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IID00184
 UniprotO14777
ProteinKinetochore protein NDC80 homolog
GeneNDC80
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
642
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 80-286 Hetero dimer : IID00388Complex,IID00393Complex,IID00395Complex
 Evidence X-RAY 2ve7 B Reference
       Region 2ve7 B 80-202 order
       Region 2ve7 B 203-210 disorder
       Region 2ve7 B 211-286 order
Seq 80-286 Hetero dimer : IID00388Complex,IID00393Complex,IID00395Complex
 Evidence X-RAY 2ve7 A Reference
       Region 2ve7 A 80-202 order
       Region 2ve7 A 203-211 disorder
       Region 2ve7 A 212-286 order
Seq 81-196 Monomer :
 Evidence X-RAY 2igp A Reference
       Region 2igp A 81-81 disorder
       Region 2igp A 82-195 order
       Region 2igp A 196-196 disorder
Seqphosphorylation
    44-44 Phosphoserine
    62-62 Phosphoserine
    55-55 Phosphoserine
    165-165 Phosphoserine; by NEK2
    69-69 Phosphoserine
    242-242 Phosphoserine
Seqacetylation
    53-53 N6-acetyllysine
    59-59 N6-acetyllysine
    527-527 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-82,205-217,431-434,444-449,546-549,613-642
Order 83-204,218-430,435-443,450-545,550-612
ProS 205-208,431-434,546-549,613-642
AlphaFold
Disorder 1-79,201-214,216-216,288-292,355-367,369-369,445-445,607-642
Order 80-200,215-215,217-287,293-354,368-368,370-444,446-606
Pfam Hmmer
PF03801 3-220 1.3e-150
SEG 519-544
Function
Function in SwissProt
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).