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IID00193
 UniprotP11940
ProteinPolyadenylate-binding protein 1
GenePABPC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
636
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-190 Hetero dimer : Q04637
 Evidence X-RAY 4f02 D Reference
       Region 4f02 D 1-9 disorder
       Region 4f02 D 10-183 order
       Region 4f02 D 184-190 disorder
 Evidence X-RAY 4f02 A Reference
       Region 4f02 A 1-9 disorder
       Region 4f02 A 10-184 order
       Region 4f02 A 185-190 disorder
Seq 1-190 Monomer :
 Evidence X-RAY 1cvj H Reference
       Region 1cvj H 1-10 disorder
       Region 1cvj H 11-103 order
       Region 1cvj H 104-112 disorder
       Region 1cvj H 113-132 order
       Region 1cvj H 133-136 disorder
       Region 1cvj H 137-152 order
       Region 1cvj H 153-172 disorder
       Region 1cvj H 173-175 order
       Region 1cvj H 176-190 disorder
 Evidence X-RAY 1cvj G Reference
       Region 1cvj G 1-10 disorder
       Region 1cvj G 11-175 order
       Region 1cvj G 176-190 disorder
 Evidence X-RAY 1cvj F Reference
       Region 1cvj F 1-10 disorder
       Region 1cvj F 11-101 order
       Region 1cvj F 102-111 disorder
       Region 1cvj F 112-132 order
       Region 1cvj F 133-136 disorder
       Region 1cvj F 137-149 order
       Region 1cvj F 150-167 disorder
       Region 1cvj F 168-173 order
       Region 1cvj F 174-190 disorder
 Evidence X-RAY 1cvj E Reference
       Region 1cvj E 1-10 disorder
       Region 1cvj E 11-178 order
       Region 1cvj E 179-190 disorder
 Evidence X-RAY 1cvj D Reference
       Region 1cvj D 1-10 disorder
       Region 1cvj D 11-132 order
       Region 1cvj D 133-136 disorder
       Region 1cvj D 137-175 order
       Region 1cvj D 176-190 disorder
 Evidence X-RAY 1cvj C Reference
       Region 1cvj C 1-10 disorder
       Region 1cvj C 11-178 order
       Region 1cvj C 179-190 disorder
 Evidence X-RAY 1cvj B Reference
       Region 1cvj B 1-10 disorder
       Region 1cvj B 11-132 order
       Region 1cvj B 133-136 disorder
       Region 1cvj B 137-159 order
       Region 1cvj B 160-169 disorder
       Region 1cvj B 170-175 order
       Region 1cvj B 176-190 disorder
 Evidence X-RAY 1cvj A Reference
       Region 1cvj A 1-10 disorder
       Region 1cvj A 11-179 order
       Region 1cvj A 180-190 disorder
Seq 90-199 Monomer :
 Evidence NMR 2k8g A Reference
       Region 2k8g A 90-182 order
       Region 2k8g A 90-94 high_rmsd
       Region 2k8g A 176-182 high_rmsd
 Evidence X-RAY 4f26 A Reference
       Region 4f26 A 99-175 order
       Region 4f26 A 176-199 disorder
 Evidence X-RAY 4f25 A Reference
       Region 4f25 A 99-178 order
       Region 4f25 A 179-199 disorder
Seq 447-458 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgr H Reference
       Region 5lgr H 447-458 order
 Evidence X-RAY 5lgr G Reference
       Region 5lgr G 447-450 disorder
       Region 5lgr G 451-458 order
 Evidence X-RAY 5lgr F Reference
       Region 5lgr F 447-458 order
 Evidence X-RAY 5lgr E Reference
       Region 5lgr E 447-447 disorder
       Region 5lgr E 448-458 order
 Evidence X-RAY 5lgp H Reference
       Region 5lgp H 447-458 order
 Evidence X-RAY 5lgp G Reference
       Region 5lgp G 447-447 disorder
       Region 5lgp G 448-458 order
 Evidence X-RAY 5lgp F Reference
       Region 5lgp F 447-458 order
 Evidence X-RAY 5lgp E Reference
       Region 5lgp E 447-447 disorder
       Region 5lgp E 448-458 order
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dx8 H Reference
       Region 5dx8 H 449-453 disorder
       Region 5dx8 H 454-461 order
       Region 5dx8 H 462-466 disorder
 Evidence X-RAY 5dx8 G Reference
