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IID00176
 UniprotQ93009
ProteinUbiquitin carboxyl-terminal hydrolase 7
GeneUSP7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1102
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 43-560 Monomer :
 Evidence X-RAY 2f1z B Reference
       Region 2f1z B 43-62 disorder
       Region 2f1z B 63-499 order
       Region 2f1z B 500-509 disorder
       Region 2f1z B 510-553 order
       Region 2f1z B 554-560 disorder
 Evidence X-RAY 2f1z A Reference
       Region 2f1z A 43-63 disorder
       Region 2f1z A 64-104 order
       Region 2f1z A 105-112 disorder
       Region 2f1z A 113-219 order
       Region 2f1z A 220-221 disorder
       Region 2f1z A 222-501 order
       Region 2f1z A 502-509 disorder
       Region 2f1z A 510-551 order
       Region 2f1z A 552-560 disorder
Seq 53-198 Monomer : IID00163Complex
 Evidence X-RAY 2f1y A Reference
       Region 2f1y A 53-62 disorder
       Region 2f1y A 63-105 order
       Region 2f1y A 106-112 disorder
       Region 2f1y A 113-198 order
Seq 53-200 Monomer : IID00015Complex
 Evidence X-RAY 2f1x A Reference
       Region 2f1x A 53-62 disorder
       Region 2f1x A 63-105 order
       Region 2f1x A 106-110 disorder
       Region 2f1x A 111-200 order
Seq 53-200 Monomer : IID00015Complex
 Evidence X-RAY 2f1x B Reference
       Region 2f1x B 53-62 disorder
       Region 2f1x B 63-200 order
Seq 53-206 Monomer :
 Evidence X-RAY 1yze C Reference
       Region 1yze C 54-66 disorder
       Region 1yze C 67-74 order
       Region 1yze C 75-84 disorder
       Region 1yze C 85-102 order
       Region 1yze C 103-114 disorder
       Region 1yze C 115-142 order
       Region 1yze C 143-149 disorder
       Region 1yze C 150-176 order
       Region 1yze C 177-187 disorder
       Region 1yze C 188-204 order
       Region 1yze C 205-205 disorder
 Evidence X-RAY 1yze B Reference
       Region 1yze B 54-66 disorder
       Region 1yze B 67-78 order
       Region 1yze B 79-84 disorder
       Region 1yze B 85-104 order
       Region 1yze B 105-114 disorder
       Region 1yze B 115-125 order
       Region 1yze B 126-128 disorder
       Region 1yze B 129-142 order
       Region 1yze B 143-149 disorder
       Region 1yze B 150-175 order
       Region 1yze B 176-188 disorder
       Region 1yze B 189-204 order
       Region 1yze B 205-205 disorder
 Evidence X-RAY 1yze A Reference
       Region 1yze A 54-64 disorder
       Region 1yze A 65-78 order
       Region 1yze A 79-84 disorder
       Region 1yze A 85-104 order
       Region 1yze A 105-114 disorder
       Region 1yze A 115-141 order
       Region 1yze A 142-149 disorder
       Region 1yze A 150-173 order
       Region 1yze A 174-187 disorder
       Region 1yze A 188-203 order
       Region 1yze A 204-205 disorder
 Evidence X-RAY 2f1w A Reference
       Region 2f1w A 53-62 disorder
       Region 2f1w A 63-206 order
Seq 54-204 Hetero dimer : IID90004Complex
 Evidence X-RAY 1yy6 A Reference
       Region 1yy6 A 54-62 disorder
       Region 1yy6 A 63-105 order
       Region 1yy6 A 106-111 disorder
       Region 1yy6 A 112-204 order
Seq 54-205 Hetero dimer : IID00005Complex
 Evidence X-RAY 3mqr A Reference
       Region 3mqr A 54-62 disorder
