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IID00180
 UniprotQ9BSI4
ProteinTERF1-interacting nuclear factor 2
GeneTINF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
451
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-202 Hetero trimer : Q15554,Q96AP0
 Evidence X-RAY 5xyf A Reference
       Region 5xyf A 2-4 disorder
       Region 5xyf A 5-91 order
       Region 5xyf A 92-94 disorder
       Region 5xyf A 95-199 order
       Region 5xyf A 200-202 disorder
Seq 257-276 Hetero tetramer : IID00155Complex
 Evidence X-RAY 3bqo B Reference
       Region 3bqo B 257-268 order
       Region 3bqo B 269-276 disorder
Seq 258-275 Hetero dimer : Q15554
 Evidence X-RAY 3bu8 C Reference
       Region 3bu8 C 258-271 order
       Region 3bu8 C 272-275 disorder
 Evidence X-RAY 3bu8 D Reference
       Region 3bu8 D 258-266 order
       Region 3bu8 D 267-275 disorder
Seq 258-275 Hetero octamer : Q15554
 Evidence X-RAY 3bu8 C Reference
       Region 3bu8 C 258-271 order
       Region 3bu8 C 272-275 disorder
 Evidence X-RAY 3bu8 D Reference
       Region 3bu8 D 258-266 order
       Region 3bu8 D 267-275 disorder
Seqphosphorylation
    295-295 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-4,178-410,431-451
Order 5-177,411-430
ProS 185-201,207-210,253-266,270-321,334-338,354-377,379-396,405-410,439-451
AlphaFold
Disorder 1-6,90-97,200-451
Order 7-89,98-199
SEG 7-18 ,363-376
Function
Function in SwissProt
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.