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IID00205
UniprotQ01081
ProteinSplicing factor U2AF 35 kDa subunit
GeneU2AF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
240
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 43-146 Hetero dimer : IID00147Complex
 Evidence X-RAY 1jmt A Reference
       Region 1jmt A 43-56 order
       Region 1jmt A 57-62 disorder
       Region 1jmt A 63-146 order
Seqphosphorylation
    145-145 Phosphoserine
    61-61 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 182-240
Order 1-181
ProS 182-189,227-240
AlphaFold
Disorder 1-1,10-10,58-68,188-240
Order 2-9,11-57,69-187
Pfam Hmmer
PF00642 13-39 4.2e-07
PF00642 149-175 0.00068
SEG 80-98 ,179-239
Function
Function in SwissProt
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.