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IID00209
 UniprotQ05086
ProteinUbiquitin-protein ligase E3A
GeneUBE3A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
875
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 24-87 Monomer :
 Evidence NMR 2kr1 A Reference
       Region 2kr1 A 24-87 order
       Region 2kr1 A 24-25 high_rmsd
       Region 2kr1 A 86-87 high_rmsd
Seqdisorder 401-418
 Evidence CD Reference
       Region 401-418 disorder
Seq 401-418 Monomer :
 Evidence NMR 1eqx A Reference
       Region 1eqx A 401-418 order
       Region 1eqx A 401-401 high_rmsd
Seq 406-414 Hetero hexamer : IID90005Complex,IID90020Complex
 Evidence X-RAY 4giz B Reference
       Region 4giz B 406-414 order
 Evidence X-RAY 4giz A Reference
       Region 4giz A 406-414 order
Seq 406-417 Hetero octamer : IID00015Complex,IID90005Complex,IID90020Complex
 Evidence X-RAY 4xr8 B Reference
       Region 4xr8 B 406-416 order
       Region 4xr8 B 417-417 disorder
 Evidence X-RAY 4xr8 A Reference
       Region 4xr8 A 406-417 order
Seq 518-875 Hetero tetramer : IID00592Complex
 Evidence X-RAY 1c4z C Reference
       Region 1c4z C 518-519 disorder
       Region 1c4z C 520-869 order
       Region 1c4z C 870-875 disorder
 Evidence X-RAY 1c4z B Reference
       Region 1c4z B 518-519 disorder
       Region 1c4z B 520-869 order
       Region 1c4z B 870-875 disorder
 Evidence X-RAY 1c4z A Reference
       Region 1c4z A 518-519 disorder
       Region 1c4z A 520-869 order
       Region 1c4z A 870-875 disorder
Seq 518-875 Homo trimer :
 Evidence X-RAY 1d5f C Reference
       Region 1d5f C 518-519 disorder
       Region 1d5f C 520-869 order
       Region 1d5f C 870-875 disorder
 Evidence X-RAY 1d5f B Reference
       Region 1d5f B 518-519 disorder
       Region 1d5f B 520-869 order
       Region 1d5f B 870-875 disorder
 Evidence X-RAY 1d5f A Reference
       Region 1d5f A 518-519 disorder
       Region 1d5f A 520-869 order
       Region 1d5f A 870-875 disorder
SeqProS verified 403-416 Hetero octamer : IID00015Complex,IID90005Complex,IID90020Complex
       Region 4giz B 406-414 order
       Region 4xr8 A 406-417 order
       Region 4xr8 B 406-416 order
       Region 401-418 disorder
SeqProS verified 403-416 Hetero hexamer : IID90005Complex,IID90020Complex
       Region 4giz A 406-414 order
       Region 401-418 disorder
Seqphosphorylation
    659-659 Phosphotyrosine; by ABL1
    218-218 Phosphoserine
 
Prediction
NeProc
Disorder 1-27,88-123,185-221
Order 28-87,124-184,222-385,391-875
ProS 1-9,88-109,194-209
AlphaFold
Disorder 1-24,27-27,85-121,171-231,392-392,396-423,470-472,563-568,687-687,870-875
Order 25-26,28-84,122-170,232-391,393-395,424-469,473-562,569-686,688-869
Pfam Hmmer
PF00632 576-875 1e-161
SEG 183-212 ,394-406 ,855-864
Function
Function in SwissProt
(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.