       Region 5dx8 G 449-453 disorder
       Region 5dx8 G 454-460 order
       Region 5dx8 G 461-466 disorder
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dx8 F Reference
       Region 5dx8 F 449-452 disorder
       Region 5dx8 F 453-461 order
       Region 5dx8 F 462-466 disorder
 Evidence X-RAY 5dx8 E Reference
       Region 5dx8 E 449-451 disorder
       Region 5dx8 E 452-460 order
       Region 5dx8 E 461-466 disorder
 Evidence X-RAY 5dx1 I Reference
       Region 5dx1 I 449-451 disorder
       Region 5dx1 I 452-462 order
       Region 5dx1 I 463-466 disorder
 Evidence X-RAY 5dx1 H Reference
       Region 5dx1 H 449-451 disorder
       Region 5dx1 H 452-460 order
       Region 5dx1 H 461-466 disorder
 Evidence X-RAY 5dx1 G Reference
       Region 5dx1 G 449-451 disorder
       Region 5dx1 G 452-461 order
       Region 5dx1 G 462-466 disorder
 Evidence X-RAY 5dx1 F Reference
       Region 5dx1 F 449-451 disorder
       Region 5dx1 F 452-460 order
       Region 5dx1 F 461-466 disorder
Seq 449-466 Hetero tetramer : Q86X55
 Evidence X-RAY 5dxa G Reference
       Region 5dxa G 449-457 disorder
       Region 5dxa G 458-463 order
       Region 5dxa G 464-466 disorder
 Evidence X-RAY 5dxa F Reference
       Region 5dxa F 449-457 disorder
       Region 5dxa F 458-464 order
       Region 5dxa F 465-466 disorder
Seq 449-466 Hetero trimer : Q86X55
 Evidence X-RAY 5dxa I Reference
       Region 5dxa I 449-457 disorder
       Region 5dxa I 458-464 order
       Region 5dxa I 465-466 disorder
Seq 456-464 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgs H Reference
       Region 5lgs H 456-456 disorder
       Region 5lgs H 457-464 order
 Evidence X-RAY 5lgs G Reference
       Region 5lgs G 456-456 disorder
       Region 5lgs G 457-464 order
 Evidence X-RAY 5lgs F Reference
       Region 5lgs F 456-464 order
 Evidence X-RAY 5lgs E Reference
       Region 5lgs E 456-456 disorder
       Region 5lgs E 457-464 order
Seq 456-466 Hetero octamer : Q9WVG6
 Evidence X-RAY 5lgq H Reference
       Region 5lgq H 456-464 order
       Region 5lgq H 465-466 disorder
 Evidence X-RAY 5lgq G Reference
       Region 5lgq G 456-456 disorder
       Region 5lgq G 457-464 order
       Region 5lgq G 465-466 disorder
 Evidence X-RAY 5lgq F Reference
       Region 5lgq F 456-456 disorder
       Region 5lgq F 457-464 order
       Region 5lgq F 465-466 disorder
 Evidence X-RAY 5lgq E Reference
       Region 5lgq E 456-456 disorder
       Region 5lgq E 457-464 order
       Region 5lgq E 465-466 disorder
Seq 498-636 Monomer :
 Evidence NMR 1g9l A Reference
       Region 1g9l A 498-636 order
       Region 1g9l A 498-542 high_rmsd
       Region 1g9l A 623-636 high_rmsd
Seq 541-623 Hetero dimer : Q8R050
 Evidence NMR 2rqh B Reference
       Region 2rqh B 541-623 order
       Region 2rqh B 541-541 high_rmsd
       Region 2rqh B 619-623 high_rmsd
Seq 541-623 Hetero dimer : Q8R050
 Evidence NMR 2rqg B Reference
       Region 2rqg B 541-623 order
       Region 2rqg B 541-542 high_rmsd
       Region 2rqg B 622-623 high_rmsd
Seq 543-621 Hetero dimer : Q92615
 Evidence X-RAY 3pth A Reference
       Region 3pth A 543-543 disorder
       Region 3pth A 544-618 order
       Region 3pth A 619-621 disorder
Seq 544-617 Monomer :
 Evidence X-RAY 3kur H Reference
       Region 3kur H 544-616 order
       Region 3kur H 617-617 disorder
 Evidence X-RAY 3kur G Reference
       Region 3kur G 544-615 order
       Region 3kur G 616-617 disorder
 Evidence X-RAY 3kur F Reference
       Region 3kur F 544-615 order
       Region 3kur F 616-617 disorder
 Evidence X-RAY 3kur E Reference
       Region 3kur E 544-615 order
