Search Keyword:


Search option:


IID00198
 UniprotP30307
ProteinM-phase inducer phosphatase 3
GeneCDC25C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
473
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 126-134 Hetero dimer : IID00200Complex
 Evidence X-RAY 2ojx E Reference
       Region 2ojx E 126-132 order
       Region 2ojx E 133-134 disorder
 Evidence X-RAY 3bzi E Reference
       Region 3bzi E 126-132 order
       Region 3bzi E 133-134 disorder
Seq 207-220 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5m35 D Reference
       Region 5m35 D 207-212 order
       Region 5m35 D 213-219 order
 Evidence X-RAY 5m35 C Reference
       Region 5m35 C 207-210 order
       Region 5m35 C 211-220 order
Seq 207-226 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5m37 D Reference
       Region 5m37 D 207-223 order
       Region 5m37 D 224-226 disorder
 Evidence X-RAY 5m37 C Reference
       Region 5m37 C 207-207 disorder
       Region 5m37 C 208-224 order
       Region 5m37 C 225-226 disorder
Seq 207-244 Hetero trimer : IID00061Complex
 Evidence X-RAY 5m36 D Reference
       Region 5m36 D 207-211 disorder
       Region 5m36 D 212-220 order
       Region 5m36 D 221-244 disorder
 Evidence X-RAY 5m36 C Reference
       Region 5m36 C 207-225 order
       Region 5m36 C 226-244 disorder
Seq 270-462 Homo dimer :
 Evidence X-RAY 3op3 A Reference
       Region 3op3 A 270-279 disorder
       Region 3op3 A 280-379 order
       Region 3op3 A 380-381 disorder
       Region 3op3 A 382-448 order
       Region 3op3 A 449-462 disorder
Seqphosphorylation
    61-61 Phosphoserine
    64-64 Phosphoserine
    130-130 Phosphothreonine
    122-122 Phosphoserine; by CDK1
    67-67 Phosphothreonine
    129-129 Phosphoserine
    48-48 Phosphothreonine
    57-57 Phosphoserine
    38-38 Phosphoserine
    20-20 Phosphoserine
    61-61 Phosphoserine
    168-168 Phosphoserine
    61-61 Phosphoserine
    472-472 Phosphoserine
    216-216 Phosphoserine; by CHEK1
    214-214 Phosphoserine; by CDK1
    198-198 Phosphoserine; by PLK3
    191-191 Phosphoserine; by PLK3
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-282,450-473
Order 283-449
ProS 14-44,50-80,97-101,129-138,209-214,260-265,279-282,450-473
AlphaFold
Disorder 1-280,472-473
Order 281-471
Pfam Hmmer
PF06617 93-272 1.9e-82
PF00581 314-422 1.1e-35
SEG 6-23
Function
Function in SwissProt
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.