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IID00188
 UniprotO75362
ProteinZinc finger protein 217
GeneZNF217
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1048
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 469-523 Homo dimer :
 Evidence X-RAY 3uk3 D Reference
       Region 3uk3 D 469-469 disorder
       Region 3uk3 D 470-523 order
 Evidence X-RAY 3uk3 C Reference
       Region 3uk3 C 469-470 disorder
       Region 3uk3 C 471-522 order
       Region 3uk3 C 523-523 disorder
 Evidence X-RAY 4is1 D Reference
       Region 4is1 D 469-469 disorder
       Region 4is1 D 470-523 order
 Evidence X-RAY 4is1 C Reference
       Region 4is1 C 469-470 disorder
       Region 4is1 C 471-522 order
       Region 4is1 C 523-523 disorder
 Evidence X-RAY 4f2j C Reference
       Region 4f2j C 469-470 disorder
       Region 4f2j C 471-522 order
       Region 4f2j C 523-523 disorder
Seq 752-760 Hetero tetramer : Q9Z2F5
 Evidence X-RAY 2hu2 B Reference
       Region 2hu2 B 752-760 order
Seqphosphorylation
    106-106 Phosphoserine
    321-321 Phosphoserine
    322-322 Phosphothreonine
    407-407 Phosphoserine
    593-593 Phosphoserine
    648-648 Phosphothreonine
    662-662 Phosphoserine
    795-795 Phosphoserine
 
Prediction
NeProc
Disorder 242-255,317-358,445-449,607-613,626-702,756-1048
Order 1-241,256-316,359-444,450-606,614-625,703-755
ProS 242-255,317-358,445-449,607-613,626-702,756-773,813-821,851-859,879-915,921-962,980-988,994-1000,1011-1048
AlphaFold
Disorder 1-63,89-126,151-154,180-214,240-295,301-302,304-373,400-469,525-707,737-1048
Order 64-88,127-150,155-179,215-239,296-300,303-303,374-399,470-524,708-736
Pfam Hmmer
PF00096 128-150 2e-05
PF00096 156-178 4.1e-05
PF00096 471-493 0.00022
SEG 116-127 ,437-448
Function
Function in SwissProt
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.