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IID00214
 UniprotQ16629
ProteinSerine/arginine-rich splicing factor 7
GeneSRSF7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
238
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 12-98 Monomer :
 Evidence NMR 2hvz A Reference
       Region 2hvz A 12-98 order
       Region 2hvz A 88-92 high_rmsd
Seqphosphorylation
    233-233 Phosphoserine
    231-231 Phosphoserine
    196-196 Phosphoserine
    194-194 Phosphoserine
    192-192 Phosphoserine
    183-183 Phosphoserine
    181-181 Phosphoserine
    167-167 Phosphoserine
    165-165 Phosphoserine
    163-163 Phosphoserine
    32-32 Phosphoserine
Seqacetylation
    24-24 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-8,86-238
Order 9-85
ProS 1-8,86-86,100-122,235-238
AlphaFold
Disorder 1-10,19-22,45-47,73-73,82-103,108-108,117-118,121-233,235-238
Order 11-18,23-44,48-72,74-81,104-107,109-116,119-120,234-234
Pfam Hmmer
PF00076 13-79 9.9e-22
PF00098 104-121 0.00026
SEG 86-105 ,120-188 ,192-234
Function
Function in SwissProt
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.