Region 3iwy A 25-25 disorder
       Region 3iwy A 26-107 order
       Region 3iwy A 108-109 disorder
 Evidence X-RAY 5hmk B Reference
       Region 5hmk B 17-20 disorder
       Region 5hmk B 21-111 order
       Region 5hmk B 112-125 disorder
 Evidence X-RAY 5hmk A Reference
       Region 5hmk A 17-25 disorder
       Region 5hmk A 26-111 order
       Region 5hmk A 112-125 disorder
 Evidence X-RAY 5hmi B Reference
       Region 5hmi B 18-19 disorder
       Region 5hmi B 20-116 order
 Evidence X-RAY 5hmi A Reference
       Region 5hmi A 18-113 order
       Region 5hmi A 114-116 disorder
 Evidence X-RAY 5hmh B Reference
       Region 5hmh B 21-116 order
 Evidence X-RAY 5hmh A Reference
       Region 5hmh A 21-113 order
       Region 5hmh A 114-116 disorder
 Evidence X-RAY 4hg7 A Reference
       Region 4hg7 A 17-17 disorder
       Region 4hg7 A 18-108 order
 Evidence X-RAY 4hbm H Reference
       Region 4hbm H 6-7 disorder
       Region 4hbm H 8-67 order
       Region 4hbm H 68-72 disorder
       Region 4hbm H 73-111 order
       Region 4hbm H 112-125 disorder
 Evidence X-RAY 4hbm G Reference
       Region 4hbm G 6-6 disorder
       Region 4hbm G 7-67 order
       Region 4hbm G 68-72 disorder
       Region 4hbm G 73-111 order
       Region 4hbm G 112-125 disorder
 Evidence X-RAY 4hbm F Reference
       Region 4hbm F 6-6 disorder
       Region 4hbm F 7-67 order
       Region 4hbm F 68-71 disorder
       Region 4hbm F 72-111 order
       Region 4hbm F 112-125 disorder
 Evidence X-RAY 4hbm E Reference
       Region 4hbm E 6-6 disorder
       Region 4hbm E 7-67 order
       Region 4hbm E 68-71 disorder
       Region 4hbm E 72-111 order
       Region 4hbm E 112-125 disorder
 Evidence X-RAY 4hbm D Reference
       Region 4hbm D 6-6 disorder
       Region 4hbm D 7-67 order
       Region 4hbm D 68-72 disorder
       Region 4hbm D 73-110 order
       Region 4hbm D 111-125 disorder
 Evidence X-RAY 4hbm C Reference
       Region 4hbm C 6-7 disorder
       Region 4hbm C 8-111 order
       Region 4hbm C 112-125 disorder
 Evidence X-RAY 4hbm B Reference
       Region 4hbm B 6-7 disorder
       Region 4hbm B 8-111 order
       Region 4hbm B 112-125 disorder
 Evidence X-RAY 4hbm A Reference
       Region 4hbm A 6-111 order
       Region 4hbm A 112-125 disorder
 Evidence X-RAY 2gv2 A Reference
       Region 2gv2 A 17-24 disorder
       Region 2gv2 A 25-112 order
       Region 2gv2 A 113-125 disorder
 Evidence X-RAY 4erf E Reference
       Region 4erf E 17-17 disorder
       Region 4erf E 18-110 order
       Region 4erf E 111-111 disorder
 Evidence X-RAY 4erf C Reference
       Region 4erf C 17-17 disorder
       Region 4erf C 18-110 order
       Region 4erf C 111-111 disorder
 Evidence X-RAY 4erf A Reference
       Region 4erf A 17-18 disorder
       Region 4erf A 19-110 order
       Region 4erf A 111-111 disorder
 Evidence X-RAY 4ere B Reference
       Region 4ere B 17-67 order
       Region 4ere B 68-72 disorder
       Region 4ere B 73-111 order
 Evidence X-RAY 4ere A Reference
       Region 4ere A 17-21 disorder
       Region 4ere A 22-67 order
       Region 4ere A 68-72 disorder
       Region 4ere A 73-111 order
 Evidence X-RAY 4dij B Reference
       Region 4dij B 17-17 disorder
       Region 4dij B 18-110 order
       Region 4dij B 111-111 disorder
 Evidence X-RAY 4dij A Reference
       Region 4dij A 17-17 disorder
       Region 4dij A 18-110 order
       Region 4dij A 111-111 disorder
 Evidence X-RAY 5c5a B Reference
       Region 5c5a B 20-111 order
 Evidence X-RAY 5c5a A Reference
       Region 5c5a A 20-111 order
Seq 1-125 Homo dimer :
 Evidence X-RAY 3vbg D Reference
       Region 3vbg D 25-109 order