       Region 3mqr A 63-105 order
       Region 3mqr A 106-111 disorder
       Region 3mqr A 112-205 order
Seq 54-205 Hetero dimer : IID00633Complex
 Evidence X-RAY 4jjq A Reference
       Region 4jjq A 54-62 disorder
       Region 4jjq A 63-105 order
       Region 4jjq A 106-111 disorder
       Region 4jjq A 112-205 order
Seq 54-205 Hetero dimer : IID00163Complex
 Evidence X-RAY 2fop A Reference
       Region 2fop A 54-62 disorder
       Region 2fop A 63-105 order
       Region 2fop A 106-111 disorder
       Region 2fop A 112-205 order
Seq 54-205 Hetero dimer : Q9BTE3
 Evidence X-RAY 4kg9 A Reference
       Region 4kg9 A 54-62 disorder
       Region 4kg9 A 63-106 order
       Region 4kg9 A 107-111 disorder
       Region 4kg9 A 112-205 order
Seq 54-205 Hetero dimer : IID00015Complex
 Evidence X-RAY 2foj A Reference
       Region 2foj A 54-62 disorder
       Region 2foj A 63-105 order
       Region 2foj A 106-111 disorder
       Region 2foj A 112-205 order
Seq 54-205 Hetero dimer : IID00163Complex
 Evidence X-RAY 3mqs C Reference
       Region 3mqs C 54-62 disorder
       Region 3mqs C 63-105 order
       Region 3mqs C 106-111 disorder
       Region 3mqs C 112-205 order
Seq 54-205 Hetero dimer : IID00015Complex
 Evidence X-RAY 2foo A Reference
       Region 2foo A 54-62 disorder
       Region 2foo A 63-105 order
       Region 2foo A 106-111 disorder
       Region 2foo A 112-205 order
Seq 63-205 Hetero dimer : Q2HR73
 Evidence X-RAY 2xxn A Reference
       Region 2xxn A 63-205 order
Seq 63-205 Hetero dimer : F5HF68
 Evidence X-RAY 4ysi A Reference
       Region 4ysi A 63-106 order
       Region 4ysi A 107-111 disorder
       Region 4ysi A 112-205 order
Seq 207-560 Monomer :
 Evidence X-RAY 5whc B Reference
       Region 5whc B 209-500 order
       Region 5whc B 501-508 disorder
       Region 5whc B 509-554 order
 Evidence X-RAY 5whc A Reference
       Region 5whc A 209-500 order
       Region 5whc A 501-508 disorder
       Region 5whc A 509-554 order
 Evidence X-RAY 5vsk B Reference
       Region 5vsk B 208-249 order
       Region 5vsk B 250-255 disorder
       Region 5vsk B 256-332 order
       Region 5vsk B 333-337 disorder
       Region 5vsk B 338-342 order
       Region 5vsk B 343-345 disorder
       Region 5vsk B 346-372 order
       Region 5vsk B 373-389 disorder
       Region 5vsk B 390-500 order
       Region 5vsk B 501-508 disorder
       Region 5vsk B 509-551 order
       Region 5vsk B 552-560 disorder
 Evidence X-RAY 5vsk A Reference
       Region 5vsk A 208-410 order
       Region 5vsk A 411-417 disorder
       Region 5vsk A 418-500 order
       Region 5vsk A 501-508 disorder
       Region 5vsk A 509-552 order
       Region 5vsk A 553-560 disorder
 Evidence X-RAY 5uqx B Reference
       Region 5uqx B 208-410 order
       Region 5uqx B 411-418 disorder
       Region 5uqx B 419-500 order
       Region 5uqx B 501-508 disorder
       Region 5uqx B 509-555 order
 Evidence X-RAY 5uqx A Reference
       Region 5uqx A 208-208 disorder
       Region 5uqx A 209-554 order
       Region 5uqx A 555-555 disorder
 Evidence X-RAY 5uqv B Reference
       Region 5uqv B 208-209 disorder
       Region 5uqv B 210-410 order
       Region 5uqv B 411-418 disorder
       Region 5uqv B 419-501 order
