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IID00192
 UniprotO95633
ProteinFollistatin-related protein 3
GeneFSTL3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
263
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-263 Hetero tetramer : IID00338Complex
 Evidence X-RAY 3b4v H Reference
       Region 3b4v H 27-31 disorder
       Region 3b4v H 32-113 order
       Region 3b4v H 114-115 disorder
       Region 3b4v H 116-244 order
       Region 3b4v H 245-263 disorder
 Evidence X-RAY 3b4v G Reference
       Region 3b4v G 27-34 disorder
       Region 3b4v G 35-112 order
       Region 3b4v G 113-116 disorder
       Region 3b4v G 117-244 order
       Region 3b4v G 245-263 disorder
 Evidence X-RAY 3b4v D Reference
       Region 3b4v D 27-31 disorder
       Region 3b4v D 32-244 order
       Region 3b4v D 245-263 disorder
 Evidence X-RAY 3b4v C Reference
       Region 3b4v C 27-34 disorder
       Region 3b4v C 35-112 order
       Region 3b4v C 113-116 disorder
       Region 3b4v C 117-244 order
       Region 3b4v C 245-263 disorder
Seq 36-244 Hetero tetramer : IID50111Complex
 Evidence X-RAY 3sek C Reference
       Region 3sek C 36-41 order
       Region 3sek C 42-45 disorder
       Region 3sek C 46-112 order
       Region 3sek C 113-116 disorder
       Region 3sek C 117-244 order
Seq 97-169 Monomer :
 Evidence NMR 2kcx A Reference
       Region 2kcx A 97-169 order
       Region 2kcx A 127-127 high_rmsd
       Region 2kcx A 169-169 high_rmsd
Seqphosphorylation
    255-255 Phosphoserine; by FAM20C
 
Prediction
NeProc
Disorder 1-7,249-263
Order 8-248
ProS 249-263
AlphaFold
Disorder 1-34,246-263
Order 35-245
Pfam Hmmer
PF00050 121-167 8e-12
PF07648 194-243 3.6e-09
SEG 3-20 ,245-260
Function
Function in SwissProt
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.