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IID00170
 UniprotQ13541
ProteinEukaryotic translation initiation factor 4E-binding protein 1
GeneEIF4EBP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
118
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-118
 Evidence NMR Reference
       Region 1-118 disorder
Seq 43-84 Hetero dimer : IID50218Complex
 Evidence X-RAY 5bxv D Reference
       Region 5bxv D 43-50 disorder
       Region 5bxv D 51-83 order
       Region 5bxv D 84-84 disorder
 Evidence X-RAY 5bxv B Reference
       Region 5bxv B 43-49 disorder
       Region 5bxv B 50-84 order
Seq 47-66 Hetero dimer : IID00341Complex
 Evidence X-RAY 1wkw B Reference
       Region 1wkw B 47-66 order
 Evidence X-RAY 2v8y F Reference
       Region 2v8y F 51-64 order
 Evidence X-RAY 2v8y B Reference
       Region 2v8y B 51-64 order
 Evidence X-RAY 2v8x F Reference
       Region 2v8x F 51-64 order
 Evidence X-RAY 2v8x B Reference
       Region 2v8x B 51-64 order
 Evidence X-RAY 2v8w F Reference
       Region 2v8w F 51-64 order
 Evidence X-RAY 2v8w B Reference
       Region 2v8w B 51-64 order
 Evidence X-RAY 3u7x D Reference
       Region 3u7x D 47-49 disorder
       Region 3u7x D 50-63 order
       Region 3u7x D 64-66 disorder
 Evidence X-RAY 3u7x C Reference
       Region 3u7x C 47-49 disorder
       Region 3u7x C 50-63 order
       Region 3u7x C 64-66 disorder
 Evidence X-RAY 5ekv D Reference
       Region 5ekv D 51-64 order
 Evidence X-RAY 5ekv B Reference
       Region 5ekv B 51-64 order
Seq 50-83 Hetero tetramer : IID00342Complex
 Evidence X-RAY 5nvn D Reference
       Region 5nvn D 50-83 order
 Evidence X-RAY 5nvn B Reference
       Region 5nvn B 50-83 order
Seq 50-83 Hetero dimer : IID00341Complex
 Evidence X-RAY 4ued B Reference
       Region 4ued B 50-83 order
Seq 51-66 Hetero dimer : IID50218Complex
 Evidence X-RAY 1ejh H Reference
       Region 1ejh H 54-64 order
       Region 1ejh H 65-66 disorder
 Evidence X-RAY 1ejh G Reference
       Region 1ejh G 54-63 order
       Region 1ejh G 64-66 disorder
 Evidence X-RAY 1ejh F Reference
       Region 1ejh F 54-66 order
 Evidence X-RAY 1ejh E Reference
       Region 1ejh E 54-65 order
       Region 1ejh E 66-66 disorder
 Evidence X-RAY 1ej4 B Reference
       Region 1ej4 B 51-64 order
Seq 51-67 Hetero dimer :
 Evidence X-RAY 3hxg C Reference
       Region 3hxg C 51-64 order
       Region 3hxg C 65-67 disorder
Seq 51-67 Hetero dimer : IID50113Complex
 Evidence X-RAY 3m94 C Reference
       Region 3m94 C 51-63 order
       Region 3m94 C 64-67 disorder
 Evidence X-RAY 3m93 C Reference
       Region 3m93 C 51-63 order
       Region 3m93 C 64-67 disorder
Seq 51-67 Hetero dimer :
 Evidence X-RAY 3hxi C Reference
       Region 3hxi C 51-63 order
       Region 3hxi C 64-67 disorder
Seq 51-67 Hetero dimer : IID00342Complex
 Evidence X-RAY 2jgc B Reference
       Region 2jgc B 51-66 order
       Region 2jgc B 67-67 disorder
 Evidence X-RAY 2jgb B Reference
       Region 2jgb B 51-66 order
       Region 2jgb B 67-67 disorder
Seq 99-118 Hetero dimer : Q93YQ1
 Evidence X-RAY 5wbj T Reference
       Region 5wbj T 99-110 disorder
       Region 5wbj T 111-118 order
SeqProS verified 47-66 Hetero dimer : IID00342Complex
       Region 2jgc B 51-66 order
       Region 2jgb B 51-66 order
       Region 1-118 disorder
SeqProS verified 47-66 Hetero dimer : IID50113Complex
       Region 3m93 C 51-63 order
       Region 3m94 C 51-63 order
       Region 1-118 disorder
SeqProS verified 47-66 Hetero dimer :
       Region 3hxg C 51-64 order
       Region 1-118 disorder
SeqProS verified 47-66 Hetero dimer :
       Region 3hxi C 51-63 order
       Region 1-118 disorder
SeqProS verified 47-83 Hetero dimer : IID50218Complex
       Region 1ej4 B 51-64 order
       Region 1ejh E 54-65 order
       Region 1ejh F 54-66 order
       Region 1ejh G 54-63 order
       Region 1ejh H 54-64 order
       Region 1-118 disorder
SeqProS verified 47-83 Hetero dimer : IID00341Complex
       Region 2v8x B 51-64 order
       Region 2v8x F 51-64 order
       Region 2v8y B 51-64 order
       Region 2v8y F 51-64 order
       Region 2v8w B 51-64 order
       Region 2v8w F 51-64 order
       Region 1wkw B 47-66 order
       Region 3u7x C 50-63 order
       Region 3u7x D 50-63 order
       Region 5ekv B 51-64 order
       Region 5ekv D 51-64 order
       Region 1-118 disorder
SeqProS verified 50-84 Hetero dimer : IID50218Complex
       Region 5bxv B 50-84 order
       Region 5bxv D 51-83 order
       Region 1-118 disorder
SeqProS verified 50-84 Hetero dimer : IID00341Complex
       Region 4ued B 50-83 order
       Region 1-118 disorder
SeqProS verified 50-84 Hetero tetramer : IID00342Complex
       Region 5nvn B 50-83 order
       Region 5nvn D 50-83 order
       Region 1-118 disorder
SeqProS verified 111-118 Hetero dimer : Q93YQ1
       Region 5wbj T 111-118 order
       Region 1-118 disorder
Seqphosphorylation
    70-70 Phosphothreonine; by MTOR
    112-112 Phosphoserine
    101-101 Phosphoserine; by DYRK2
    96-96 Phosphoserine
    83-83 Phosphoserine
    77-77 Phosphothreonine
    65-65 Phosphoserine; by DYRK2
    54-54 Phosphotyrosine
    50-50 Phosphothreonine
    46-46 Phosphothreonine; by MTOR
    44-44 Phosphoserine
    41-41 Phosphothreonine
    37-37 Phosphothreonine; by MTOR
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-17,85-118
Order 18-84
ProS 12-17,110-118
AlphaFold
Disorder 1-16,23-28,30-31,85-111
Order 17-22,29-29,32-84,112-118
Pfam Hmmer
PF05456 1-118 4.7e-46
Function
Function in SwissProt
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.