       Region 5uqv B 502-508 disorder
       Region 5uqv B 509-553 order
       Region 5uqv B 554-554 disorder
 Evidence X-RAY 5uqv A Reference
       Region 5uqv A 208-209 disorder
       Region 5uqv A 210-410 order
       Region 5uqv A 411-418 disorder
       Region 5uqv A 419-501 order
       Region 5uqv A 502-508 disorder
       Region 5uqv A 509-553 order
       Region 5uqv A 554-554 disorder
 Evidence X-RAY 5ngf B Reference
       Region 5ngf B 208-208 disorder
       Region 5ngf B 209-411 order
       Region 5ngf B 412-417 disorder
       Region 5ngf B 418-500 order
       Region 5ngf B 501-508 disorder
       Region 5ngf B 509-554 order
       Region 5ngf B 555-560 disorder
 Evidence X-RAY 5ngf A Reference
       Region 5ngf A 208-208 disorder
       Region 5ngf A 209-411 order
       Region 5ngf A 412-417 disorder
       Region 5ngf A 418-500 order
       Region 5ngf A 501-508 disorder
       Region 5ngf A 509-554 order
       Region 5ngf A 555-560 disorder
 Evidence X-RAY 5nge B Reference
       Region 5nge B 208-209 disorder
       Region 5nge B 210-331 order
       Region 5nge B 332-340 disorder
       Region 5nge B 341-371 order
       Region 5nge B 372-390 disorder
       Region 5nge B 391-501 order
       Region 5nge B 502-505 disorder
       Region 5nge B 506-554 order
       Region 5nge B 555-560 disorder
 Evidence X-RAY 5nge A Reference
       Region 5nge A 208-211 disorder
       Region 5nge A 212-501 order
       Region 5nge A 502-509 disorder
       Region 5nge A 510-556 order
       Region 5nge A 557-560 disorder
 Evidence X-RAY 1nb8 B Reference
       Region 1nb8 B 208-410 order
       Region 1nb8 B 411-418 disorder
       Region 1nb8 B 419-501 order
       Region 1nb8 B 502-508 disorder
       Region 1nb8 B 509-555 order
       Region 1nb8 B 556-560 disorder
 Evidence X-RAY 1nb8 A Reference
       Region 1nb8 A 208-410 order
       Region 1nb8 A 411-418 disorder
       Region 1nb8 A 419-501 order
       Region 1nb8 A 502-508 disorder
       Region 1nb8 A 509-554 order
       Region 1nb8 A 555-560 disorder
 Evidence X-RAY 5n9r B Reference
       Region 5n9r B 207-552 order
       Region 5n9r B 553-560 disorder
 Evidence X-RAY 5n9r A Reference
       Region 5n9r A 207-502 order
       Region 5n9r A 503-503 disorder
       Region 5n9r A 504-560 order
 Evidence X-RAY 4m5x B Reference
       Region 4m5x B 207-207 disorder
       Region 4m5x B 208-412 order
       Region 4m5x B 413-415 disorder
       Region 4m5x B 416-501 order
       Region 4m5x B 502-508 disorder
       Region 4m5x B 509-554 order
       Region 4m5x B 555-560 disorder
 Evidence X-RAY 4m5x A Reference
       Region 4m5x A 207-208 disorder
       Region 4m5x A 209-501 order
       Region 4m5x A 502-508 disorder
       Region 4m5x A 509-554 order
       Region 4m5x A 555-560 disorder
 Evidence X-RAY 4m5w A Reference
       Region 4m5w A 207-207 disorder
       Region 4m5w A 208-504 order
       Region 4m5w A 505-508 disorder
       Region 4m5w A 509-554 order
       Region 4m5w A 555-560 disorder
 Evidence X-RAY 5kyb B Reference
       Region 5kyb B 208-208 disorder
       Region 5kyb B 209-411 order
       Region 5kyb B 412-417 disorder
       Region 5kyb B 418-501 order
