Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG437
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 410-427 Hetero trimer : IID00017 Complex
Region 1n4m E 410-421 order
Region 1n4m E 422-427 disorder
Region 1n4m D 410-427 order
Seq 410-427 Hetero dimer : IID00017 Complex
Region 1n4m C 410-427 order
Seq ProS possible 410-427 IID00017 Complex
Region 1n4m D 410-427 order
Region 1n4m E 410-421 order
Seq ProS possible 410-427 IID00017 Complex
Region 1n4m C 410-427 order
Prediction
Function
Function in SwissProt
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Biological Process
Diagram with PDB data E2F2/RB1 Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
See also Diagram with PDB data LT_SV40/RB1 RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN E1A_ADE05/RB1 Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain RB1/E2F1/TFDP1 Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer RB1/PPP1CA Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
Hetero trimer : IID00017Complex