 Evidence X-RAY 3vbg C Reference
       Region 3vbg C 25-25 disorder
       Region 3vbg C 26-109 order
 Evidence X-RAY 3vbg B Reference
       Region 3vbg B 25-109 order
 Evidence X-RAY 3vbg A Reference
       Region 3vbg A 25-25 disorder
       Region 3vbg A 26-109 order
 Evidence X-RAY 4umn B Reference
       Region 4umn B 6-17 disorder
       Region 4umn B 18-110 order
       Region 4umn B 111-125 disorder
 Evidence X-RAY 4umn A Reference
       Region 4umn A 6-17 disorder
       Region 4umn A 18-112 order
       Region 4umn A 113-125 disorder
 Evidence X-RAY 1t4e B Reference
       Region 1t4e B 17-111 order
 Evidence X-RAY 1t4e A Reference
       Region 1t4e A 17-111 order
 Evidence X-RAY 5j7g D Reference
       Region 5j7g D 18-111 order
       Region 5j7g D 112-125 disorder
 Evidence X-RAY 5j7g C Reference
       Region 5j7g C 18-111 order
       Region 5j7g C 112-125 disorder
 Evidence X-RAY 5j7g C Reference
       Region 5j7g C 18-111 order
       Region 5j7g C 112-125 disorder
 Evidence X-RAY 5j7g B Reference
       Region 5j7g B 18-114 order
       Region 5j7g B 115-125 disorder
 Evidence X-RAY 5j7g D Reference
       Region 5j7g D 18-111 order
       Region 5j7g D 112-125 disorder
 Evidence X-RAY 5j7g A Reference
       Region 5j7g A 18-110 order
       Region 5j7g A 111-125 disorder
 Evidence X-RAY 5j7f C Reference
       Region 5j7f C 1-10 disorder
       Region 5j7f C 11-111 order
       Region 5j7f C 112-125 disorder
 Evidence X-RAY 5j7f B Reference
       Region 5j7f B 1-11 disorder
       Region 5j7f B 12-114 order
       Region 5j7f B 115-125 disorder
 Evidence X-RAY 5j7f D Reference
       Region 5j7f D 1-11 disorder
       Region 5j7f D 12-110 order
       Region 5j7f D 111-125 disorder
 Evidence X-RAY 5j7f A Reference
       Region 5j7f A 1-10 disorder
       Region 5j7f A 11-111 order
       Region 5j7f A 112-125 disorder
Seq 1-150 Hetero tetramer :
 Evidence X-RAY 5swk A Reference
       Region 5swk A 1-26 disorder
       Region 5swk A 27-110 order
       Region 5swk A 111-150 disorder
 Evidence X-RAY 5swk B Reference
       Region 5swk B 1-25 disorder
       Region 5swk B 26-110 order
       Region 5swk B 111-150 disorder
Seq 3-109 Hetero dimer : O15350
 Evidence NMR 2mps A Reference
       Region 2mps A 3-109 order
       Region 2mps A 3-24 high_rmsd
Seq 6-125 Hetero dimer :
 Evidence X-RAY 5wts B Reference
       Region 5wts B 6-14 disorder
       Region 5wts B 15-110 order
       Region 5wts B 111-125 disorder
Seq 17-108 Hetero dimer :
 Evidence X-RAY 5afg A Reference
       Region 5afg A 17-25 disorder
       Region 5afg A 26-108 order
Seq 17-125 Hetero dimer :
 Evidence X-RAY 1t4f M Reference
       Region 1t4f M 17-22 disorder
       Region 1t4f M 23-110 order
       Region 1t4f M 111-125 disorder
Seq 17-125 Homo tetramer :
 Evidence X-RAY 4ud7 A Reference
       Region 4ud7 A 17-111 order
       Region 4ud7 A 112-125 disorder
 Evidence X-RAY 4ud7 B Reference
       Region 4ud7 B 17-111 order
       Region 4ud7 B 112-125 disorder
 Evidence X-RAY 4ud7 C Reference
       Region 4ud7 C 17-112 order
       Region 4ud7 C 113-125 disorder
 Evidence X-RAY 4ud7 D Reference
       Region 4ud7 D 17-112 order
       Region 4ud7 D 113-125 disorder
Seq 17-125 Hetero dimer :
 Evidence X-RAY 3jzr A Reference
       Region 3jzr A 17-112 order
       Region 3jzr A 113-125 disorder
Seq 17-125 Hetero dimer :
 Evidence X-RAY 2axi A Reference
       Region 2axi A 17-22 disorder
       Region 2axi A 23-114 order
       Region 2axi A 115-125 disorder
Seq 17-125 Hetero dimer : IID00015Complex
 Evidence X-RAY 1ycr A Reference
       Region 1ycr A 17-24 disorder
