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IID00204
 UniprotP84103
ProteinSerine/arginine-rich splicing factor 3
GeneSRSF3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
164
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-86 Monomer : P19909
 Evidence NMR 2i2y A Reference
       Region 2i2y A 1-86 order
Seq 1-86 Monomer : P19909
 Evidence NMR 2i38 A Reference
       Region 2i38 A 1-86 order
Seqphosphorylation
    5-5 Phosphoserine
Seqacetylation
    23-23 N6-acetyllysine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-5,86-164
Order 6-85
ProS 1-5,95-123,155-164
AlphaFold
Disorder 1-9,18-21,44-44,46-46,71-74,81-164
Order 10-17,22-43,45-45,47-70,75-80
Pfam Hmmer
PF00076 12-78 4.1e-23
SEG 86-143 ,148-160
Function
Function in SwissProt
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).