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IID00171
 UniprotQ14209
ProteinTranscription factor E2F2
GeneE2F2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 410-427 Hetero trimer : IID00017Complex
 Evidence X-RAY 1n4m E Reference
       Region 1n4m E 410-421 order
       Region 1n4m E 422-427 disorder
 Evidence X-RAY 1n4m D Reference
       Region 1n4m D 410-427 order
Seq 410-427 Hetero dimer : IID00017Complex
 Evidence X-RAY 1n4m C Reference
       Region 1n4m C 410-427 order
SeqProS possible 410-427 This region binds to Rb (IID00017). The binding region in Rb has another binding fragment from E1A (IID90003), which is a verfied ProS. Hetero trimer : IID00017Complex
       Region 1n4m D 410-427 order
       Region 1n4m E 410-421 order
SeqProS possible 410-427 This region binds to Rb (IID00017). The binding region in Rb has another binding fragment from E1A (IID90003), which is a verfied ProS. Hetero dimer : IID00017Complex
       Region 1n4m C 410-427 order
 
Prediction
NeProc
Disorder 1-128,307-400
Order 129-306,401-437
ProS 12-28,43-48,60-74,82-94,370-400
AlphaFold
Disorder 1-127,194-204,306-398,400-400,403-416,418-418,423-423,425-437
Order 128-193,205-305,399-399,401-402,417-417,419-422,424-424
Pfam Hmmer
PF02319 129-194 1.1e-36
SEG 39-59 ,205-217 ,309-330 ,343-370
Function
Function in SwissProt
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Biological Process
Diagram with PDB data
E2F2/RB1Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
See also
Diagram with PDB data
LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
E1A_ADE05/RB1Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1