Search Keyword:


Search option:


IID00211
 UniprotQ14469
ProteinTranscription factor HES-1
GeneHES1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
280
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-95 Homo dimer :
 Evidence NMR 2mh3 A Reference
       Region 2mh3 A 27-95 order
       Region 2mh3 A 27-37 high_rmsd
 Evidence NMR 2mh3 B Reference
       Region 2mh3 B 27-95 order
       Region 2mh3 B 27-37 high_rmsd
Seqdisorder 155-280
 Evidence CD Reference
       Region 155-280 disorder
 
Prediction
NeProc
Disorder 1-52,149-280
Order 53-92,99-148
ProS 1-7,34-52,215-224,272-280
AlphaFold
Disorder 1-37,99-103,153-166,172-182,186-217,234-277,279-280
Order 38-98,104-152,167-171,183-185,218-233,278-278
Pfam Hmmer
PF00010 35-92 5.3e-18
PF07527 108-152 8.4e-21
SEG 10-21 ,156-202
Function
Function in SwissProt
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.