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IID00208
 UniprotQ04724
ProteinTransducin-like enhancer protein 1
GeneTLE1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
770
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-156 Homo tetramer :
 Evidence X-RAY 4om3 D Reference
       Region 4om3 D 15-19 disorder
       Region 4om3 D 20-133 order
       Region 4om3 D 134-134 disorder
       Region 4om3 D 135-142 order
       Region 4om3 D 143-156 disorder
 Evidence X-RAY 4om3 C Reference
       Region 4om3 C 15-18 disorder
       Region 4om3 C 19-135 order
       Region 4om3 C 136-156 disorder
 Evidence X-RAY 4om3 B Reference
       Region 4om3 B 15-19 disorder
       Region 4om3 B 20-131 order
       Region 4om3 B 132-156 disorder
 Evidence X-RAY 4om3 A Reference
       Region 4om3 A 15-18 disorder
       Region 4om3 A 19-135 order
       Region 4om3 A 136-156 disorder
 Evidence X-RAY 4om2 D Reference
       Region 4om2 D 1-20 disorder
       Region 4om2 D 21-128 order
       Region 4om2 D 129-156 disorder
 Evidence X-RAY 4om2 C Reference
       Region 4om2 C 1-20 disorder
       Region 4om2 C 21-130 order
       Region 4om2 C 131-156 disorder
 Evidence X-RAY 4om2 B Reference
       Region 4om2 B 1-21 disorder
       Region 4om2 B 22-128 order
       Region 4om2 B 129-156 disorder
 Evidence X-RAY 4om2 A Reference
       Region 4om2 A 1-19 disorder
       Region 4om2 A 20-131 order
       Region 4om2 A 132-156 disorder
Seq 443-770 Hetero trimer :
 Evidence X-RAY 2ce9 A This region binds to a peptide. Reference
       Region 2ce9 A 443-770 order
 Evidence X-RAY 2ce9 B This region binds to a peptide. Reference
       Region 2ce9 B 443-770 order
Seq 443-770 Hetero trimer :
 Evidence X-RAY 2ce8 C This region binds to a peptide. Reference
       Region 2ce8 C 443-770 order
 Evidence X-RAY 2ce8 D This region binds to a peptide. Reference
       Region 2ce8 D 443-770 order
Seq 443-770 Hetero trimer :
 Evidence X-RAY 2ce9 C This region binds to a peptide. Reference
       Region 2ce9 C 443-770 order
 Evidence X-RAY 2ce9 D This region binds to a peptide. Reference
       Region 2ce9 D 443-450 order
       Region 2ce9 D 451-455 disorder
       Region 2ce9 D 456-770 order
Seq 443-770 Homo dimer :
 Evidence X-RAY 5mwj B Reference
       Region 5mwj B 443-450 order
       Region 5mwj B 451-455 disorder
       Region 5mwj B 456-513 order
       Region 5mwj B 514-517 disorder
       Region 5mwj B 518-559 order
       Region 5mwj B 560-562 disorder
       Region 5mwj B 563-625 order
       Region 5mwj B 626-627 disorder
       Region 5mwj B 628-770 order
 Evidence X-RAY 5mwj A Reference
       Region 5mwj A 443-451 order
       Region 5mwj A 452-454 disorder
       Region 5mwj A 455-513 order
       Region 5mwj A 514-518 disorder
       Region 5mwj A 519-559 order
       Region 5mwj A 560-563 disorder
       Region 5mwj A 564-770 order
 Evidence X-RAY 1gxr B Reference
       Region 1gxr B 443-450 order
       Region 1gxr B 451-455 disorder
       Region 1gxr B 456-514 order
       Region 1gxr B 515-517 disorder
       Region 1gxr B 518-560 order
       Region 1gxr B 561-563 disorder
       Region 1gxr B 564-685 order
       Region 1gxr B 686-687 disorder
       Region 1gxr B 688-770 order
 Evidence X-RAY 1gxr A Reference
       Region 1gxr A 443-561 order
       Region 1gxr A 562-563 disorder
       Region 1gxr A 564-770 order
Seq 443-770 Hetero trimer :
 Evidence X-RAY 2ce8 A This region binds to a peptide. Reference
       Region 2ce8 A 443-770 order
 Evidence X-RAY 2ce8 B This region binds to a peptide. Reference
       Region 2ce8 B 443-770 order
Seqphosphorylation
    239-239 Phosphoserine
    259-259 Phosphoserine; by CDK1
    263-263 Phosphoserine; by CDK1
    267-267 Phosphoserine; by CDK1
    286-286 Phosphoserine
 
Prediction
NeProc
Disorder 1-17,102-443
Order 18-101,444-770
ProS 1-6,111-128,185-207,225-253,267-275,303-307,338-351,357-360,370-378,400-407,416-430,440-443
AlphaFold
Disorder 1-21,126-442
Order 22-125,443-770
Pfam Hmmer
PF03920 1-136 1.5e-95
PF00400 564-602 2.6e-05
PF00400 606-644 1.5e-08
SEG 98-114 ,145-178 ,180-195 ,257-269 ,283-298 ,403-412
Function
Function in SwissProt
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.