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IID00212
 UniprotQ15599
ProteinNa(+)/H(+) exchange regulatory cofactor NHE-RF2
GeneSLC9A3R2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
337
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 9-90 Monomer : Q9HBW0
 Evidence X-RAY 4p0c A Reference
       Region 4p0c A 9-90 order
Seq 9-91 Monomer :
 Evidence X-RAY 2ocs A Reference
       Region 2ocs A 9-28 order
       Region 2ocs A 29-31 disorder
       Region 2ocs A 32-91 order
Seq 147-228 Monomer :
 Evidence X-RAY 2he4 A Reference
       Region 2he4 A 147-228 order
Seq 310-337 Hetero dimer : IID50114Complex
 Evidence X-RAY 2d11 H Reference
       Region 2d11 H 310-320 disorder
       Region 2d11 H 321-337 order
 Evidence X-RAY 2d11 G Reference
       Region 2d11 G 310-320 disorder
       Region 2d11 G 321-337 order
 Evidence X-RAY 2d11 F Reference
       Region 2d11 F 310-319 disorder
       Region 2d11 F 320-337 order
 Evidence X-RAY 2d11 E Reference
       Region 2d11 E 310-319 disorder
       Region 2d11 E 320-337 order
SeqProS possible 320-337 This region is described to be disordered in the free state. (PubMed=16615918) Hetero dimer : IID50114Complex
       Region 2d11 E 320-337 order
       Region 2d11 F 320-337 order
       Region 2d11 G 321-337 order
       Region 2d11 H 321-337 order
Seqphosphorylation
    303-303 Phosphoserine
    280-280 Phosphoserine
    269-269 Phosphoserine
    254-254 Phosphoserine
    183-183 Phosphoserine
    130-130 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,104-141,247-337
Order 6-103,142-246
ProS 104-141,247-257,298-337
AlphaFold
Disorder 1-7,29-31,99-146,246-337
Order 8-28,32-98,147-245
Pfam Hmmer
PF00595 11-88 4.7e-15
PF00595 151-228 1.1e-15
SEG 57-67 ,306-317
Function
Function in SwissProt
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.