       Region 3kur E 616-617 disorder
 Evidence X-RAY 3kur D Reference
       Region 3kur D 544-544 disorder
       Region 3kur D 545-615 order
       Region 3kur D 616-617 disorder
 Evidence X-RAY 3kur C Reference
       Region 3kur C 544-615 order
       Region 3kur C 616-617 disorder
 Evidence X-RAY 3kur B Reference
       Region 3kur B 544-616 order
       Region 3kur B 617-617 disorder
 Evidence X-RAY 3kur A Reference
       Region 3kur A 544-616 order
       Region 3kur A 617-617 disorder
Seq 544-626 Hetero dimer : IID00571Complex
 Evidence X-RAY 3pkn A Reference
       Region 3pkn A 544-622 order
       Region 3pkn A 623-626 disorder
Seq 544-626 Hetero dimer : IID00580Complex
 Evidence X-RAY 3ktr A Reference
       Region 3ktr A 544-623 order
       Region 3ktr A 624-626 disorder
Seq 544-626 Hetero dimer : IID00587Complex
 Evidence X-RAY 2x04 A Reference
       Region 2x04 A 545-616 order
       Region 2x04 A 617-619 disorder
 Evidence X-RAY 2x04 B Reference
       Region 2x04 B 545-618 order
       Region 2x04 B 619-619 disorder
 Evidence X-RAY 3ktp A Reference
       Region 3ktp A 544-621 order
       Region 3ktp A 622-626 disorder
Seq 544-626 Hetero dimer : P15170
 Evidence X-RAY 3kui A Reference
       Region 3kui A 544-544 disorder
       Region 3kui A 545-625 order
       Region 3kui A 626-626 disorder
Seq 544-626 Hetero dimer : IID00573Complex
 Evidence X-RAY 3kuj A Reference
       Region 3kuj A 544-620 order
       Region 3kuj A 621-626 disorder
Seq 544-636 Hetero dimer : IID00582Complex
 Evidence NMR 1jgn A Reference
       Region 1jgn A 544-636 order
       Region 1jgn A 544-544 high_rmsd
       Region 1jgn A 624-636 high_rmsd
 Evidence X-RAY 3kut B Reference
       Region 3kut B 544-544 disorder
       Region 3kut B 545-623 order
       Region 3kut B 624-626 disorder
 Evidence X-RAY 3kut A Reference
       Region 3kut A 544-626 order
 Evidence X-RAY 3kus B Reference
       Region 3kus B 544-552 disorder
       Region 3kus B 553-622 order
       Region 3kus B 623-626 disorder
 Evidence X-RAY 3kus A Reference
       Region 3kus A 544-544 disorder
       Region 3kus A 545-626 order
Seq 544-636 Hetero dimer : IID00586Complex
 Evidence NMR 1jh4 A Reference
       Region 1jh4 A 544-636 order
       Region 1jh4 A 620-636 high_rmsd
SeqProS predicted 454-461 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dx8 G 454-460 order
       Region 5dx8 H 454-461 order
SeqProS predicted 454-461 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dx8 E 452-460 order
       Region 5dx8 F 453-461 order
       Region 5dx1 F 452-460 order
       Region 5dx1 G 452-461 order
       Region 5dx1 H 452-460 order
       Region 5dx1 I 452-462 order
SeqProS predicted 458-464 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero tetramer : Q86X55
       Region 5dxa F 458-464 order
       Region 5dxa G 458-463 order
SeqProS predicted 458-464 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero trimer : Q86X55
       Region 5dxa I 458-464 order
Seqphosphorylation
    315-315 Phosphoserine
    319-319 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    512-512 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-7,377-560,618-636
Order 8-376,561-617
ProS 1-7,377-387,407-411,420-424,435-440,548-560,630-636
AlphaFold
Disorder 1-10,187-187,387-548,628-636
Order 11-186,188-386,549-627
Pfam Hmmer
PF00076 13-84 1.1e-27
PF00076 101-170 1.7e-25
PF00076 193-263 3.4e-31
PF00076 296-365 1.3e-22
PF00658 543-614 6.5e-48
SEG 455-462 ,492-509 ,615-626
Function
Function in SwissProt
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299).
(Microbial infection) Positively regulates the replication of dengue virus (DENV).