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IID00217
 UniprotQ7RTN6
ProteinSTE20-related kinase adapter protein alpha
GeneSTRADA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
431
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 59-431 Hetero dimer : Q9Y376
 Evidence X-RAY 3gni B Reference
       Region 3gni B 59-59 disorder
       Region 3gni B 60-291 order
       Region 3gni B 292-347 disorder
       Region 3gni B 348-382 order
       Region 3gni B 383-385 disorder
       Region 3gni B 386-401 order
       Region 3gni B 402-424 disorder
       Region 3gni B 425-431 order
Seq 59-431 Hetero trimer : IID00613Complex,Q9Y376
 Evidence X-RAY 2wtk B Reference
       Region 2wtk B 59-60 disorder
       Region 2wtk B 61-279 order
       Region 2wtk B 280-280 disorder
       Region 2wtk B 281-292 order
       Region 2wtk B 293-295 disorder
       Region 2wtk B 296-299 order
       Region 2wtk B 300-347 disorder
       Region 2wtk B 348-419 order
       Region 2wtk B 420-427 disorder
       Region 2wtk B 428-431 order
 Evidence X-RAY 2wtk E Reference
       Region 2wtk E 59-59 disorder
       Region 2wtk E 60-64 order
       Region 2wtk E 65-67 disorder
       Region 2wtk E 68-279 order
       Region 2wtk E 280-280 disorder
       Region 2wtk E 281-292 order
       Region 2wtk E 293-294 disorder
       Region 2wtk E 295-298 order
       Region 2wtk E 299-347 disorder
       Region 2wtk E 348-418 order
       Region 2wtk E 419-427 disorder
       Region 2wtk E 428-431 order
Seq 420-431 Hetero dimer : Q9Y376
 Evidence X-RAY 1upk B Reference
       Region 1upk B 420-427 disorder
       Region 1upk B 428-431 order
Seqphosphorylation
    2-2 Phosphoserine
    46-46 Phosphoserine
    329-329 Phosphothreonine; by LKB1
    419-419 Phosphothreonine; by LKB1
 
Prediction
NeProc
Disorder 1-9,19-60,309-340,406-431
Order 10-18,61-308,341-405
ProS 1-9,19-31,319-324,406-412,417-431
AlphaFold
Disorder 1-3,18-60,310-343,402-431
Order 4-17,61-309,344-401
Pfam Hmmer
PF00069 69-379 5.1e-24
Function
Function in SwissProt
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Biological Process
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
STK11/CAB39/STRADAStructure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex