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IID00173
 UniprotQ15648
ProteinMediator of RNA polymerase II transcription subunit 1
GeneMED1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1581
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 640-652 Hetero dimer : IID50032Complex
 Evidence X-RAY 2zfx C Reference
       Region 2zfx C 640-642 disorder
       Region 2zfx C 643-651 order
       Region 2zfx C 652-652 disorder
 Evidence X-RAY 4ynk C Reference
       Region 4ynk C 640-640 disorder
       Region 4ynk C 641-650 order
       Region 4ynk C 651-652 disorder
 Evidence X-RAY 3wtq C Reference
       Region 3wtq C 640-650 order
       Region 3wtq C 651-652 disorder
 Evidence X-RAY 3wt7 C Reference
       Region 3wt7 C 640-650 order
       Region 3wt7 C 651-652 disorder
 Evidence X-RAY 3wt6 C Reference
       Region 3wt6 C 640-650 order
       Region 3wt6 C 651-652 disorder
 Evidence X-RAY 3wt5 C Reference
       Region 3wt5 C 640-650 order
       Region 3wt5 C 651-652 disorder
 Evidence X-RAY 3w5t C Reference
       Region 3w5t C 640-650 order
       Region 3w5t C 651-652 disorder
 Evidence X-RAY 3w5r C Reference
       Region 3w5r C 640-650 order
       Region 3w5r C 651-652 disorder
 Evidence X-RAY 3w5q C Reference
       Region 3w5q C 640-650 order
       Region 3w5q C 651-652 disorder
 Evidence X-RAY 3w5p C Reference
       Region 3w5p C 640-650 order
       Region 3w5p C 651-652 disorder
 Evidence X-RAY 3w0j C Reference
       Region 3w0j C 640-640 disorder
       Region 3w0j C 641-651 order
       Region 3w0j C 652-652 disorder
 Evidence X-RAY 3w0i C Reference
       Region 3w0i C 640-651 order
       Region 3w0i C 652-652 disorder
 Evidence X-RAY 3w0h C Reference
       Region 3w0h C 640-640 disorder
       Region 3w0h C 641-651 order
       Region 3w0h C 652-652 disorder
 Evidence X-RAY 3w0g C Reference
       Region 3w0g C 640-651 order
       Region 3w0g C 652-652 disorder
 Evidence X-RAY 3vrw C Reference
       Region 3vrw C 640-640 disorder
       Region 3vrw C 641-650 order
       Region 3vrw C 651-652 disorder
 Evidence X-RAY 3vrv C Reference
       Region 3vrv C 640-640 disorder
       Region 3vrv C 641-650 order
       Region 3vrv C 651-652 disorder
 Evidence X-RAY 3vru C Reference
       Region 3vru C 640-640 disorder
       Region 3vru C 641-650 order
       Region 3vru C 651-652 disorder
 Evidence X-RAY 3vrt C Reference
       Region 3vrt C 640-640 disorder
       Region 3vrt C 641-650 order
       Region 3vrt C 651-652 disorder
 Evidence X-RAY 3vjt C Reference
       Region 3vjt C 640-640 disorder
       Region 3vjt C 641-650 order
       Region 3vjt C 651-652 disorder
 Evidence X-RAY 3vjs C Reference
       Region 3vjs C 640-640 disorder
       Region 3vjs C 641-650 order
       Region 3vjs C 651-652 disorder
 Evidence X-RAY 1rkh C Reference
       Region 1rkh C 640-650 order
       Region 1rkh C 651-652 disorder
 Evidence X-RAY 1rkg C Reference
       Region 1rkg C 640-640 disorder
       Region 1rkg C 641-651 order
       Region 1rkg C 652-652 disorder
 Evidence X-RAY 1rk3 C Reference
       Region 1rk3 C 640-650 order
       Region 1rk3 C 651-652 disorder
 Evidence X-RAY 1rjk C Reference
       Region 1rjk C 640-650 order
       Region 1rjk C 651-652 disorder
 Evidence X-RAY 2o4r C Reference
       Region 2o4r C 640-650 order
       Region 2o4r C 651-652 disorder
 Evidence X-RAY 2o4j C Reference
       Region 2o4j C 640-651 order
       Region 2o4j C 652-652 disorder
 Evidence X-RAY 5gid C Reference
       Region 5gid C 641-649 order
 Evidence X-RAY 5gic C Reference
       Region 5gic C 641-650 order
 Evidence X-RAY 5b5b F Reference
       Region 5b5b F 640-650 order
       Region 5b5b F 651-652 disorder
 Evidence X-RAY 5b5b C Reference