       Region 5kyb B 502-508 disorder
       Region 5kyb B 509-553 order
       Region 5kyb B 554-554 disorder
 Evidence X-RAY 5kyb A Reference
       Region 5kyb A 208-210 disorder
       Region 5kyb A 211-411 order
       Region 5kyb A 412-417 disorder
       Region 5kyb A 418-501 order
       Region 5kyb A 502-508 disorder
       Region 5kyb A 509-553 order
       Region 5kyb A 554-554 disorder
Seq 207-560 Homo dimer :
 Evidence X-RAY 5n9t B Reference
       Region 5n9t B 207-551 order
       Region 5n9t B 552-560 disorder
 Evidence X-RAY 5n9t A Reference
       Region 5n9t A 207-560 order
 Evidence X-RAY 5vsb B Reference
       Region 5vsb B 208-501 order
       Region 5vsb B 502-508 disorder
       Region 5vsb B 509-548 order
       Region 5vsb B 549-560 disorder
 Evidence X-RAY 5vsb A Reference
       Region 5vsb A 208-210 disorder
       Region 5vsb A 211-500 order
       Region 5vsb A 501-509 disorder
       Region 5vsb A 510-554 order
       Region 5vsb A 555-560 disorder
 Evidence X-RAY 5vs6 B Reference
       Region 5vs6 B 208-208 disorder
       Region 5vs6 B 209-500 order
       Region 5vs6 B 501-509 disorder
       Region 5vs6 B 510-554 order
       Region 5vs6 B 555-560 disorder
 Evidence X-RAY 5vs6 A Reference
       Region 5vs6 A 208-500 order
       Region 5vs6 A 501-508 disorder
       Region 5vs6 A 509-554 order
       Region 5vs6 A 555-560 disorder
Seq 207-882 Monomer :
 Evidence X-RAY 5fwi C Reference
       Region 5fwi C 207-209 disorder
       Region 5fwi C 210-458 order
       Region 5fwi C 459-460 disorder
       Region 5fwi C 461-501 order
       Region 5fwi C 502-509 disorder
       Region 5fwi C 510-881 order
       Region 5fwi C 882-882 disorder
 Evidence X-RAY 5j7t A Reference
       Region 5j7t A 211-881 order
Seq 207-554,882-1102 Hetero dimer : P0CG47
 Evidence X-RAY 5jtv G Reference
       Region 5jtv G 207-208 disorder
       Region 5jtv G 209-554 order
       Region 5jtv G 882-883 disorder
       Region 5jtv G 884-1091 order
       Region 5jtv G 1092-1093 disorder
       Region 5jtv G 1094-1102 order
Seq 207-554,882-1102 Hetero dimer : P0CG47
 Evidence X-RAY 5jtv A Reference
       Region 5jtv A 207-208 disorder
       Region 5jtv A 209-554 order
       Region 5jtv A 882-884 disorder
       Region 5jtv A 885-1102 order
Seq 207-554,882-1102 Hetero dimer : P0CG47
 Evidence X-RAY 5jtv E Reference
       Region 5jtv E 207-208 disorder
       Region 5jtv E 209-554 order
       Region 5jtv E 882-883 disorder
       Region 5jtv E 884-1102 order
Seq 207-554,882-1102 Hetero dimer : P0CG47
 Evidence X-RAY 5jtv C Reference
       Region 5jtv C 207-208 disorder
       Region 5jtv C 209-554 order
       Region 5jtv C 882-884 disorder
       Region 5jtv C 885-1102 order
Seq 208-554 Hetero dimer : P0CG47
 Evidence X-RAY 5kyf B Reference
       Region 5kyf B 208-502 order
       Region 5kyf B 503-506 disorder
       Region 5kyf B 507-551 order
       Region 5kyf B 552-554 disorder
 Evidence X-RAY 5kyd A Reference
       Region 5kyd A 208-209 disorder
       Region 5kyd A 210-550 order
       Region 5kyd A 551-554 disorder
 Evidence X-RAY 5kyc B Reference
       Region 5kyc B 208-209 disorder
       Region 5kyc B 210-549 order
