Search Keyword:


Search option:


IID00169
 UniprotQ13127
ProteinRE1-silencing transcription factor
GeneREST
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1097
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-83
 Evidence NMR Reference
       Region 1-83 disorder
Seq 43-57 Hetero dimer : IID50092Complex
 Evidence NMR 2czy B Reference
       Region 2czy B 43-57 order
       Region 2czy B 57-57 high_rmsd
Seq 858-869 Hetero tetramer : A0A1S2ZIM2
 Evidence X-RAY 6du2 D Reference
       Region 6du2 D 858-863 order
       Region 6du2 D 864-869 disorder
 Evidence X-RAY 6du2 C Reference
       Region 6du2 C 858-859 disorder
       Region 6du2 C 860-865 order
       Region 6du2 C 866-869 disorder
Seq 858-869 Hetero tetramer : IID00394Complex
 Evidence X-RAY 6du3 D Reference
       Region 6du3 D 858-858 disorder
       Region 6du3 D 859-863 order
       Region 6du3 D 864-869 disorder
 Evidence X-RAY 6du3 C Reference
       Region 6du3 C 858-858 disorder
       Region 6du3 C 859-865 order
       Region 6du3 C 866-869 disorder
SeqProS verified 43-57 Hetero dimer : IID50092Complex
       Region 2czy B 43-57 order
       Region 1-83 disorder
SeqProS predicted 858-865 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero tetramer : A0A1S2ZIM2
       Region 6du2 C 860-865 order
       Region 6du2 D 858-863 order
SeqProS predicted 859-865 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero tetramer : IID00394Complex
       Region 6du3 C 859-865 order
       Region 6du3 D 859-863 order
Seqphosphorylation
    864-864 Phosphoserine
    971-971 Phosphoserine
 
Prediction
NeProc
Disorder 1-28,94-108,121-127,428-477,515-523,529-1055,1094-1097
Order 29-93,109-120,128-427,478-514,524-528,1056-1093
ProS 4-28,94-108,121-127,428-477,515-523,529-606,835-849,1013-1037
AlphaFold
Disorder 1-41,43-43,45-45,47-48,50-51,53-157,183-214,237-237,239-246,253-253,269-274,356-360,385-386,414-827,829-829,837-837,840-1058,1092-1097
Order 42-42,44-44,46-46,49-49,52-52,158-182,215-236,238-238,247-252,254-268,275-355,361-384,387-413,828-828,830-836,838-839,1059-1091
Pfam Hmmer
PF00096 304-326 5.8e-06
SEG 7-23 ,87-96 ,424-432 ,508-522 ,535-555 ,569-598 ,795-804 ,812-823
Function
Function in SwissProt
Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity).
Biological Process
Diagram with PDB data
REST/CTDSP1Structure of Scp1 D96N bound to REST-pS861/4 peptide
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex