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IID00203
 UniprotP78504
ProteinProtein jagged-1
GeneJAG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1218
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 32-335 Monomer :
 Evidence X-RAY 4cc1 B Reference
       Region 4cc1 B 32-335 order
 Evidence X-RAY 4cc1 A Reference
       Region 4cc1 A 32-335 order
 Evidence X-RAY 4cc0 B Reference
       Region 4cc0 B 32-298 order
       Region 4cc0 B 299-335 disorder
 Evidence X-RAY 4cc0 A Reference
       Region 4cc0 A 32-335 order
Seq 32-335 Homo dimer :
 Evidence X-RAY 4cbz B Reference
       Region 4cbz B 32-55 order
       Region 4cbz B 56-65 disorder
       Region 4cbz B 66-142 order
       Region 4cbz B 143-147 disorder
       Region 4cbz B 148-298 order
       Region 4cbz B 299-335 disorder
 Evidence X-RAY 4cbz A Reference
       Region 4cbz A 32-55 order
       Region 4cbz A 56-65 disorder
       Region 4cbz A 66-142 order
       Region 4cbz A 143-147 disorder
       Region 4cbz A 148-335 order
Seq 185-335 Monomer :
 Evidence X-RAY 2vj2 B Reference
       Region 2vj2 B 185-185 disorder
       Region 2vj2 B 186-335 order
 Evidence X-RAY 2vj2 A Reference
       Region 2vj2 A 185-186 disorder
       Region 2vj2 A 187-335 order
Seq 186-335 Hetero trimer :
 Evidence X-RAY 5bo1 A Reference
       Region 5bo1 A 186-335 order
Seq 186-335 Hetero trimer :
 Evidence X-RAY 5bo1 B Reference
       Region 5bo1 B 186-335 order
Seq 252-295 Monomer :
 Evidence NMR 2kb9 A Reference
       Region 2kb9 A 252-295 order
       Region 2kb9 A 252-252 high_rmsd
Seqdisorder 1094-1218
 Evidence NMR Reference
       Region 1094-1218 disorder
Seqdisorder 1094-1218
 Evidence CD Reference
       Region 1094-1218 disorder
Seq 1120-1130 Hetero dimer : Q86YT6
 Evidence X-RAY 4xi7 C Reference
       Region 4xi7 C 1120-1120 disorder
       Region 4xi7 C 1121-1126 order
       Region 4xi7 C 1127-1130 disorder
SeqProS verified 1121-1126 Hetero dimer : Q86YT6
       Region 4xi7 C 1121-1126 order
       Region 1094-1218 disorder
 
Prediction
NeProc
Disorder 1-24,1056-1068,1092-1195
Order 25-1055,1069-1091,1196-1218
ProS 7-24,1056-1059,1066-1068,1092-1100,1108-1141,1149-1195
AlphaFold
Disorder 1-31,67-68,114-114,144-147,327-327,336-339,341-342,353-357,375-375,379-381,384-386,393-394,401-401,403-415,430-433,516-516,524-527,543-545,563-576,580-597,610-612,698-698,706-712,722-726,733-735,737-737,742-751,761-765,773-773,788-788,802-802,848-851,857-862,865-868,872-872,905-909,939-956,1020-1025,1041-1046,1058-1070,1092-1092,1094-1218
Order 32-66,69-113,115-143,148-326,328-335,340-340,343-352,358-374,376-378,382-383,387-392,395-400,402-402,416-429,434-515,517-523,528-542,546-562,577-579,598-609,613-697,699-705,713-721,727-732,736-736,738-741,752-760,766-772,774-787,789-801,803-847,852-856,863-864,869-871,873-904,910-938,957-1019,1026-1040,1047-1057,1071-1091,1093-1093
Pfam Hmmer
PF07657 31-110 1.8e-50
PF01414 167-229 8.9e-42
PF00008 300-333 3.4e-08
PF00008 340-371 6.8e-10
PF00008 378-409 5.7e-11
PF00008 454-484 2.3e-08
PF00008 491-522 4e-09
PF00008 529-560 1e-08
PF00008 633-664 5.8e-10
PF00008 671-702 2.1e-11
PF00008 709-740 0.00032
PF00008 748-779 1.2e-10
PF00008 786-817 2.5e-08
PF00008 824-855 1.1e-06
SEG 2-26
Function
Function in SwissProt
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).