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IID00218
UniprotQ86VN1
ProteinVacuolar protein-sorting-associated protein 36
GeneVPS36
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
386
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-138 Hetero dimer : P0CG48
 Evidence X-RAY 2hth B Reference
       Region 2hth B 1-2 disorder
       Region 2hth B 3-131 order
       Region 2hth B 132-138 disorder
Seq 149-386 Hetero tetramer : Q96H20,Q9BRG1
 Evidence X-RAY 2zme B Reference
       Region 2zme B 149-171 disorder
       Region 2zme B 172-386 order
Seq 169-386 Hetero trimer : Q96H20,Q9BRG1
 Evidence X-RAY 3cuq B Reference
       Region 3cuq B 169-171 disorder
       Region 3cuq B 172-201 order
       Region 3cuq B 202-211 disorder
       Region 3cuq B 212-385 order
       Region 3cuq B 386-386 disorder
 
Prediction
NeProc
Disorder 85-91,139-150,200-222
Order 1-84,92-134,151-199,223-386
ProS 215-222
AlphaFold
Disorder 134-160,196-196,199-200,202-239,386-386
Order 1-133,161-195,197-198,201-201,240-385
Pfam Hmmer
PF04132 126-384 7.2e-186
SEG 351-362
Function
Function in SwissProt
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.