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IID00183
 UniprotQ9Y6J0
ProteinCalcineurin-binding protein cabin-1
GeneCABIN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2220
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2156-2190 Hetero trimer : Q02080
 Evidence X-RAY 1n6j G Reference
       Region 1n6j G 2156-2158 disorder
       Region 1n6j G 2159-2184 order
       Region 1n6j G 2185-2190 disorder
Seqphosphorylation
    2154-2154 Phosphothreonine
    10-10 Phosphoserine
    11-11 Phosphoserine
    12-12 Phosphothreonine
    2151-2151 Phosphothreonine
    2094-2094 Phosphoserine
    1924-1924 Phosphothreonine
    1439-1439 Phosphoserine
    673-673 Phosphoserine
    450-450 Phosphoserine
    433-433 Phosphoserine
    66-66 Phosphoserine
    20-20 Phosphoserine
 
Prediction
NeProc
Disorder 10-25,73-79,301-407,414-464,566-581,653-658,871-883,1299-1499,1671-2220
Order 1-9,26-72,80-300,408-413,465-565,582-652,659-774,780-808,815-838,845-870,884-1298,1500-1670
ProS 301-305,378-386,396-402,414-424,434-447,566-581,871-879,1299-1310,1341-1374,1863-1867,1935-1939,2214-2220
AlphaFold
Disorder 1-27,73-80,251-256,289-290,306-407,424-465,560-586,629-629,652-661,689-694,717-735,802-803,809-812,833-840,868-884,927-932,957-959,1019-1023,1047-1049,1108-1115,1198-1203,1250-1251,1278-1281,1306-1496,1578-1578,1583-1583,1585-1597,1634-1637,1643-1643,1669-1853,1873-1875,1916-2220
Order 28-72,81-250,257-288,291-305,408-423,466-559,587-628,630-651,662-688,695-716,736-801,804-808,813-832,841-867,885-926,933-956,960-1018,1024-1046,1050-1107,1116-1197,1204-1249,1252-1277,1282-1305,1497-1577,1579-1582,1584-1584,1598-1633,1638-1642,1644-1668,1854-1872,1876-1915
SEG 364-382 ,740-750 ,1327-1349 ,1806-1834 ,1840-1850 ,1940-1954 ,2091-2112 ,2145-2156 ,2198-2216
Function
Function in SwissProt
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.