       Region 5kyc B 550-554 disorder
Seq 208-554 Hetero tetramer : P0CG47
 Evidence X-RAY 5kye B Reference
       Region 5kye B 208-210 disorder
       Region 5kye B 211-413 order
       Region 5kye B 414-415 disorder
       Region 5kye B 416-500 order
       Region 5kye B 501-507 disorder
       Region 5kye B 508-549 order
       Region 5kye B 550-554 disorder
 Evidence X-RAY 5kye A Reference
       Region 5kye A 208-208 disorder
       Region 5kye A 209-505 order
       Region 5kye A 506-507 disorder
       Region 5kye A 508-553 order
       Region 5kye A 554-554 disorder
Seq 208-560 Hetero pentamer : P0CG48
 Evidence X-RAY 1nbf E Reference
       Region 1nbf E 208-410 order
       Region 1nbf E 411-417 disorder
       Region 1nbf E 418-554 order
       Region 1nbf E 555-560 disorder
 Evidence X-RAY 1nbf B Reference
       Region 1nbf B 208-554 order
       Region 1nbf B 555-560 disorder
 Evidence X-RAY 1nbf A Reference
       Region 1nbf A 208-554 order
       Region 1nbf A 555-560 disorder
Seq 209-554,1084-1102 Hetero dimer : P0CG47
 Evidence X-RAY 5jtj A Reference
       Region 5jtj A 209-554 order
       Region 5jtj A 1084-1092 disorder
       Region 5jtj A 1093-1102 order
Seq 535-888 Hetero dimer : P08393
 Evidence X-RAY 4wpi B Reference
       Region 4wpi B 535-537 disorder
       Region 4wpi B 538-636 order
       Region 4wpi B 637-641 disorder
       Region 4wpi B 642-882 order
       Region 4wpi B 883-888 disorder
 Evidence X-RAY 4wpi A Reference
       Region 4wpi A 535-542 disorder
       Region 4wpi A 543-883 order
       Region 4wpi A 884-888 disorder
 Evidence X-RAY 4wph B Reference
       Region 4wph B 535-542 disorder
       Region 4wph B 543-638 order
       Region 4wph B 639-645 disorder
       Region 4wph B 646-801 order
       Region 4wph B 802-805 disorder
       Region 4wph B 806-843 order
       Region 4wph B 844-845 disorder
       Region 4wph B 846-881 order
       Region 4wph B 882-888 disorder
 Evidence X-RAY 4wph A Reference
       Region 4wph A 535-539 disorder
       Region 4wph A 540-638 order
       Region 4wph A 639-645 disorder
       Region 4wph A 646-843 order
       Region 4wph A 844-845 disorder
       Region 4wph A 846-885 order
       Region 4wph A 886-888 disorder
Seq 537-664 Monomer :
 Evidence NMR 2kvr A Reference
       Region 2kvr A 537-664 order
       Region 2kvr A 575-582 high_rmsd
       Region 2kvr A 630-632 high_rmsd
Seq 537-793 Homo dimer :
 Evidence X-RAY 4pyz A Reference
       Region 4pyz A 537-793 order
 Evidence X-RAY 4pyz B Reference
       Region 4pyz B 537-793 order
Seq 560-890 Hetero tetramer : Q8NCN4
 Evidence X-RAY 5gg4 D Reference
       Region 5gg4 D 560-561 disorder
       Region 5gg4 D 562-667 order
       Region 5gg4 D 668-673 disorder
       Region 5gg4 D 674-795 order
       Region 5gg4 D 796-890 disorder
 Evidence X-RAY 5gg4 C Reference
       Region 5gg4 C 560-561 disorder
       Region 5gg4 C 562-669 order
       Region 5gg4 C 670-673 disorder
       Region 5gg4 C 674-796 order
       Region 5gg4 C 797-890 disorder
 Evidence X-RAY 5gg4 B Reference
       Region 5gg4 B 560-561 disorder
       Region 5gg4 B 562-667 order
       Region 5gg4 B 668-673 disorder
       Region 5gg4 B 674-680 order
       Region 5gg4 B 681-681 disorder
       Region 5gg4 B 682-885 order
       Region 5gg4 B 886-890 disorder
 Evidence X-RAY 5gg4 A Reference
       Region 5gg4 A 560-561 disorder
       Region 5gg4 A 562-667 order
       Region 5gg4 A 668-674 disorder
       Region 5gg4 A 675-881 order
       Region 5gg4 A 882-890 disorder
Seq 560-1083 Hetero dimer : P26358
 Evidence X-RAY 4z97 A Reference
       Region 4z97 A 560-983 order
       Region 4z97 A 984-984 disorder
       Region 4z97 A 985-1011 order
       Region 4z97 A 1012-1013 disorder
       Region 4z97 A 1014-1031 order
       Region 4z97 A 1032-1034 disorder
       Region 4z97 A 1035-1057 order
       Region 4z97 A 1058-1058 disorder
       Region 4z97 A 1059-1068 order
       Region 4z97 A 1069-1069 disorder
       Region 4z97 A 1070-1083 order
 Evidence X-RAY 4z96 A Reference
       Region 4z96 A 560-983 order
       Region 4z96 A 984-985 disorder
       Region 4z96 A 986-1011 order
       Region 4z96 A 1012-1012 disorder
       Region 4z96 A 1013-1032 order
       Region 4z96 A 1033-1033 disorder
       Region 4z96 A 1034-1057 order
       Region 4z96 A 1058-1058 disorder
       Region 4z96 A 1059-1068 order
       Region 4z96 A 1069-1069 disorder
       Region 4z96 A 1070-1083 order
Seq 560-1084 Monomer :
 Evidence X-RAY 2ylm A Reference
       Region 2ylm A 560-1083 order
       Region 2ylm A 1084-1084 disorder
Seq 560-1102 Hetero dimer : P08393
 Evidence X-RAY 5c56 A Reference
       Region 5c56 A 560-1083 order
       Region 5c56 A 1084-1102 disorder
Seq 560-1102 Hetero dimer : P26358
 Evidence X-RAY 4yoc C Reference
       Region 4yoc C 560-1083 order
       Region 4yoc C 1084-1102 disorder
Seq 561-881 Hetero dimer : IID00327Complex
 Evidence X-RAY 5c6d B Reference
       Region 5c6d B 561-638 order
       Region 5c6d B 639-642 disorder
       Region 5c6d B 643-843 order
       Region 5c6d B 844-847 disorder
       Region 5c6d B 848-870 order
       Region 5c6d B 871-871 disorder
       Region 5c6d B 872-881 order
 Evidence X-RAY 5c6d A Reference
       Region 5c6d A 561-638 order
       Region 5c6d A 639-641 disorder
       Region 5c6d A 642-667 order
       Region 5c6d A 668-674 disorder
       Region 5c6d A 675-881 order
Seqphosphorylation
    18-18 Phosphoserine
    49-49 Phosphoserine
    963-963 Phosphoserine
Seqacetylation
    869-869 N6-acetyllysine; alternate
    1084-1084 N6-acetyllysine
    1096-1096 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-62,1087-1102
Order 63-247,255-504,510-1086
ProS 12-19,1090-1102
AlphaFold
Disorder 1-63,65-65,286-293,461-461,501-509,844-844,963-966,1067-1072,1085-1102
Order 64-64,66-285,294-460,462-500,510-843,845-962,967-1066,1073-1084
Pfam Hmmer
PF00917 75-197 1.9e-30
PF00443 211-518 2.6e-90
SEG 4-10 ,338-349
Function
Function in SwissProt
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:26678539, PubMed:28655758). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758).
(Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Biological Process
See also
Diagram with PDB data
MDM4/USP7Crystal Structure of the USP7:HdmX(AHSS) complex
MDM2/USP7The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
UHRF1/USP7Crystal structure of USP7 in complex with UHRF1