       Region 1ycr A 25-109 order
       Region 1ycr A 110-125 disorder
 Evidence X-RAY 4hfz C Reference
       Region 4hfz C 17-108 order
       Region 4hfz C 109-125 disorder
 Evidence X-RAY 4hfz A Reference
       Region 4hfz A 17-25 disorder
       Region 4hfz A 26-108 order
       Region 4hfz A 109-125 disorder
Seq 17-125 Hetero dimer :
 Evidence NMR 2m86 B Reference
       Region 2m86 B 17-26 disorder
       Region 2m86 B 27-109 order
       Region 2m86 B 27-39 high_rmsd
       Region 2m86 B 44-47 high_rmsd
       Region 2m86 B 84-85 high_rmsd
       Region 2m86 B 105-109 high_rmsd
       Region 2m86 B 110-125 disorder
Seq 18-125 Hetero dimer :
 Evidence X-RAY 3g03 A Reference
       Region 3g03 A 18-24 disorder
       Region 3g03 A 25-111 order
       Region 3g03 A 112-125 disorder
Seq 18-125 Hetero dimer :
 Evidence X-RAY 3g03 C Reference
       Region 3g03 C 18-25 disorder
       Region 3g03 C 26-108 order
       Region 3g03 C 109-125 disorder
Seq 24-109 Hetero dimer :
 Evidence X-RAY 3jzs A Reference
       Region 3jzs A 24-25 disorder
       Region 3jzs A 26-108 order
       Region 3jzs A 109-109 disorder
Seq 24-110 Hetero dimer :
 Evidence X-RAY 3v3b A Reference
       Region 3v3b A 24-110 order
Seq 24-110 Hetero dimer :
 Evidence X-RAY 3v3b B Reference
       Region 3v3b B 24-110 order
Seq 25-109 Hetero dimer :
 Evidence X-RAY 5umm C Reference
       Region 5umm C 25-26 disorder
       Region 5umm C 27-108 order
       Region 5umm C 109-109 disorder
Seq 25-109 Hetero hexadecamer :
 Evidence X-RAY 3lnz O Reference
       Region 3lnz O 25-25 disorder
       Region 3lnz O 26-108 order
       Region 3lnz O 109-109 disorder
 Evidence X-RAY 3lnz M Reference
       Region 3lnz M 25-26 disorder
       Region 3lnz M 27-109 order
 Evidence X-RAY 3lnz K Reference
       Region 3lnz K 25-25 disorder
       Region 3lnz K 26-108 order
       Region 3lnz K 109-109 disorder
 Evidence X-RAY 3lnz I Reference
       Region 3lnz I 25-25 disorder
       Region 3lnz I 26-108 order
       Region 3lnz I 109-109 disorder
 Evidence X-RAY 3lnz G Reference
       Region 3lnz G 25-25 disorder
       Region 3lnz G 26-109 order
 Evidence X-RAY 3lnz E Reference
       Region 3lnz E 25-26 disorder
       Region 3lnz E 27-108 order
       Region 3lnz E 109-109 disorder
 Evidence X-RAY 3lnz C Reference
       Region 3lnz C 25-26 disorder
       Region 3lnz C 27-108 order
       Region 3lnz C 109-109 disorder
 Evidence X-RAY 3lnz A Reference
       Region 3lnz A 25-109 order
Seq 25-109 Homo trimer :
 Evidence X-RAY 3lnj E Reference
       Region 3lnj E 25-25 disorder
       Region 3lnj E 26-108 order
       Region 3lnj E 109-109 disorder
 Evidence X-RAY 3lnj C Reference
       Region 3lnj C 25-25 disorder
       Region 3lnj C 26-108 order
       Region 3lnj C 109-109 disorder
 Evidence X-RAY 3lnj A Reference
       Region 3lnj A 25-25 disorder
       Region 3lnj A 26-108 order
       Region 3lnj A 109-109 disorder
Seq 25-109 Hetero dimer :
 Evidence X-RAY 3eqs A Reference
       Region 3eqs A 25-25 disorder
       Region 3eqs A 26-109 order
Seq 25-109 Hetero tetramer :
 Evidence X-RAY 3iux A Reference
       Region 3iux A 25-26 disorder
       Region 3iux A 27-109 order
 Evidence X-RAY 3iux C Reference
       Region 3iux C 25-27 disorder
       Region 3iux C 28-109 order
Seq 25-109 Hetero dimer :
 Evidence X-RAY 5umm A Reference
       Region 5umm A 25-26 disorder
       Region 5umm A 27-108 order
       Region 5umm A 109-109 disorder
Seq 25-109 Homo trimer :
 Evidence X-RAY 1rv1 C Reference
       Region 1rv1 C 25-109 order
 Evidence X-RAY 1rv1 B Reference
       Region 1rv1 B 25-109 order
 Evidence X-RAY 1rv1 A Reference