       Region 5b5b C 640-650 order
       Region 5b5b C 651-652 disorder
 Evidence X-RAY 5b41 C Reference
       Region 5b41 C 640-650 order
       Region 5b41 C 651-652 disorder
 Evidence X-RAY 5awk C Reference
       Region 5awk C 640-650 order
       Region 5awk C 651-652 disorder
 Evidence X-RAY 5awj C Reference
       Region 5awj C 640-650 order
       Region 5awj C 651-652 disorder
 Evidence X-RAY 3aun B Reference
       Region 3aun B 640-642 disorder
       Region 3aun B 643-651 order
       Region 3aun B 652-652 disorder
 Evidence X-RAY 3a2h B Reference
       Region 3a2h B 640-642 disorder
       Region 3a2h B 643-649 order
       Region 3a2h B 650-652 disorder
Seq 641-650 Hetero tetramer : IID50032Complex
 Evidence X-RAY 5gie E Reference
       Region 5gie E 641-650 order
 Evidence X-RAY 5gie C Reference
       Region 5gie C 641-650 order
SeqProS possible 640-650 LXXLL motif Hetero tetramer : IID50032Complex
       Region 5gie C 641-650 order
       Region 5gie E 641-650 order
SeqProS possible 640-651 LXXLL motif Hetero dimer : IID50032Complex
       Region 2zfx C 643-651 order
       Region 1rkh C 640-650 order
       Region 2o4r C 640-650 order
       Region 1rk3 C 640-650 order
       Region 1rkg C 641-651 order
       Region 2o4j C 640-651 order
       Region 1rjk C 640-650 order
       Region 3a2h B 643-649 order
       Region 3w5q C 640-650 order
       Region 3vjt C 641-650 order
       Region 3vjs C 641-650 order
       Region 3aun B 643-651 order
       Region 3vrt C 641-650 order
       Region 3w5r C 640-650 order
       Region 3w5t C 640-650 order
       Region 3vru C 641-650 order
       Region 3w5p C 640-650 order
       Region 3vrw C 641-650 order
       Region 3vrv C 641-650 order
       Region 3wt6 C 640-650 order
       Region 3w0j C 641-651 order
       Region 3wt5 C 640-650 order
       Region 3w0g C 640-651 order
       Region 3w0h C 641-651 order
       Region 3w0i C 640-651 order
       Region 3wt7 C 640-650 order
       Region 3wtq C 640-650 order
       Region 5awj C 640-650 order
       Region 5gid C 641-649 order
       Region 5awk C 640-650 order
       Region 5b41 C 640-650 order
       Region 5b5b C 640-650 order
       Region 5b5b F 640-650 order
       Region 5gic C 641-650 order
       Region 4ynk C 641-650 order
Seqphosphorylation
    588-588 Phosphoserine
    664-664 Phosphoserine
    795-795 Phosphoserine
    805-805 Phosphothreonine
    887-887 Phosphoserine
    953-953 Phosphoserine
    1032-1032 Phosphothreonine; by MAPK1 or MAPK3
    1051-1051 Phosphothreonine
    1057-1057 Phosphothreonine
    1156-1156 Phosphoserine
    1207-1207 Phosphoserine
    1215-1215 Phosphothreonine
    1223-1223 Phosphoserine
    1302-1302 Phosphoserine
    1347-1347 Phosphoserine
    1403-1403 Phosphoserine
    1433-1433 Phosphoserine
    1440-1440 Phosphothreonine
    1457-1457 Phosphothreonine; by MAPK1 or MAPK3
    1463-1463 Phosphoserine
    1465-1465 Phosphoserine
    1479-1479 Phosphoserine
    1481-1481 Phosphoserine
    1482-1482 Phosphoserine
Seqacetylation
    1177-1177 N6-acetyllysine
    1529-1529 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-16,243-246,519-1573
Order 17-236,247-347,357-518,1574-1581
ProS 243-246,706-709,890-893,1305-1309,1562-1573
AlphaFold
Disorder 1-10,26-31,33-33,43-56,58-58,63-63,66-72,233-239,241-241,243-247,249-249,276-285,352-359,431-433,484-484,521-530,534-535,537-1581
Order 11-25,32-32,34-42,57-57,59-62,64-65,73-232,240-240,242-242,248-248,250-275,286-351,360-430,434-483,485-520,531-533,536-536
SEG 8-23 ,551-574 ,610-634 ,682-693 ,747-764 ,843-854 ,1004-1014 ,1032-1045 ,1057-1069 ,1078-1156 ,1218-1256 ,1262-1294 ,1353-1382 ,1495-1524
Function
Function in SwissProt
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).