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IID00175
 UniprotQ16633
ProteinPOU domain class 2-associating factor 1
GenePOU2AF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
256
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-44 Hetero dimer : IID00144Complex
 Evidence X-RAY 1cqt J Reference
       Region 1cqt J 1-15 disorder
       Region 1cqt J 16-38 order
       Region 1cqt J 39-44 disorder
 Evidence X-RAY 1cqt I Reference
       Region 1cqt I 1-15 disorder
       Region 1cqt I 16-37 order
       Region 1cqt I 38-44 disorder
Seqdisorder 1-65
 Evidence CD Reference
       Region 1-65 disorder
Seqdisorder 1-256
 Evidence CD¸ SAXS¸ NMR Reference
       Region 1-256 disorder
SeqProS verified 16-38 Hetero dimer : IID00144Complex
       Region 1cqt I 16-37 order
       Region 1cqt J 16-38 order
       Region 1-65 disorder
 
Prediction
NeProc
Disorder 1-16,24-256
Order 17-23
ProS 1-4,24-40,50-56,80-89,96-110,119-151,163-189,202-211,229-256
AlphaFold
Disorder 1-12,37-120,137-177,179-230,238-256
Order 13-36,121-136,178-178,231-237
Function
Function in SwissProt
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).
Biological Process
Diagram with PDB data
POU2AF1/POU2F1/DNACRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT