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IID00181
 UniprotQ9BX63
ProteinFanconi anemia group J protein
GeneBRIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1249
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 985-998 Hetero dimer : IID00042Complex
 Evidence X-RAY 1t15 B Reference
       Region 1t15 B 988-995 order
 Evidence X-RAY 1t29 B Reference
       Region 1t29 B 985-996 order
       Region 1t29 B 997-998 disorder
Seq 1129-1138 Hetero dimer : Q92547
 Evidence X-RAY 3al3 B Reference
       Region 3al3 B 1129-1138 order
SeqProS predicted 988-995 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : IID00042Complex
       Region 1t29 B 985-996 order
       Region 1t15 B 988-995 order
SeqProS predicted 1129-1138 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : Q92547
       Region 3al3 B 1129-1138 order
Seqphosphorylation
    505-505 Phosphoserine
    927-927 Phosphoserine
    930-930 Phosphoserine
    956-956 Phosphoserine
    990-990 Phosphoserine
    1004-1004 Phosphoserine
    1032-1032 Phosphoserine
    1237-1237 Phosphoserine
Seqacetylation
    1249-1249 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,62-141,162-240,893-1200,1208-1249
Order 6-61,142-161,241-519,524-576,584-892,1201-1207
ProS 62-80,85-141,162-223,941-945,967-974,992-1020,1027-1030,1046-1056,1069-1079,1094-1100,1108-1112,1118-1139,1146-1173,1185-1200,1208-1249
AlphaFold
Disorder 1-3,69-241,305-306,460-462,503-513,559-581,729-733,768-768,890-1249
Order 4-68,242-304,307-459,463-502,514-558,582-728,734-767,769-889
Pfam Hmmer
PF06733 248-415 1e-82
SEG 131-145
Function
Function in SwissProt
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Biological Process
Diagram with PDB data
BRIP1/BRCA1Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase