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IID00216
 UniprotQ6VMQ6
ProteinActivating transcription factor 7-interacting protein 1
GeneATF7IP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1270
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 938-981 Hetero dimer : IID00376Complex
 Evidence NMR 2rpq B Reference
       Region 2rpq B 938-964 disorder
       Region 2rpq B 965-975 order
       Region 2rpq B 976-981 disorder
SeqProS possible 965-975 SUMO binding motif Hetero dimer : IID00376Complex
       Region 2rpq B 965-975 order
Seqphosphorylation
    899-899 Phosphoserine
    673-673 Phosphoserine
    559-559 Phosphoserine
    496-496 Phosphoserine
    479-479 Phosphoserine
    477-477 Phosphoserine
    474-474 Phosphoserine
    473-473 Phosphoserine
    445-445 Phosphoserine
    118-118 Phosphothreonine
    113-113 Phosphoserine
    57-57 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-9,23-547,576-610,617-621,629-631,667-1167,1266-1270
Order 10-22,548-575,611-616,622-628,632-666,1168-1205,1211-1265
ProS 23-53,62-77,153-158,300-304,437-441,483-506,529-532,580-587,596-610,617-621,629-631,667-667,1150-1167
AlphaFold
Disorder 1-11,39-588,663-1138,1206-1207,1265-1270
Order 12-38,589-662,1139-1205,1208-1264
SEG 132-145 ,150-183 ,187-203 ,209-222 ,248-270 ,532-543 ,569-580 ,754-768 ,839-854 ,1002-1014 ,1068-1075
Function
Function in SwissProt
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).