       Region 1rv1 A 25-109 order
Seq 145-150 Hetero dimer : IID00176Complex
 Evidence X-RAY 2fop B Reference
       Region 2fop B 145-150 order
Seqdisorder 210-304
 Evidence CD¸NMR Reference
       Region 210-304 disorder
       Region 210-275 disorder
Seq 224-232 Monomer : IID00176Complex
 Evidence X-RAY 2f1y A Reference
       Region 2f1y A 224-230 order
       Region 2f1y A 231-232 disorder
Seq 290-335 Monomer :
 Evidence NMR 2c6b A Reference
       Region 2c6b A 290-335 order
       Region 2c6b A 290-295 high_rmsd
       Region 2c6b A 332-335 high_rmsd
 Evidence NMR 2c6a A Reference
       Region 2c6a A 290-335 order
       Region 2c6a A 290-295 high_rmsd
       Region 2c6a A 333-335 high_rmsd
Seq 290-437 Hetero dimer : P62913
 Evidence X-RAY 4xxb B Reference
       Region 4xxb B 290-292 disorder
       Region 4xxb B 293-334 order
       Region 4xxb B 335-437 disorder
Seq 394-403 Hetero dimer : IID00176Complex
 Evidence X-RAY 3mqs D Reference
       Region 3mqs D 394-394 disorder
       Region 3mqs D 395-401 order
       Region 3mqs D 402-403 disorder
Seq 428-491 Hetero tetramer : IID00005Complex
 Evidence X-RAY 2vjf C Reference
       Region 2vjf C 428-491 order
 Evidence X-RAY 2vjf A Reference
       Region 2vjf A 428-491 order
 Evidence X-RAY 2vje C Reference
       Region 2vje C 428-431 disorder
       Region 2vje C 432-491 order
 Evidence X-RAY 2vje A Reference
       Region 2vje A 428-431 disorder
       Region 2vje A 432-491 order
Seq 428-491 Hetero tetramer : IID00005Complex,P0CG47,P62837
 Evidence X-RAY 5mnj G Reference
       Region 5mnj G 428-491 order
 Evidence X-RAY 5mnj C Reference
       Region 5mnj C 428-428 disorder
       Region 5mnj C 429-491 order
Seq 429-491 Homo dimer :
 Evidence NMR 2hdp B Reference
       Region 2hdp B 429-491 order
       Region 2hdp B 429-435 high_rmsd
 Evidence NMR 2hdp A Reference
       Region 2hdp A 429-491 order
       Region 2hdp A 429-435 high_rmsd
SeqProS possible 145-150 This region binds upon the p53 recognition region in USP7. The binding region in p53 (IID00015) to USP7 is shown to be a verified ProS. Hetero dimer : IID00176Complex
       Region 2fop B 145-150 order
SeqProS verified 224-230 This region binds upon the p53 recognition region in USP7. : IID00176Complex
       Region 2f1y A 224-230 order
       Region 210-304 disorder
Seqphosphorylation
    407-407 Phosphoserine; by ATM
    419-419 Phosphothreonine; by ATM
    425-425 Phosphoserine; by ATM
    429-429 Phosphoserine; by ATM
    166-166 Phosphoserine; by SGK1
    190-190 Phosphoserine
    240-240 Phosphoserine
    242-242 Phosphoserine
    246-246 Phosphoserine
    260-260 Phosphoserine
    262-262 Phosphoserine
    386-386 Phosphoserine; by ATM
    395-395 Phosphoserine; by ATM
 
Prediction
NeProc
Disorder 1-21,116-296,336-432
Order 22-115,297-335,433-491
ProS 15-21,143-147,164-213,220-259,272-286,292-296,353-374,390-394,403-415,426-432
AlphaFold
Disorder 1-24,112-246,252-273,278-278,280-294,332-359,361-434,491-491
Order 25-111,247-251,274-277,279-279,295-331,360-360,435-490
Pfam Hmmer
PF02201 27-102 9e-26
PF00641 299-328 5e-09
SEG 30-39 ,202-215 ,252-264 ,394-408
Function
Function in SwissProt
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903).
Biological Process
Diagram with PDB data
MDM2/USP7The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
MDM2NMR structure of unliganded MDM2
MDM2/MDM4Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
See also
Diagram with PDB data
FOXO3/YWHAECrystal Structure of 14-3-3 epsilon with FOXO3a peptide
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex
TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide