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IID00189
UniprotO75376
ProteinNuclear receptor corepressor 1
GeneNCOR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2440
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 433-486 Monomer :
 Evidence NMR 2eqr A Reference
       Region 2eqr A 433-486 order
       Region 2eqr A 433-438 high_rmsd
       Region 2eqr A 484-486 high_rmsd
Seq 2045-2065 Hetero dimer : IID00033Complex
 Evidence X-RAY 3n00 B Reference
       Region 3n00 B 2045-2065 order
Seq 2045-2065 Hetero tetramer : IID00033Complex
 Evidence X-RAY 3n00 B Reference
       Region 3n00 B 2045-2065 order
Seq 2047-2065 Hetero tetramer : IID00365Complex
 Evidence X-RAY 3kmz D Reference
       Region 3kmz D 2047-2065 order
 Evidence X-RAY 3kmz C Reference
       Region 3kmz C 2047-2065 order
Seq 2258-2276 Hetero trimer : IID00014Complex
 Evidence X-RAY 3h52 M Reference
       Region 3h52 M 2258-2264 disorder
       Region 3h52 M 2265-2274 order
       Region 3h52 M 2275-2276 disorder
 Evidence X-RAY 3h52 N Reference
       Region 3h52 N 2258-2259 disorder
       Region 3h52 N 2260-2274 order
       Region 3h52 N 2275-2276 disorder
Seq 2259-2275 Hetero tetramer : IID00391Complex
 Evidence X-RAY 4wvd C Reference
       Region 4wvd C 2259-2259 disorder
       Region 4wvd C 2260-2275 order
 Evidence X-RAY 4wvd D Reference
       Region 4wvd D 2259-2275 order
Seq 2260-2274 Hetero tetramer : IID00014Complex
 Evidence X-RAY 4mdd D Reference
       Region 4mdd D 2260-2261 disorder
       Region 4mdd D 2262-2273 order
       Region 4mdd D 2274-2274 disorder
 Evidence X-RAY 4mdd C Reference
       Region 4mdd C 2260-2260 disorder
       Region 4mdd C 2261-2273 order
       Region 4mdd C 2274-2274 disorder
SeqProS possible 2045-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. (e.g. IID00050, 74, 82, 83, 103) Hetero dimer : IID00033Complex
       Region 3n00 B 2045-2065 order
SeqProS possible 2045-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. (e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00033Complex
       Region 3n00 B 2045-2065 order
SeqProS possible 2047-2065 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00365Complex
       Region 3kmz C 2047-2065 order
       Region 3kmz D 2047-2065 order
SeqProS possible 2259-2275 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00391Complex
       Region 4wvd C 2260-2275 order
       Region 4wvd D 2259-2275 order
SeqProS possible 2260-2274 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero trimer : IID00014Complex
       Region 3h52 M 2265-2274 order
       Region 3h52 N 2260-2274 order
SeqProS possible 2261-2273 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators.(e.g. IID00050, 74, 82, 83, 103) Hetero tetramer : IID00014Complex
       Region 4mdd C 2261-2273 order
       Region 4mdd D 2262-2273 order
Seqphosphorylation
    2438-2438 Phosphoserine
    2436-2436 Phosphoserine
    2399-2399 Phosphothreonine
    2184-2184 Phosphoserine
    2151-2151 Phosphoserine
    2136-2136 Phosphoserine
    2120-2120 Phosphoserine
    2102-2102 Phosphoserine
    1981-1981 Phosphoserine
    1977-1977 Phosphoserine
    1592-1592 Phosphoserine
    1472-1472 Phosphoserine
    1450-1450 Phosphoserine
    1367-1367 Phosphothreonine
    1322-1322 Phosphoserine
    1263-1263 Phosphoserine
    1281-1281 Phosphoserine
    1249-1249 Phosphoserine
    1196-1196 Phosphoserine
    1111-1111 Phosphoserine
    1195-1195 Phosphoserine
    999-999 Phosphoserine
    224-224 Phosphoserine
    172-172 Phosphoserine
Seqacetylation
    1412-1412 N6-acetyllysine; alternate
    1336-1336 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-177,216-232,329-389,491-506,554-631,684-2440
Order 178-215,233-328,390-490,507-553,632-683
ProS 10-14,26-31,40-46,66-78,85-91,150-157,173-177,329-329,337-343,367-378,383-389,491-494,554-557,614-631,684-694,712-719,895-901,925-928,1160-1169,1184-1188,1247-1250,1676-1680,1930-1937,2048-2063,2145-2148,2263-2267,2360-2374,2418-2440
AlphaFold
Disorder 1-177,216-233,255-255,258-258,260-262,264-266,356-375,377-377,400-428,431-431,434-438,495-626,687-957,974-1612,1615-1721,1724-1821,1823-1824,1826-2440
Order 178-215,234-254,256-257,259-259,263-263,267-355,376-376,378-399,429-430,432-433,439-494,627-686,958-973,1613-1614,1722-1723,1822-1822,1825-1825
Pfam Hmmer
PF00249 437-482 6.6e-11
PF00249 625-670 1.3e-14
SEG 51-73 ,194-231 ,348-365 ,511-553 ,557-568 ,592-626 ,710-731 ,752-768 ,974-982 ,1023-1036 ,1443-1454 ,1707-1734 ,1817-1831 ,1952-1963 ,2019-2035 ,2067-2086
Function
Function in SwissProt
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).